Tecnologias de biotecnologia para venda ou licença

22.12.2011 22:00

A seguir, são tecnologias Biotech oferecidos para venda ou licença. Vendo tecnologias para a venda é um serviço gratuito de IdeaConnection.com, como está se conectando com o vendedor se uma tecnologia lhe interessa. Clique em um título abaixo para mais informações. Biotecnologia inclui avanços na biologia, agricultura, ciência dos alimentos, engenharia genética, hibridação e bioengenharia. Sua lista de biotecnologia para a venda ou licença aqui.

Lacritin-syndecan proteínas de fusão

A presente invenção refere-se a métodos e composições úteis para a regulação da lacritin, syndecan e lacritin-syndecan interações ea jusante da via de sinalização lacritin-syndecan ..

Hidrogenase polipeptídeo E MÉTODOS DE USO

Contidas neste documento são polipeptídeos tendo atividade hidrogenase. O polipeptídeo pode ser multimérica, e pode ter uma atividade hidrogenase de pelo menos 0,05 micromoles H2 produzido min-1 mg de proteína-1. Também prov ..

CAS6 polipeptídeos e métodos de uso

Fornecidos aqui métodos para clivar um alvo polinucleotídeo RNA. O alvo polinucleotídeo RNA inclui um domínio de reconhecimento Cas6 e um sítio de clivagem, e pode ser baseado em uma repetição de um l. CRISPR.

Biotina-transporte facilitado em bactérias gram-negativas

Biotinilação de compostos, tais como peptídeos e peptidomimetics facilita o transporte ilícito de compostos em bactérias Gram negativas.

Progenitores neuronais da cultura de alimentação livre de células estaminais embrionárias humanas

A presente invenção refere-se a métodos para a produção livre de células alimentador de células neuroprogenitor (de preferência aderente) a partir de células-tronco embrionárias, de preferência células estaminais embrionárias humanas, o alimentador de células-f ..

REVERSE fragmentos de restrição ENSAIO polimorfismo de comprimento E USOS DOS MESMOS

A presente invenção apresenta um reverso Fragmento de Restrição Polimorfismo método Length (RRFLP) para a detecção da presença de um site informativo enzima de restrição em uma seqüência de nucleotídeos. T..

Valorização do toxicidades Bacillus Thuringiensis Cry para Lesser Minhocanders Alphitobius diaperinus

A presente invenção está relacionada em parte à descoberta de que BtBooster (BTB) peptídeos aumentar a tensão Bt Cry e toxicidade da proteína para o inseto. A presente invenção também está relacionada em parte para po ..

SISTEMA RNAi-LIKE procarióticas e métodos de uso

Fornecidos aqui métodos para inativação de um polinucleotídeo alvo. Os métodos de usar um psiRNA tendo uma região 5 'e uma região 3'. A região 5 'inclui, mas não limitado a, 5-10 nucleotídeos ch ..

PYRIDINONE HYDROXYCYCLOPENTYL CARBOXAMIDES: inibidores da integrase do HIV com objetivos terapêuticos

Quiral e aquiral nova oxi-substituído diketocarboxamides ciclopentil pyridinone e seus derivados e métodos para sua preparação são divulgados. Os compostos incluem tautômeros, regioisômeros ..

VETORES compreendendo um PROMOTOR MAGNUM ESPECÍFICAS PARA transgênese AVIÁRIA

Esta invenção fornece vetores e métodos para a introdução estável de seqüências de ácido nucléico exógeno no genoma de um pássaro e disse para expressar sequências exógenas para alterar o fenótipo ..

Vacina recombinante paramixovírus AVIÁRIA E MÉTODO PARA FAZER E USAR MESMO

A presente invenção engloba composições engenharia APMV ou vacinas. A vacina ou composição pode ser uma composição APMV recombinante ou vacina. A presente invenção compreende métodos para a m..

PEPTÍDEOS modificado com toxina melhoramento dos efeitos.

Esta invenção refere-se, em parte, para modificar BtBooster (BTB) peptídeos, em parte para aumentar a sua estabilidade em sucos digestivos intestinal dos insetos.Algumas modalidades preferidas da BtB ter removido proteinase c..

Anti-tripanossoma PEPTÍDEOS E USOS DOS MESMOS

A presente invenção fornece métodos de matar, de inibir o crescimento e / ou reprodução da inibição de protozoários parasitas cinetoplastidas com peptídeos sinal hidrofóbico seqüência e inclu composições ..

IMUNIZAÇÃO CONTRA profilático e terapêutico PROTOZOÁRIOS INFECÇÃO E DOENÇA

Polipeptídeo e vacinas polinucleotídicas eficaz para tratar ou prevenir a infecção de um mamífero, como um cão, um gato, ou um ser humano, por um protozoário.Métodos de tratamento e prevenção também são fornecidos, pol.

Biomarcador CÂNCER glicoproteína

A invenção refere-se glicoproteínas ter um glycoform câncer específicas. Específico para câncer de glycoforms são úteis no diagnóstico e terapêutica.

Aptâmeros como agonistas

Aptâmeros ácido nucléico são descritas neste documento, que pode converter um sinal para as células por crosslinking molécula de superfície de uma célula, induzindo de uma ou mais atividades biológicas pelas células, em servi ..

Antídotos para aptâmeros agonística

A presente invenção refere, em geral, para aptâmeros e antídotos para os mesmos e, em particular, para aptâmeros capazes de se ligar a e ativando as moléculas, tais como receptores (por exemplo, o receptor OX40 ..

De uma única célula biosensor para a medição de ligantes GPCR em uma amostra de teste

A presente invenção está relacionada com a detecção de ligantes GPCR em uma amostra de teste usando um biossensor única célula expressando uma GPCR. De preferência, a amostra de teste é derivado de uma biológicos ou ambi ..

DETECÇÃO DE DISPOSITIVOS DE TESTE E MÉTODOS DE FAZER E USAR O MESMO

Um artigo como um detector de biomolecular ou biossensor tendo uma superfície nonfouling nela inclui: (a) um substrato tendo uma porção de superfície, (b) uma camada de ligação na parte de superfície, e (c) pol um ..

PREVISÃO DE RESPOSTA AO CANCER THERAPEUTICS

Fornecidos aqui métodos para prever a resposta de um câncer a um agente quimioterapêutico usando perfis de expressão gênica. Em particular, os métodos para prever a resposta ao 5-fluo ..

CAPTURE RESINA ASSISTIDA DE CISTEÍNA modificadora de proteínas / peptídeos e DETERMINAÇÃO DA PRESENÇA E LOCALIZAÇÃO DE MODIFICAÇÃO

A resina conectados por ligação amida de sulfeto de piridil ou methylthiosulfonate pode ser conjugado com uma pós-traducionalmente proteína modificada / peptídeo para permitir a determinação de presença e tipo e optionall ..

Tratamento de câncer oncogênico RAS DRIVEN

Oncogênico câncer de Ras-driven é tratada com agente de ativação da via, interrompendo composto de Akt por Ras oncogênico, ativado Akt causando a fosforilação da eNOS na S1177 local de eNOS para oferecer ..

Fragmentos de anticorpos YHU PARA USO NA DETECÇÃO E TRATAMENTO DE CÂNCER

O assunto hoje divulgados fornece ligantes para a detecção de células e de imagem de câncer e tumores, e para entrega guiada de um agente ativo para as células cancerígenas e tumores. Em algumas incorporações ª ..

CARACTERIZAÇÃO DE GRP94 LIGANTE interações e purificação, triagem, e métodos terapêuticos RELACIONADAS

A matéria atualmente divulgados assunto divulga caracterização de interações entre ligantes e Hsp90 proteínas, incluindo GRP94, onde ligante de ligação para o N-terminal de ligação de nucleotídeos domai ..

IgG proteína de fusão Fc/HIV-gp120/C3d

Problema a ser resolvido: Para fornecer um imunógeno para induzir anticorpos que neutralizam um amplo espectro de isolados primários de HIV, e um método para induzir anticorpos anti-HIV usando o imunógeno. ; SOLU ..

HEDGEHOG sinalização e células-tronco cancerosas em neoplasias de células hematopoiéticas

A divulgação atual relaciona-se geralmente a métodos de tratamento de neoplasia maligna de células hematopoiéticas em um assunto com a administração para o assunto um antagonista do caminho Hedgehog (Hh), como um Smoothen (SMO) ..

PHOTOLABILE COMPLEXOS DE TRANSIÇÃO CAGED METAL E MÉTODOS DE UTILIZAÇÃO DO MESMO

A presente invenção fornece compostos da Fórmula I: (I), juntamente com composições compreendendo os mesmos e métodos de usar o mesmo, como para a terapia fotodinâmica no tratamento de câncer.

Composições e métodos usando moléculas de siRNA PARA TRATAMENTO DE gliomas

A presente invenção fornece pequeno RNA de interferência (siRNA) moléculas, composições contendo as moléculas, e métodos de usar as composições para o tratamento de gliomas.

Auto-anticorpos em A DETECÇÃO E TRATAMENTO DE CÂNCER

Métodos, kits e composições para a detecção e / ou tratamento do câncer baseada na detecção e / ou administração de um anticorpo, o que pode, opcionalmente, ser um anticorpo bispecific, tendo a imunorreação chara ..

Modulação da resposta imune por não-peptídeo polipeptídeos de resposta obrigatória estresse

A resposta ao estresse polipeptídeo recombinante que não tenha um domínio de ligação do antígeno, e métodos para usar a resposta ao estresse polipeptídeo recombinante para induzir uma resposta imune, por exemplo, um anti-tumo ..

COMPOSIÇÕES gosto azedo RECEPTOR E MÉTODOS

A presente invenção refere-se a receptores de sabor azedo e as composições e os métodos dos mesmos. Em particular, a presente invenção fornece ensaios e métodos de triagem para ligantes específicos para sour ..

RISCO DE CÂNCER PREDIÇÃO E TRATAMENTO DE SUCESSO

Fornecidos aqui métodos para prever a probabilidade de reincidência de um câncer usando perfis de expressão gênica. Métodos para desenvolver planos de tratamento para os indivíduos com câncer também são fornecidos ..

Cruzamento de espécies quimérico moléculas de RNA

Métodos para reduzir a expressão de pelo menos um gene de um patógeno intracelular em uma célula hospedeira são fornecidos, onde o método compreende introduzir em uma célula hospedeira um polinucleotídeo heterólogas ..

MÉTODOS DE INIBIÇÃO DE CRESCIMENTO câncer de células com inibidores HDAC E MÉTODOS DE TRIAGEM PARA INIBIDORES HDAC10

Métodos de inibir o crescimento de células cancerosas utilizando HDAC10 inibidores são fornecidos. Métodos de tratamento de câncer em um sujeito utilizando HDAC10 inibidores também são fornecidos. Em certas modalidades, pelo menos, um s..

Produção de anticorpos monoclonais em células B E USOS therof

O assunto hoje divulgados fornece métodos de inibição da resposta inata para hospedar um ativador mediada por sinais proliferativa em uma célula B primário. Em algumas modalidades um método é fornecido f..

AFFINITY SEPARAÇÃO DE DESLOCAMENTO MOLECULAR

Fornecidos aqui métodos para a identificação de moléculas que competir com um ligante para a ligação a uma proteína. O método compreende contatar um ligante com um proteoma para permitir que membros da proteína do prot ..

MÉTODO DE ENTREGA

A presente invenção refere, em geral, de silenciamento de RNA e, em particular, a um método de efetivação de entrega prevista para uma molécula de silenciamento de RNA usando uma molécula alvo que se liga a um surf de células ..

TERAPIA COMBINADA PARA O TRATAMENTO DE CÂNCER

Aqui divulgado é um método de tratamento de um tumor por administração ao assunto uma quantidade de tratamento eficaz de um anticorpo terapêutico e um agente alquilante.

Amilopectina copolímero biodegradável compreendendo ou glicogênio ADEQUADO PARA ENTREGA MATERIAIS ácidos nucléicos em células

A invenção está relacionada a um copolímero biodegradável, o que é adequado para a entrega de materiais de ácidos nucleicos em células, e que compreende uma amilopectina ou glicogênio e pelo menos um Polym catiônicos ..

Sistema composto biodegradável e A UTILIZAÇÃO DAS MESMAS

A invenção se refere a um sistema composto de pelo menos uma mistura biodegradáveis contendo pelo menos um Blockcopolyesterurethan biodegradável (PEU) e pelo menos um polihidroxialcanoato (PHA), OptionA ..

FORMULAÇÃO para induzir largamente reactivo NEUTRALIZANDO anticorpos anti-HIV

A presente invenção refere em geral, a uma formulação adequada para uso na indução de anti-HIV-1 anticorpos, e, em particular, a uma formulação compreendendo Toll like receptor (TLR) com agonistas HI ..

FORMULAÇÃO

A presente invenção refere, em geral, a uma formulação adequada para uso na indução de anti-HIV-1 anticorpos e, em particular, a uma formulação compreendendo uma forma prehairpin intermediário de HIV-1 e..

MÉTODOS DE FAZER FOLHAS DE CÉLULAS, TECIDOS E FOLHAS DE NAVIOS da engenharia de tecidos SANGUE

Modalidades de folhas de células, tecidos e vasos folhas engenharia de tecidos de sangue são fornecidos. Os métodos incluem a cultura de células em um andaime nanoimprinted revestido em condições de hipóxia para formar a..

MODELOS MOUSE

A presente invenção refere, em geral, para modelos animais apropriados para o teste imunógenos candidatos e, em particular, a bater-nos camundongos expressando cadeias pesadas e leves da membrana extern proximal ..

NÃO-INVASIVA ENERGY MÉTODOS E SISTEMAS PARA upconversion IN-SITU photobiomodulation

Produtos, composições, sistemas e métodos para modificar uma estrutura alvo que medeia ou está associado com uma atividade biológica, incluindo o tratamento de condições, distúrbios ou doenças medi ..

MODULADORES DE receptores olfativos

A presente invenção refere-se a polipeptídeos capazes de promover odorant receptor de localização da superfície celular e expressão de receptores olfativos funcional. A presente invenção também fornece ensaios ..

MÉTODOS PARA AGENTES DE CONTRASTE DE CARGA EM um lipossoma

A invenção compreende composições e métodos para carregar ambos os agentes de ressonância magnética de contraste e agentes terapêuticos em lipossomas, tais como lipossomas sensíveis a baixas temperaturas (LTSLs). Em cert ..

Sensíveis à temperatura PREPARAÇÃO lipossomal

Problema a ser resolvido: Para fornecer uma útil lipossomas nos métodos de administração de agentes ativos usando leve condições hipertérmico. ; SOLUÇÃO: Há desde que o lipossoma contendo um agente ativo a..

AGENTES TERAPÊUTICO COMPREENDENDO ELASTINA-LIKE PEPTÍDEOS

A presente invenção fornece agentes terapêuticos e composições que compreendem elastina, como peptídeos (ELPS) e proteínas terapêuticas. Em algumas modalidades, a proteína terapêutica é uma ag GLP-1 receptor ..

CHAPERONE-ASSISTIDA expressão da proteína E MÉTODOS DE USO

A divulgação atual fornece métodos de utilização de proteínas chaperone para a produção de proteína ativa como as codificadas pelos genes de clusters biossintética natural. Os métodos fornecidos h..

PERIFÉRICO BIOMARCADORES SANGUE PARA pneumonia intersticial idiopática e métodos de uso

A presente invenção fornece métodos para o diagnóstico de vários tipos de doenças. Especificamente, a divulgação nos fornece um painel de genes de diagnóstico, a expressão diferencial de mRNAs cuja o..

MÉTODOS DE MANIPULAR A sinalização celular

A divulgação prevê métodos de monitorização e / ou sinalização celular modulando e, especificamente, polinucleotídeos, polipeptídeos, células, ensaios, geneticamente modificados animais não-humanos, e métodos ..

N-TERMINAL MÉTODOS dimerização com BIS-AMINDINO ÁCIDO E DERIVADOS BIS-THIOIMIDATE

A invenção fornece métodos de alto rendimento de proteína dimerização utilizando altamente reativos bis-thioimidates que podem ser usados na fabricação de um potente anti-câncer de dímeros peptídeo.

HIV-1 ANTICORPOS

A presente invenção refere, em geral, ao HIV-1 anticorpos específicos e, em particular, a capacidade ampliada de neutralização do HIV-1 anticorpos específicos que visam a gp41 região proximal da membrana externa (MP..

Inibição da ativação do receptor endossomal TOLL-LIKE

A presente invenção refere, em geral, de reconhecimento de padrões receptores (PRRs), incluindo toll-like receptors (TLRs), e, em particular, a um método de induzida por ácido nucléico inibindo a ativação ..

COMPOSIÇÕES, MÉTODOS E KITS para eliciar uma resposta imune

A presente invenção refere-se a composições, métodos e kits para induzir uma resposta imune a pelo menos um antígeno CMV expressas por uma célula de câncer, em particular para tratar e prevenir canc ..

Conjugados preparado com agregado livre de proteínas

Uma proteína de ocorrência natural ou recombinante, especialmente um mutein de suínos oxidase de urato (uricase), que é essencialmente livre de grandes agregados podem ser prestados substancialmente não imunogênicos por conj ..

Engenharia de Tecidos

A presente invenção refere, em geral, a engenharia de tecidos e, em particular, a um método de prolongamento da vida útil de células adequado para uso em engenharia vascular. A presente invenção r..

Métodos para o tratamento de câncer e infecções patógeno usando células apresentadoras de antígenos carregado com RNA

A presente invenção refere-se a métodos para produzir um antígeno de células RNA-carregados apresentando (APC), dito método compreendendo a introdução em uma célula apresentadoras de antígenos in vitro RNA que codifica para uma immunomo ..

PEG-conjugados de urato oxidase e uso

A oxidase de urato de ocorrência natural ou recombinante (uricase) covalentemente acoplado a poli (etileno glicol) ou poli (óxido de etileno) (ambos referidos como PEG), onde uma média de 2 a 10 fios de PEG ..

COMPOSIÇÕES E MÉTODOS PARA AUMENTAR A ATIVIDADE DE RECEPTOR odorant

A presente invenção refere-se a polipeptídeos capazes de modular a ativação de receptores olfativos. Em particular, a presente invenção fornece polipeptídeos (por exemplo, tipo 3 rece actetylcholine muscarínicos ..

MicroRNA e uso na identificação de neoplasias de células B

Divulgados são sequências de ácidos nucleicos, incluindo sequências e sequências de cDNA microRNA, bem como vetores, bibliotecas de DNA, microarrays, e as células recombinantes compreendendo a seqüências de ácido nucléico descr ..

MÉTODO de induzir uma resposta anti-viral IMUNE

A presente invenção refere a um método de induzir uma resposta imune anti-viral. O método compreende administrar a um paciente em necessidade do mesmo um antígeno que induz a produção de antibodie ..

HEMATOPOÉTICAS STEM FATOR DE CRESCIMENTO DE CÉLULAS

A presente invenção refere, em geral, às células-tronco e, em particular, a uma célula-tronco hematopoiéticas (HSC) fator de crescimento e métodos de usar mesmo.

Aptâmeros RNA e métodos para identificar o mesmo

Aptâmeros RNA e métodos para a identificação da mesma são divulgados. Os aptâmeros RNA se ligam seletivamente os fatores de coagulação, os membros da família E2F, Ang1 ou Ang2 e usos terapêuticos e outros para o apt RNA ..

ANTICORPOS ANTI-CD19 e usos em distúrbios das células B

A invenção refere-se a composições imunoterápicos e métodos para o tratamento de doenças e distúrbios de células B em seres humanos, tais como, mas não limitado a, neoplasias de células B e autoimmun ..

ATUADOR INTEGRADO PARA ELETROFORESE GEL gota e análise molecular

A invenção é dirigida a um dispositivo atuador gota e métodos para integrar a análise de eletroforese em gel com a manipulação de amostra pré ou pós-analíticas, bem como outras análises moleculares processe ..

COMPOSIÇÃO E MÉTODOS DE provocando uma resposta imune

A presente invenção refere-se a composições, métodos e kits para induzir uma resposta imune, em particular, para induzir uma resposta imune a pelo menos um antígeno expresso por uma célula de câncer, dentro.

Urato-oxidase

A presente invenção refere, em geral, a urato oxidase (uricase) proteínas e moléculas de ácido nucléico mesma codificação. Em particular, a invenção se refere a uricase proteínas que são particularmente ..

MicroRNA VIRAL

A presente invenção refere, em geral, micro e RN Como. em particular, para microRNAs viral expressa por Herpes Simplex Vims 1 (HSV-1) ou vírus herpes simplex 2 (HSV-2), aos agentes que inibem a su ..

Trimodal TERAPIA DO CANCRO

Tipos de câncer são tratados com três tipos de agentes: um agente quimioterápico que induz linfopenia; um anticorpo inibidor para um marcador de superfície em células Treg, e uma vacina anti-câncer. Esta associaç ..

REGULAMENTAÇÃO CÉLULAS B E SEUS USOS

A presente invenção refere a um CD1dhigh fenotipicamente distintas CD5 + B subconjunto de células que regula células T mediada por respostas inflamatórias através da secreção de interleucina-10 (IL-IO). A inventar ..

INDOLINE ANDAIME SHP-2 INIBIDORES E MÉTODO DE TRATAMENTO CÂNCER

As preocupações invenção assunto métodos e compostos para a inibição da SHP2.Em uma modalidade, um composto da invenção tem uma estrutura química, como mostrado na fórmula I ou II: em que X, Y e Z são i..

Inibidores do proteassoma para seletivamente induzir apoptose em células de câncer

A presente invenção diz respeito compostos tendo atividade como inibidores de proteasomas e métodos de usar os compostos assunto. Em uma modalidade, um composto da invenção tem a estrutura química ..

SUBSTRATO-MIMETIC INIBIDOR AKT

Aqui divulgado é uma espécie de peptídeos e não-peptídeo inibidores da Akt, uma proteína oncogênica. Começando com um resíduo de Akt substrato alvo da GSK-3, os domínios funcionais do resíduo GSK-3 nós ..

A inibição da proteína tirosina fosfatase SHP2/PTPN11 POR NSC-117199 e análogos

Proteína tirosina fosfatase (PTP) SHP2 é uma PTP não-receptor que envolvidos na sinalização celular e regulação da proliferação celular, diferenciação e migração.SHP2 medeia a ativação de quinases ..

BIVM GENE (BASIC, IMUNOGLOBULINA-LIKE MOTIF VARIÁVEL CONTENDO), PRODUTOS transcricional, E USOS DOS MESMOS

A presente invenção fornece seqüências de polinucleotídeo, BIVM designado, e produtos de transcrição / translação obtida a partir das seqüências de polinucleotídeos da invenção. A invenção assunto ..

STAT3 agonistas e antagonistas e terapêuticas usos deles

A presente invenção refere-se a métodos de modulação, ou seja, agonizante ou antagonizar, Stat3 atividade (transdutor de sinal e ativador de Transcription3) de sinalização para uso em terapia genética. Inhibiti ..

C proteína quinase como alvo para o tratamento do vírus respiratório sincicial

A presente invenção diz respeito a um método de inibir vírus respiratório sincicial (RSV), infecção em um paciente através da diminuição da proteína quinase C endógena atividade (PKC) dentro do paciente. Preferab ..

DETECÇÃO DE PKC iota-como um biomarcador para tumorigênese BRAIN

Um método de detecção de tumorigênese do cérebro em um assunto, o método inclui as etapas de (a) obter uma amostra do cérebro do sujeito humano, (b) a detecção quantitativa ou semi-quantitativel ..

MÉTODO DE PKCIOTA inibição selectiva da

PKCiota inhibitor1 H-imidazol-4-carboxamida, 5-amino-1 - [2,3-dihidroxi-4-[(phosphonooxy) metil] ciclopentil] - [1-R (1a, 2SS, 3 ss, 4 a) ], (ICA-1), tem como alvo uma seqüência única (46 resíduos de aminoácidos ..

NAVIO INIBIÇÃO direcionar células-tronco hematopoéticas e INDUZIR hematopoese extramedular

A presente invenção diz respeito a inibição da expressão SHIP e / ou função em indivíduos mamíferos para dirigir HSC da medula óssea para outros sites no corpo (como o baço e / ou fígado), wher ..

Sistema de Foco passiva Campo Elétrico para In Vivo e In Vitro Applications

A presente invenção fornece um sistema e método de dirigir, concentrando-se, ou se concentrar cargas elétricas dentro de um campo elétrico definido para que estas taxas podem ser usados para exercer forças no celular ..

MÉTODOS E COMPOSIÇÕES PARA REDUZIR A ATIVIDADE DO RECEPTOR ATRIAL PEPTÍDEO NATRIURÉTICO E PARA TRATAMENTO DE DOENÇAS

Métodos, composições e dispositivos são fornecidos pela presente invenção para reduzir a atividade de um receptor de peptídeo natriurético e outros sinais.Tratamentos terapêuticos são fornecidas pelo uso de polynuc ..

MÉTODO E COMPOSIÇÃO PARA VIA CANÔNICOS MODULANTE WNT USANDO folato e inositol

A via de sinalização Wnt canônica está implicado em muitas doenças, incluindo defeitos do tubo neural, malformações dos membros, e defeitos cardíacos, transtornos de desenvolvimento associados com a exposição de álcool (feta..

VARIANTES hiperativa do 5-aminolevulinato SINTASE E MÉTODOS DE USO

A taxa de biossíntese de porfirinas em mamíferos é controlada pela atividade da enzima 5'-fosfato-dependente piridoxal 5-aminolevulinato sintase. Assumindo que o volume de negócios nesta enzima é controlle ..

ALPHA HELIX-MIMETIC USANDO UM ANDAIME 2,5-OLIGOPYRIMIDINE

Alfa-hélice-miméticos e métodos associados de fazer são fornecidos. Estes compostos são construídos usando um andaime 2,5-oligopyrimidine. O andaime semi-rígida detém lado individual da cadeia como resid ..

Moléculas de ligação do factor de crescimento

Moléculas do fator de crescimento de ligação tendo uma pluralidade de peptídeo loops ligado a um peptídeo não-orgânicos andaime, de preferência com pseudo-seis loops peptídeo amino ácido com quatro cadeias laterais de aminoácidos. T..

AGENTE DE VOLUME DE EXCLUSÃO PARA AUMENTAR A FORMAÇÃO DE EXTRACELLUAR MATRIX

Um método de melhorar a formação de matriz extracelular em cultura. Células em cultura secretam a maior parte do colágeno na mídia como procolágeno não transformados, ou seja, as células não se convertem procolla ..

Inibição da proliferação celular

Compostos de fórmula (I) e (II) são fornecidos como moduladores de Rb: Raf-1 interações que são potentes, disruptores seletiva de Rb: Raf-1 vinculativo. Métodos terapêuticos de usar os compostos, para exampl ..

AKT E clusterina como biomarcadores de resposta QUIMIOTERÁPICOS

Composições e métodos para a identificação de cânceres resistentes ao tratamento, devido à presença de níveis elevados Pakt e / ou superexpressão de AKT. Os métodos compreendem a detecção de fosforilada ativa ..

Materiais e métodos para prevenir ou tratar doenças neurodegenerativas ASSOCIADOS ABETA PEPTIDE ACUMULAÇÃO

As preocupações invenção assunto métodos para prevenir e / ou tratamento de doenças neurodegenerativas associadas com o acúmulo do peptídeo Abeta no tecido neural em um ser humano ou animal. O inventi assunto ..

MÉTODO DE ATIVAÇÃO DE CÉLULAS NK

A presente invenção fornece um método de mediação hipo-ativação de células NK.Métodos da presente invenção compreendem a administração a um sujeito uma quantidade efetiva de ampla atuação da fosfatase i..

MÉTODO DE ATIVIDADE SHIP MODULANTE

Um método de tratamento ou prevenção de um distúrbio imunológico, tais como doença do enxerto versus hospedeiro, em um assunto. O método inclui a administração de um inibidor de SHIP1, como 3a-aminocholestane, a uma subjetividade ..

Composto citotoxina e método de isolamento

A presente invenção diz respeito compostos derivados de tunicados das espécies Synoicum adareanum, bem como a composições farmacêuticas compreendendo estes compostos e métodos de uso. Extratos fro ..

Imunoterapia para o tratamento de amilóide Transtornos Relacionados ao Uso Usando Encapsulated peptídeos beta-amilóide

A presente invenção refere-se ao campo da química dos polímeros e, mais particularmente a peptídeos encapsulados e usa do mesmo.

Linha celular humana MAST E USOS DOS MESMOS

O assunto diz respeito a invenção ao desenvolvimento de uma linha celular humana mastro romance, USF-MC1. USF-MC1 é um precursor de mastócitos presentes no sangue do cordão umbilical humano (HUCB), que pode ser sustentada no blo ..

INDOLINE ANDAIME SHP-2 INIBIDORES E MÉTODO DE TRATAR CÂNCER

TRATAMENTO CÂNCER USANDO PEPTÍDEOS NATRIURÉTICO

A presente invenção inclui um método de utilização de quatro hormônios peptídicos para inibir o crescimento do câncer (s). A diminuição dramática no número de células de adenocarcinoma pancreático humano (ou seja, o typ ..

DENDROASPIS peptídeo natriurético para tratamento de câncer

É descrito um método de inibir o crescimento de uma célula de câncer usando Dendroaspis peptídeo natriurético (DNP), isolado a partir do veneno de cobra Mamba Verde com estrutura semelhante à ANP, com ou sem para ..

Inibição da SHIP para melhorar Colheita e Transplante de Células-Tronco

A presente invenção ensina a inibição da expressão SHIP, ou função para o aumento da eficácia do transplante autólogo de células-tronco. Em outra modalidade, a interferência com a função de navio pode ..

Actividade antiviral de ciclopenteno NITRO-ESTER E DERIVADOS

É descrito um método de síntese de novos compostos heterocíclicos opticamente puro usando Pd (0) catalisada ciclização intramolecular. Análogos de Ciclopentanos, como isoxazolina-2-óxido e furano, com si ..

NAVIO-Deficiência para aumentar a produção Progenitor megacariócitos

A invenção diz respeito a um método para aumentar os números progenitor megacariócitos e megacariócitos in vitro ou in vivo, suprimindo SH2-contendo inositol-5-fosfatase função (SHIP), em megakaryoc ..

Complexos de platina e métodos de uso

A presente invenção refere complexos de platina que apresentam células antitumor e / ou atividade antiparasitária. A invenção também refere-se a utilização de complexos de platina da invenção para tratar ..

MÉTODOS PARA INIBIR A PROLIFERAÇÃO DE CÉLULAS DE TUMOR

A presente invenção diz repeito aos métodos de inibição de funções biológicas STAT usando complexos de platina.

Valor Preditivo dos GENES EXCISÃO NUCLEAR PARA REPARO sobrevivência ao câncer

Pacientes que têm o câncer removido cirurgicamente estão em risco de recorrência, embora atualmente livre da doença. Pacientes com câncer de pulmão com maior atividade de um gene nuclear excisão de reparo chamado ..

Lysophospholipids como biomarcadores de câncer de ovário

Um método de usar um lysophospholipid bioativos (LL) como um biomarcador para detectar a presença e recorrência de câncer de ovário. Subespécies de LL, como lysophosphatidic ácido (LPA), lysophosphatidyli ..

Biochip de DNA e métodos de uso

A invenção assunto preocupações materiais e métodos para a detecção de sequências de ácidos nucleicos. Um aspecto da invenção diz respeito a uma base de silício "biochip", compreendendo ácidos nucléicos imobilizados nela. I..

Detecção de câncer de resistência de platina E MÉTODO DE SENSIBILIZAÇÃO

O estado de fosforilação das proteínas BAD é um determinante de ovário de resposta das células de câncer com a quimioterapia platina. Manipulação indireta do estado de fosforilação BAD influências cisplatina ..

SISTEMA AUTOMÁTICO DE CONCENTRAÇÃO DE PARTÍCULAS

Um sistema automatizado para a concentração de substâncias potencialmente prejudiciais de vários tipos de água ou outros líquidos não-viscosa para facilitar a detecção dessas substâncias é divulgada aqui. A automatizar ..

Canabinóide 2 (Cb2) Promotor de Receptor Gene e transcrições originais RNA em células B e métodos de uso

Canabinóides receptor 2 (CB2) é expresso em linfócitos B e está envolvida na regulação imune. Células B do baço de rato expressam três CB2 transcrições utilizando dois diferentes exons primeiro. Periféricos humanos ..

Aplicação Oncotherapeutic de Inibidores de transportadores de glicose de alta afinidade

A invenção assunto preocupações materiais e métodos para tratar distúrbios oncológicos em uma pessoa ou animal com qualquer agente ou composto que inibe a absorção de glicose em uma célula. A invenção assunto ..

Biomarcadores para RESPOSTA PREVENDO à terapia imunossupressora

A invenção assunto preocupações métodos e materiais para avaliar a probabilidade de um paciente de capacidade de resposta a uma terapia imunossupressora. A invenção assunto é contemplado para uso com pacientes ..

METAL-ENHANCED bioluminescência: UMA ABORDAGEM PARA ACOMPANHAMENTO PROCESSOS BIOLÓGICOS bioluminescentes

A presente invenção refere-se a plasmon de superfície acoplado a bioluminescência, onde a partir de uma emissão bioluminescentes casais química bioluminescente reação a plasmons de superfície de partículas metalizadas do ..

Alta afinidade ANTICORPOS SEA RECOMBINANTE lampreia SELECIONADOS POR UMA PLATAFORMA DISPLAY LEVEDURA DE SUPERFÍCIE

A presente invenção refere-se a uma superfície de exibição vetor de levedura (YSD) para a expressão de proteínas VLR pela levedura, em que o vetor inclui sequências de nucleotídeos codificando os segmentos da floculação de leveduras ..

ENGENHARIA de amplo espectro RESISTÊNCIA CONTRA A DOENÇA haustório-FORMING PATÓGENOS DE USAR RPW8 como veículo de entrega

A presente invenção refere-se ao aumento da expressão de proteínas RPW8 causando um aumento do nível do RPW8 proteínas na membrana extrahaustorial com a indução subseqüente de inibição do patógeno ..

ELECTROADDRESSING e no cinema-Bioprocessamento com estímulos de resposta hidrogel-FORMING POLÍMEROS

Métodos para a geração de hidrogéis formada por eletrodeposição de um polímero electroaddressable são descritos. Os hidrogéis podem conter uma ou mais populações de células electroaddressed ou electroad ..

UBIQUILIN REGULAMENTO DO ENDOPROTEOLYSIS presenilina, e supressão de poliglutaminas toxicidade induzida EM CÉLULAS

Uso de ubiquilin é descrita, incluindo a utilização para reduzir a fragmentação da presenilina 1 e 2 e para modular [gama]-secretase componentes, Pen-2 e Nicastrin, bem como a utilização de indu ..

Proteínas contendo folhetos poliglutaminas EXPANDIDO INDUZIR FRAGMENTAÇÃO MITOCONDRIAL interrompendo FUSION MITOCONDRIAL

Tratos poliglutaminas expandida são mostrados para ser uma causa de perturbação da função mitocondrial e, portanto, uma causa de toxicidade celular e morte celular e uma causa de várias doenças ou distúrbios relacionados ..

Recombinante Duplo-Stranded Phage RNA, e uso da mesma

Um recombinante dupla fita de RNA do fago (dsRNA) expressa dsRNA codificados os genes em células eucarióticas. Fago recombinante dsRNA são úteis para a expressão de dsRNA passageiros codificação expressão cassetes ..

Entrega prevista para SONDAS PARA IMAGING IN VIVO CELULAR IMAGING

A presente invenção refere-se a testes de imagem compreendendo immunoliposomes que encapsulam auto-extinguindo as concentrações de radicais livres estáveis ou agentes relaxação, alto contraste, como nitroxides ..

FOLDING MELHORADO de proteínas recombinantes VIA co-expressão de chaperonas Archaea

A presente invenção refere-se a produção de proteína recombinante e, mais especificamente, aos métodos para a recuperação de proteínas bioativas pasta adequadamente, expressando genes acompanhante de A. extremofílica.

CONJUNTOS PARA APRESENTAÇÃO FIBROSAS ANTICORPO, E ANÁLISE antigênica multiplexados usando os mesmos

Fibras Biofunctionalized incluindo uma plataforma de fibra e uma proteína histidina-tag e, opcionalmente, um anticorpo. A quitosana é uma fibra útil como plataforma de fibra. A plataforma de fibra podem ser tratados sagacidade ..

E via biossintética genes necessários para a biossíntese do ácido TROPODITHIETIC IN SILICIBACTER TM1040

Produção e utilização de um composto que contém enxofre, ácido tropodithietic (TDA), a partir do Silicibacter Roseobacter sp. TM1040 é descrito. Especificamente, uma via de biossíntese e regulação de TDA bi ..

Resistente à radiação MUTANTES DE UM ARCHAEON halofílicos E USOS DOS MESMOS

A presente invenção refere-se a variantes do modelo halophile Halobacterium sp.NRC-1 que tenham sido expostos a ciclos de irradiação com altas doses de 18-20 MeV elétrons. Estes novos isolados h..

CONVERSÃO DE JUST-CONTÍNUO filmes metálicos sobre substratos PARTÍCULAS GRANDES PARA METAL-ENHANCED FLUORESCÊNCIA

A presente invenção refere a um método de produção de filmes de prata com nanopartículas de grandes rachaduras causadas por anaeróbios durante recozimento para proporcionar superfícies que apresentam aumento de metal reforçado f..

Voltagem-dependentes FLUORESCÊNCIA METAL-ENHANCED quimioluminescência, OR bioluminescência MÉTODOS E SISTEMAS

Na presente invenção, é demonstrado pela primeira vez, a influência da corrente elétrica sobre a capacidade de plasmons de superfície para amplificar as assinaturas de fluorescência. Uma corrente contínua aplicada ac ..

TRIGGER MICROONDAS quimioluminescência METAL-ENHANCED (MT MEC) e controle ESPACIAL E TEMPORAL DE MESMO

A presente invenção refere a um método de estruturas utilizando recursos de imagens e emissões plasmonic de superfícies metálicas causado por químicos quimioluminescência baseado e wherei reações biológicas ..

PLANTAS COM expressão reduzida de FOSFATASE TIPO 2C gene de resistência PATÓGENO ENHANCED

A presente invenção refere a um método para regular um baixo Arabidopsis proteína fosfatase tipo de gene 2C, referido como "defesa-associado tipo proteína fosfatase 2C um" (DAPP1) que a função ..

Glicosilação TERAPIA ANTICORPO ENGINEERED

A presente invenção é atraído para os métodos de gerar um anticorpo glicosilação de engenharia, e usando o anticorpo glicosilação de engenharia para o tratamento de um paciente, particularmente um paciente de câncer ou a..

A NOVEL COMPOSIÇÃO DE MATÉRIA E MÉTODO PARA ESTIMULAR O crescimento de microrganismos benéficos

A invenção descreve uma composição de matéria romance obtido das folhas de plantas verdes, que é útil na promoção do crescimento de microrganismos benéficos. Especificamente, que a invenção d..

COMPOSIÇÕES E MÉTODOS UTILIZANDO FRAGMENTOS BETA da fibrina CADEIA DA CADEIA BBETA de fibrinogênio

A composição, incluindo uma seqüência de peptídeos da fórmula SSX1-X2, a seqüência de peptídeos correspondendo a uma seqüência de aminoácidos de um fragmento de cadeia beta de uma cadeia de fibrina Bbeta de fibrinogênio, onde ..

ZAP-70 AS PROGNÓSTICOS E MODULADOR DA FUNÇÃO DE CÉLULAS T efetoras

Nesta aplicação, é descrito um romance, a análise de multiparâmetros de TCR-coupled sinalização e função em repouso e ativado ingênuo e CD4 células T de memória, revelando uma base bioquímica para imunol ..

ERG-1 Peptídeos e Polinucleotídeos e seu uso no tratamento e diagnóstico da doença

A presente invenção refere-se a fragmentos de péptidos e polinucleotídeos de ERG-1, e em particular, humana ERG-1a (HERG-1a) e suas isoformas, e seu uso no tratamento e diagnóstico da doença, esp ..

COMPOSIÇÕES E MÉTODOS DE USO DE EPB1 E ERBB3 Binding Protein

Inibição da proliferação de células de câncer hormônio refratário próstata é alcançado pela administração EPB1, uma proteína ErbB3 ligação, em combinação com outra terapia anti-proliferação, tais como ..

Vacinas e terapias imunomoduladoras para Tularemia

A presente invenção refere-se a cepas atenuadas de Francisella tularensis a partir do qual genes na via de biossíntese de nucleotídeos guanina foram suprimidos e aos métodos para fazer os mutantes. T..

MICROCIN H47 SISTEMA DE SELEÇÃO DE PLASMÍDEO

A presente invenção refere geralmente aos sistemas de expressão estabilizada plasmídeo. Os sistemas de expressão estabilizada compreende um plasmídeo vetor de expressão que inclui um sistema de manutenção de plasmídeo (PM..

Mama proteína resistência ao câncer (BCRP) anticorpos

A Breast Cancer Resistance Protein é descrito, bem como a codificação de cDNA disse proteína. Esta proteína foi encontrada para conferir resistência a medicamentos quimioterápicos para câncer.

Fator antiproliferativo romance e métodos de uso

Um fator romance antiproliferativa compreendendo um glicopeptídeo é divulgada.Em modalidades específicas, o fator antiproliferativo romance está associada com a bexiga. Composições, kits de diagnóstico e r..

IMUNOGLOBULINA CONSTANT REGIÃO FC AGENTES ligação ao receptor.

Compostos substituição IVIG são derivados de criação recombinante e / ou bioquímicos de imunologicamente biomimético ativo (s). Estes compostos de substituição são, então, selecionados in vitro para avaliar cada subs ..

CLONAGEM EXPRESSÃO RAPID de anticorpos monoclonais humanos FROM células B de memória

O presente pedido fornece métodos para a produção de anticorpos monoclonais humanos sem o uso de tecnologia de hibridoma, anticorpos produzidos usados os métodos descritos, e métodos para usar os anticorpos ..

COMPOSIÇÕES FATOR VIII E MÉTODOS

A presente invenção fornece métodos de aumentar a meia-vida e / ou atividade específica de fator VIII. Mais especificamente, a invenção fornece métodos de aumentar a meia-vida e / ou especificações ..

NOVEL HUMANOS receptor de andrógeno ALTERNATIVA VARIANTES SPLICE AS biomarcadores e alvos terapêuticos

A presente invenção refere-se a novas variantes de receptor de andrógeno splice (AR3, AR4, AR4b, AR5 e AR8) e variantes e fragmentos dos mesmos que têm um papel na progressão do andrógeno independente p..

COMPOSIÇÕES E MÉTODOS PARA O CAMINHO resposta imune inata

Doenças auto-imunes são a conseqüência de interações complexas entre um mosaico de fatores genéticos do hospedeiro e os elementos etiológicos. Doença celíaca (DC) é uma doença auto-imune prevalente em 1% do gen ..

Métodos para tratar cânceres e doenças associadas a 4-1BB (CD137) EXPRESSÃO

A presente invenção refere-se ao papel de 4-1BB (CD137) ligante e anti-4-1BB (CD137) de anticorpos no tratamento de cânceres e doenças associadas com o 4-1BB (CD137) de expressão. Mais particularmente, ..

ENGINEERED TIPO IV pilin de Clostridium difficile

A presente invenção refere-se a engenharia Clostridium difficile tipo IV pilin (tfp) genes, proteínas do tipo IV pilin que pode servir como um marcador diagnóstico para a identificação de pacientes infectados com o ..

CO-MÉTODOS PARA SINALIZAÇÃO tratamento de câncer

Aqui previsto é um método de tratamento de uma doença neoplásica em um indivíduo em necessidade de tal tratamento, compreendendo as etapas de: a expansão de linfócitos T in vitro d; priming Natural Mate células em vit ..?

MAGE-A3/HPV 16 VACINAS PEPTIDE de cabeça e pescoço

A presente invenção refere-se a antígenos de Tróia, e composições imunogênicas compreendendo os antígenos Trojan. A presente invenção também se refere a métodos de gerar uma resposta imune em um tóp ..

TARGETING BIOSSÍNTESE NAD IN patógenos bacterianos

O surgimento de patógenos multirresistentes exige a busca de novos antibióticos agindo sobre alvos previamente inexplorada. Nicotinato mononucleótido adenylyltransferase da família Nadd, um ..

Domínios de ligação do antígeno a partir de peixes

Um processo para a produção de um domínio de ligação de antígeno antígeno específico usando um hospedeiro transformado contendo uma seqüência de DNA que codifica o antígeno expresso domínio antígeno específico de ligação, onde ..

GENE RESPOSTA AO COMPLEMENTO 32 (RGC-32) NA DOENÇA

A invenção refere-se a anticorpos que se ligam a um fragmento do gene Response to Complemento-32 (RGC-32), bem como métodos de usar estes anticorpos.Métodos particulares de usar os anticorpos de ..

RETINAMIDE NOVEL metabolismo do ácido retinóico AGENTES BLOQUEADORES

Agentes ácido retinóico metabolismo de bloqueio (RAMBAs). O RAMBAs pode ser usado para o tratamento de câncer, incluindo câncer de mama e próstata. Métodos para a preparação RAMBAs retinamide romance. Os métodos inc ..

Não-hemolítico CLYA para excreção DE PROTEÍNAS

A divulgação abaixo fornece um sistema de exportação de proteínas não-hemolítica utilizando variantes de proteínas membro HlyE família para produzir eficientemente proteína recombinante a partir de uma célula hospedeira. Em um emb preferida ..

Proteínas fluorescentes E USOS DOS MESMOS

A presente invenção proporciona novas proteínas fluorescentes. Em aspectos particulares da invenção, uma nova proteína fluorescente da invenção tem um aumento no rendimento quântico. Em particular, outros ..

ANDRÓGENOS INATIVAÇÃO RECEPTOR CONTRIBUI PARA antitumoral EFICÁCIA DE INIBIDORES CYP17 no câncer de próstata

Fornecidos são métodos de inibição da CYP17 em um mamífero, como um ser humano, que incluem administrar uma quantidade eficaz de pelo menos um inibidor da CYP17, como VN/124-1, VN/125-1, VN/85-1, VN / 87-1 e / ..

MÉTODOS E SISTEMAS PARA TRANSFERÊNCIA DE PURIFICAÇÃO e / ou manipulando ÁCIDOS NUCLÉICOS

A divulgação fornece métodos, sistemas e dispositivos de purificação, transferência ou manipulação de ácidos nucléicos, mantendo a relação espacial 2D dos ácidos nucléicos como eles estavam presentes ..

EXPRESSÃO celulase ENHANCED IN S. DEGRADANS

A invenção fornece organismos e métodos de uso e tornando os organismos com expressão celulase reforçada.

PEPTÍDEOS PARA TRANSPORTE DE THERAPEUTICS E SEUS PORTADORES DE MODELOS MOUSE E SERES HUMANOS

Um sistema de entrega prevista para os agentes (por exemplo, sondas moleculares, agentes de diagnóstico, agentes terapêuticos, agentes de imagem, de pesquisa ou de análise de compostos, enzimas, peptídeos, proteínas, lipídios, lipoprot ..

Processo para a preparação da Beta e Alpha Cryptoxanthin

A presente invenção refere-se a um processo para converter luteína e / ou ésteres de luteína a (3R) - [beta]-criptoxantina e (3R, 6'R) - [alpha]-criptoxantina, adequada para consumo humano como supplem dietética ..

PROTEASES PROJETADA PARA PURIFICAÇÃO DE AFINIDADE E PROCESSAMENTO DE PROTEÍNAS DE FUSÃO

A presente invenção é direcionada para a identificação de um prodomínio protease que é capaz de ligar uma protease correspondente com alta afinidade. O prodomínio protease da presente invenção ..

Radioativamente marcado DERIVADOS DE ciclopropano Tropanos DAT afim

A invenção refere-se radioativamente marcado derivados de ciclopropano Tropanos DAT afim adequado para o quantitativo, imagem não-invasivo de transportadores de dopamina estriatal e extrastiatal (da..

APARELHO, MÉTODO E SISTEMA DE GEL PARA ELETROFORESE ANALÍTICO e preparativa

A presente invenção refere a um aparelho de eletroforese em gel que compreende uma câmara para receber meio de eletroforese, um sistema de gel removível, que é organizado na câmara de gel, tendo uma sepa ..

Membranas ativa microfluídicos

A presente invenção refere a uma membrana biofabricated atividade microfluídicos (AMM) em uma rede microfluídicos de um dispositivo micro e um método para a biofabrication em situ de tal microfluidi um ..

Esparsamente Cross-Linked NANOGELS: A estrutura do polímero NOVEL de sequenciamento de DNA MicroChannel

A presente invenção é geralmente dirigida a novos materiais poliméricos para uso na separação eletroforética de ácidos nucléicos. Em particular, os novos materiais poliméricos são escassamente reticulado ..

Peptídeos, Peptidomimetics e inibidores de molécula pequena do vírus Epstein-Barr Mediated processo de fusão e entrada

São divulgadas composições e métodos para modular Epstein-Barr vírus A (EBV) em um paciente. As composições podem incluir peptídeos ou peptidomimetics que estão relacionados com a GP42 e função ..

AUTO-MONTAGEM DE SISTEMAS E MÉTODOS DE PEPTÍDEOS

A presente invenção fornece um sistema de peptídeos auto-montagem que utiliza uma seqüência bioativos que aumenta a eficiência de transfecção. Em particular, a presente invenção fornece composições a..

Peptídeo sintético e conjugados de peptídeos e métodos de acoplamento RELACIONADOS TECIDO VIA enzima transglutaminase

Peptídeos e seus conjugados compreendendo um ou mais agentes bioativos que pode ser acoplado a um tecido através de uma transglutaminase e métodos relacionados.

COMPOSIÇÃO E MÉTODO PARA A auto-montagem e mineralização do peptídeo-anfifílicos

A presente invenção é direcionada a uma composição útil para fazer auto-montados de forma homogênea mineralizado peptídeo anfifílico nanofibras e géis de nanofibras. A composição é geralmente uma solução ..

POLÍMEROS DE ÁCIDO CÍTRICO

A presente invenção fornece polímeros (por exemplo, polímeros elastoméricos ácido cítrico) e métodos de fabricação e uso desses polímeros (por exemplo, como uma plataforma biologicamente ativos molécula de entrega). Em certos ..

MÉTODOS E COMPOSIÇÕES PARA GERAÇÃO DE BACTÉRIAS esporulação DEFICIENTE

A presente invenção refere-se a métodos e composições para a engenharia de esporulação células bacterianas, particularmente uma célula da Clostridia classe. Em particular, a presente invenção refere-se à ..

ANTI-CANCER COMPOSTOS

A presente invenção refere-se a anti-câncer de compostos, métodos para a sua descoberta, e seu uso terapêutico. Em particular, a presente invenção fornece análogos do composto anti-câncer conhecidos ..

Novel biodegradáveis elastoméricos Scaffold para engenharia de tecidos e métodos de espalhamento de luz Fingerprinting para testar o mesmo

A presente invenção é direcionada a um polímero biocompatível romance que pode ser usado na engenharia de tecidos. Mais especificamente, a especificação descreve métodos e composições para fabricação e uso ..

Potente e seletivo NEURONAL ÓXIDO NÍTRICO SINTASE COM INIBIDORES permeabilidade da membrana MELHORADO

Compostos e composições relacionadas e métodos que podem ser usados para inibir a sintase neuronal do óxido nítrico e como podem ser empregados no tratamento de várias doenças neurodegenerativas.

COMPOSIÇÕES E MÉTODOS PARA INDUÇÃO DE TOLERÂNCIA antígeno-específica

A presente invenção utiliza partículas transportadora para apresentar peptídeos de antígenos e proteínas ao sistema imunológico de tal forma a induzir a tolerância antígeno específico. A partícula transportadora é projetado i..

MÉTODO DE MODULANTE HSF-1

A presente invenção é dirigida a métodos de modulação da atividade HSF1 compreendendo modificação da acetilação do domínio de ligação ao DNA do HSF1.

Autoprocessing cisteína protease de Proteínas de Fusão

Divulgados são proteínas de fusão, polinucleotídeos que codificam as proteínas de fusão divulgada, e métodos para expressar e autoprocessing das proteínas de fusão divulgada para obter uma proteína alvo. O ..

MANIPULAÇÃO DE CANAIS DE ION NEURONAL

A presente invenção fornece composições e métodos para a manipulação de canais iônicos. Por exemplo, a presente invenção refere-se a Parkinson e outras doenças neurológicas e condições, ..

POLIVALENTE RNA nanopartículas COMPOSIÇÕES

A presente invenção diz respeito as nanopartículas funcionalizadas com RNA duplex para uma variedade de usos, incluindo mas não limitado a regulação dos genes.Mais especificamente, a divulgação fornece uma nova estra ..

INTERFERÊNCIA TARGET DNA COM crRNA

A presente invenção fornece métodos, sistemas e composições para interferir com a função e / ou presença de uma seqüência de DNA alvo em uma célula eucariótica (por exemplo, localizado in vitro ou em uma subjetividade ..

MÉTODOS E COMPOSIÇÕES para isolar Ácido Nucleico

A presente invenção refere-se a composições e métodos para isolamento e purificação de ácidos nucléicos. Em particular, a presente invenção refere-se a métodos de isolamento de ácidos nucléicos a partir de células para uso ..

INIBIÇÃO E TRATAMENTO DE CÂNCER DE PRÓSTATA METÁSTASE

A presente invenção fornece compostos e métodos de inibição e tratamento do câncer de próstata metastático. Os compostos incluem inibidores MEK4. Em um outro aspecto da invenção fornece métodos de i..

STRIP FLUXO LATERAL E USOS DOS MESMOS

A presente invenção refere-se a sistema de análise de fluxo laterais strip e usa do mesmo. Em particular, a presente invenção refere aos sistemas de fluxo lateral ensaio para a detecção simples e barato o..

NOVEL baseado em peptídeo suportes para a regeneração da cartilagem E MÉTODOS PARA SUA UTILIZAÇÃO

Divulgados neste documento são moléculas de peptídeo anfifílico romance e composições composto por uma seqüência de peptídeo que não covalentemente liga o fator de crescimento TGF-ß1. Também divulgados são os métodos de usar estes p..

Multiplexados ARRAYS biomolécula FEITA POR POLÍMERO litografia PEN

Métodos de biomoléculas padronização múltiplas sobre uma superfície são divulgados. O método inclui uma disposição de tinta de caneta de polímero, onde dicas são selecionados tinta com tintas que compõem a biomoléculas, e transfe ..

Interpenetrando MATRIZES E USOS DOS MESMOS BIOMATERIAL

A presente invenção refere a matrizes (eg, alginato de fibrina-matrizes; fibrina-alginato matrigel-matrizes) para a cultura de células, órgãos (por exemplo, ovário, ou mesmo fragmento), células e agregados celulares ..

BIOMARCADORES para câncer de próstata

A presente invenção refere-se a composições e métodos para a detecção, tratamento e empiricamente investigando o de próstata. Em particular, a presente invenção fornece composições e método ..

MÉTODOS PARA TRANSFERÊNCIA ácidos nucléicos em células

A presente invenção fornece métodos para aumentar a transferência de ácidos nucleicos nas células. Em particular, a presente invenção prevê a utilização de inibidores da HDAC6, uma histona citoplasmática ..

Não enzimático DETECÇÃO DE DNA genômico BACTERIANA

A presente invenção refere-se a métodos para detectar a presença de um ou mais analitos alvo, biomoléculas por exemplo, em uma amostra. Em particular, a presente invenção refere-se a um método que ut ..

Auto-montagem de Peptide-anfifílico Nanofibras em condições fisiológicas

Compostos peptídeo anfifílico, composições e métodos para a auto-montagem ou formação de rede de nanofibras em condições neutras ou fisiológicos.

DETECÇÃO DE ÁLCOOL DE EXPOSIÇÃO MATERNA

A presente invenção fornece métodos, composições e sistemas para a detecção in utero a exposição ao álcool através da detecção de mudanças no nível de expressão de biomarcadores determinados (por exemplo, no tecido placentário). No ce ..

TRANSTORNOS alélica causada por mutações em TRPV4

A presente invenção fornece métodos, kits e composições para a detecção de mutações no receptor transiente canal de cátions potencial, V da subfamília, membro 4 (TRPV4). Em particular, as mutações são detec ..

SUPERFÍCIE IMOBILIZADOS Peptóides ANTIMICROBIANA

Immobilizable compostos antimicrobianos incorporando componentes antimicrobianos e / ou anti-incrustantes, como pode ser aderido a estruturas de dispositivos e componentes diversos.

Auto-montagem de peptídeos anfifílicos e métodos relacionados para a entrega do fator de crescimento

A invenção proporciona peptídeos que são capazes de fatores de crescimento de ligação, bem como os peptídeos anfifílicos compreendendo alguns desses peptídeos, montagens micelar de anfifílicos tais e relacionados conheci ..

LABEL-FREE biossensores LASER COM BASE FEEDBACK DISTRIBUÍDO

Um biossensor baseado em uma vertical a laser emitindo distribuídos feedback, (DFB) é divulgado. Em uma configuração, o laser DFB compreende uma réplica-moldado, ralar um ou dielétrica bidimensional ..

Alteradas Localização Intracelular de BRK / Sik proteína quinase tirosina em tumores humanos de próstata

A invenção fornece métodos para a detecção de condições anormais da próstata, como a hiperplasia prostática benigna (BPH), neoplasia intra-epitelial prostática (PIN) e adenocarcinoma, em um animal de co ..

Anti-Antiogenic Fragmentos de Fator Pigment Epitélio-Derived (PEDF)

A presente invenção fornece anti-angiogênico derivado do fator de epitélio pigmentar derivados (PEDF) composições farmacêuticas compreendendo os peptídeos e métodos de prevenção de angiogênese. Tais m..

TRIDIMENSIONAL BIORREATORES microfabricated com o eMbedded rede capilar

Em um aspecto, a presente invenção usa estereolitografia projeção micro para gerar redes microvascular tridimensional que são capazes de apoiar e fomentar o crescimento de uma população celular ...

Neutralização de toxinas estafilocócicas E ESTREPTOCÓCICAS

Bactérias aureus e Streptococcus segregam várias toxinas que atuam como superantígenos, estimulando uma grande fração de células T do hospedeiro. A ligação das toxinas aos domínios variáveis de T cel ..

PEPTÍDEOS E REGULAMENTAÇÃO dos canais de cálcio

Canais de cálcio podem ser regulados por proteínas gama natural. Aqui divulgamos incorporações de composições e métodos, particularmente envolvendo pequenos peptídeos que são capazes de regular c. cálcio.

RHO1 Gamma-ácido butírico Amino C Receptor de anticorpos específicos

Esta invenção fornece anticorpos imunologicamente específicos para rho1-GABAC proteína receptora. A invenção também fornece métodos de fabricação e métodos de usar disse anticorpos e kits contendo o ..

Produção de células-tronco neurais a partir de tecido da medula óssea e uso

A invenção fornece reagentes e métodos para a preparação de mamíferos mesenquimais derivadas de células-tronco neurais, especialmente autólogo mesenquimais derivadas de células-tronco neurais, composições dos mesmos, e método ..

USOS DE ANTICORPO BISPECIFIC Células Dendríticas COATED pulsadas com antígenos e GM-CSF na regulação imune

GM-CSF administrada antes da imunização exercido um efeito supressivo sustentada contra a indução de miastenia gravis (MG). Esta supressão foi associada com baixos níveis de auto-anticorpos no soro, ..

MÉTODO DE PROMOÇÃO POR ATIVIDADES neurogênese secretase MODULANTE

Esta invenção fornece métodos e reagentes para promover a neurogênese, pela proliferação de células-tronco neurais de modulação e de diferenciação.Particularmente, esta invenção fornece métodos e reagentes para ..

COMPOSIÇÕES E MÉTODOS PARA PREVENIR CÂNCER COM CUPREDOXINS

A presente invenção revela métodos e materiais para a entrega de um composto de carga em uma célula cancerosa. Entrega do composto de carga é realizado pelo uso de proteína de transdução de deri domínios ..

Hemicelulose enzimas que degradam

A divulgação atual fornece métodos para a conversão da hemicelulose em açúcares fermentáveis usando enzimas isoladas de Prevotella bryantii. Hemicelulose enzimas que degradam incluir uma endoxyla ..

SÍNTESE concepção e avaliação de procaspase COMPOSTOS ATIVANDO AS PERSONALIZADO drogas anti-câncer

Composições e métodos são divulgados no incorporações referentes à indução de morte celular, como nas células cancerosas. Compostos e métodos relacionados para a síntese e utilização, incluindo o uso de com ..

ESTÍMULOS-responsivo copolímeros baixa solubilidade hidrogel DE N-isopropil acrilamida e MÉTODO DE SÍNTESE

Estímulos-resposta modalidade preferida de baixa solubilidade em composições de copolímero de hidrogel da invenção incluem N-isopropilacrilamida polimerizados e monômeros insolúveis em água ou unidade oligômero repetir ..

INFERTILIDADE polimorfismo de deleção ASSOCIADOS DEFB-126

O presente pedido fornece métodos de diagnóstico para determinar o estado de fertilidade de um indivíduo do sexo masculino, avaliando seu estado DEFB-126 fenotípica e genotípica. A presente invenção refere ..

HUMANOS SINGLE-CELL CADEIA RECEPTORES T

A solúvel humano único de cadeia receptor da célula T (TCR), tendo a estrutura: PA2-L-Vss ou Vss-L-PA2, onde L é um peptídeo linker que liga Vss com Va, Vss é uma variável TCR região ss, e PA2 é um TCR ..

Utilização de polipeptídeos da família cupredoxin em cancertherapy.

Fatores citotóxicos tendo uso na modulação da morte celular, e sua utilização em métodos de tratamento de condições de necrose ou apoptose relacionados são divulgados. A invenção também se refere aos métodos para identifyin ..

COMPOSIÇÕES E MÉTODOS PARA SINALIZAÇÃO INIBIÇÃO DE PROTEÍNAS Ga

A presente invenção compreende composições e métodos para inibir especificamente a sinalização através Ga13, Gai e Gaq subunidades.

ACTIVATED células-tronco mesenquimais PARA A PREVENÇÃO E REPARAÇÃO DE estados inflamatórios

Citocinas inflamatórias por exemplo, IFN-? servir como estímulo para iniciar a atividade imunossupressivos MSC in vivo. Outras citocinas inflamatórias, como TNF alfa, o hemoxygenase molécula I, e ligadura TLR ..

REGULAMENTO DO apoptose por NEURAL VARIANTES SPLICE ESPECÍFICAS DE IG20

Pró-apoptóticos de sinalização causada por baixo de modulação de KIAA0358 ou expressão de IG20-SV4 efetivamente induz a apoptose espontânea e sensibilização para TNFa induzida por apoptose em células de neuroblastoma. Me ..

Adequação de ensaios e métodos associados

A presente invenção provê um ensaio para determinar a aptidão bioquímico de uma espécie bioquímicos em uma entidade replicante mutante biológico em relação ao seu predecessor. A presente invenção fu ..

Gene de soja para resistência a Aphis glycines

Aphis glycines uma resistência gene RAG2 é permitido aqui, junto com métodos para identificar sua presença usando seleção assistida por marcadores. A cultivar de G. max ter resistência a Aphis glycines con ..

PAK1 AGONISTAS E MÉTODOS DE USO

A presente invenção é dirigida a Pak1 agonistas e métodos de uso.

Alta afinidade TCR proteínas e métodos

Receptores de células T (TCRs) que têm maior afinidade para ligante que TCRs tipo selvagem são fornecidos. Estes TCRs alta afinidade são formados por células T mutagenizing uma seqüência de proteína receptor de codificação para gerar ..

Método de modulação do canal de sódio ou controlar atual por espécies reativas de oxigênio (ROS) provenientes de mitocôndrias

Método de modulação do canal de sódio ou controlar atual de uma célula inclui induzindo mitocondrial de espécies reativas de oxigênio (ROS) de produção na célula.

Identificação e utilização de inibidores da síntese de proteínas PEPTIDE

A presente invenção revela composições de inibidores peptídicos da síntese de proteínas, e os métodos de identificação de inibidores de peptídeo que são capazes de inibir a síntese de proteínas através de uma inter ..

MUTANT HYPERVIRULENT de Agrobacterium tumefaciens

Esta divulgação se refere a um mutante Agrobacterium tumefaciens que é funcionalmente eliminados para o gene atu1060 que codifica a sintase di-GMP cíclico Atu1060, bem como métodos para seu uso em tra ..

Mycoplasma hyopneumoniae imunogênica Polipeptídeos

Polipeptídeos Mycoplasma hyopneumoniae e ácidos nucléicos, bem como vetores de expressão de ácido nucléico e células hospedeiras contendo vetores de ácido nucléico são fornecidos. Além disso, composições contendo M. ..

Metacaspase II em engenharia de soja para resistência a doenças

A presente invenção está no campo da genética de soja. Mais especificamente, a invenção se refere a moléculas de ácido nucléico de regiões do genoma da soja, que estão associados com Phytoph de soja ..

USO DE RPA4 E RPA4/RPA32 polipeptídeos HYBRID para a proliferação celular MODULANTE

Divulgados são polinucleotídeos e polipeptídeos que são úteis para modular a proliferação celular. Os polinucleotídeos pode incluir regiões codificantes de RP A4 e RPA4/RPA32 polipeptídeos híbridos. O poli ..

COMPOSIÇÕES imunogênica para ATIVANDO? CÉLULAS T d

Divulgadas são composições, kits e métodos para a ativação, expansão, ou estimulante? Células T d que incluem recombinante micróbios atenuados. As composições podem incluir composição farmacêutica ..

Dedo de zinco nuclease para o gene CFTR E SEUS MÉTODOS DE USO

A presente invenção fornece proteínas de zinco e zinco nova dedo dedo nuclease (ZFNs) que encontrar em particular usando a reparar os fibrose cística reguladora da condutância transmembrana (CFTR) gene.

Oxidação direta de cálcio / calmodulina dependente da proteína quinase II e Associated Métodos de Diagnóstico e Terapêutica

Cálcio / calmodulina dependente da proteína quinase II (CaMKII) foi encontrado para ser diretamente oxidada e oxidação direta de CaMKII foi observada a resultar em cálcio ativação, independente de CaMKII. Antib ..

Ácidos nucléicos imunoestimulador

A invenção refere-se a composições immunostimulatory ácido nucléico e métodos de usar as composições. Os ácidos nucléicos ricos em T contêm seqüências poli T e / ou têm mais de 25% T nucleotídeo ..

VARIANT Ácido Nucleico TLR4 E USOS DOS MESMOS

A invenção fornece métodos para identificar polimorfismos no locus TLR4 humano, bem como métodos para identificar indivíduos em risco de indícios que aumentam a sua morbidade e mortalidade.

Transferases PROTEÍNA HUMANA Acil E MÉTODOS DE USO ESSE

A presente invenção proporciona a identificação dos humano Ras palmitoyl complexos acil transfersase, e ácidos nucléicos codificando os mesmos. Além disso, os métodos de triagem para moduladores de Ras p. humana.

SCHWEINFURTHINS E USOS DOS MESMOS

É descrito um método para prevenir ou tratar uma condição indesejável em um assunto transportando células nulas homozigotos para o tipo de neurofibromatose um gene ou assuntos que são haploinsufficient para t..

Baculovírus COM PRODUÇÃO virion reforçada e um método para a produção de baculovírus

Um método de co-expressando uma parte do gene da proteína VSV G ou um truncado "tronco" parte com um retrovírus GP64 e aumenta a título de vetores retrovirais. A VSV truncada da proteína G, de preferência ..

Longa ação peptídeo natriurético atrial (LA-ANP) E MÉTODOS PARA USO DO MESMO

Materiais e métodos relacionados à fabricação e uso polipeptídeos natriurético ter uma mutação que resulta em um terminal carboxi estendida.

COMBINAÇÃO MOTIF IMUNE oligonucleotídeos estimulante COM ATIVIDADE MELHORADO

Uma classe de ácidos nucléicos immunostimulatory tendo pelo menos dois domínios funcional e estruturalmente definido é fornecido. Esta classe de ácidos nucléicos combinação motivo imunoestimulador ativa um i..

Imunoestimulador moléculas de ácido nucléico

Sequências de ácidos nucleicos contendo dinucleotídeos CpG não metilado que modulam a resposta imune, incluindo estimulando um padrão Th1 de ativação imune, produção de citocinas, atividade NK líticas, e ..

RNA de interferência de supressão de doenças neurodegenerativas e MÉTODOS DE USO DOS MESMOS

A presente invenção é dirigida a pequenas moléculas de RNA de interferência (siRNA) dirigidas contra seqüência de ácido nucléico que codifica huntingtina ou ataxina-1, e métodos de usar essas moléculas de siRNA.

Oligonucleotídeos imunomoduladores

Oligonucleotídeos contendo dinucleotídeos CpG unthylated e utilidades terapêuticas com base em sua capacidade de estimular uma resposta imune em um indivíduo são divulgados. Também são terapias para t..

ANÁLOGOS SCHWEINFURTHIN

A invenção fornece análogos schweinfurthin fluorescente da fórmula (I) que são úteis como sondas e para o tratamento de câncer e outras doenças.

Fosforilada RECOMBINANTE N-acetil-alfa-D-glicosaminidase (NaGlu) e usa DELE

A presente invenção refere geralmente a proteínas de fusão recombinantes fosforilada NaGIu, a produção de proteínas de fusão recombinantes fosforilada NaGIu e usa do mesmo.

COMPOSIÇÕES E MÉTODOS PARA AUMENTAR A RESISTÊNCIA À DOENÇA EM PLANTAS

Composições e métodos para melhorar a resistência a doenças em plantas por níveis de modulação ou atividades de GmUBox1 polinucleotídeos e polipeptídeos são fornecidos. Plantas transformadas, células de plantas, tecidos ..

ATIVAÇÃO DE GLÚTEN DE MILHO DE ALTA PROTEÍNA POR MODIFICAÇÃO PH

Composições e métodos para inibir as plantas indesejáveis.

Diterpeno MODULADOR DE MATURAÇÃO MACRÓFAGO PHAGOSOMAL

Novos usos para moduladores diterpeno de maturação phagosomal macrófagos são fornecidos. O isotuberculosinol diterpeno é usado como um modulador imune, ensaio para composições farmacêuticas e um isola ..

Quiméricos DNA clones infecciosos, circoviruses suína quimérico e uso.

Una Molecula de Ácido nucleico quimérico de circovírus porcino infecciosa (PCV1-2) caracterizada tener una Por Molecula de Ácido nucleico Que codi un PCV1 infeccioso, sem patógeno Que contien ..

RAMAN-ACTIVE REAGENTES E DO USO DO MESMO

A presente invenção proporciona uma nova classe de Raman-ativa reagentes para uso em aplicações biológicas e outras, bem como métodos e kits para seu uso e fabricação. Cada reagente inclui uma Ram ..

Quimérico INFECCIOSAS CLONES DE DNA circovírus suíno E USOS DOS MESMOS

A presente invenção refere-se a DNA clones infecciosos, clones infecciosos DNA quimérico de circovírus suíno (PCV), vacinas e meios de protecção dos suínos contra a infecção viral ou pós-desmame MULTISY ..

Universal e diferencial ensaio sorológico para o vírus da gripe suína

Um kit de ensaio universal e diferencial para a detecção de anticorpos contra o vírus da influenza suína (SIV) em uma amostra biológica compreendendo SIV não-estrutural 1 (NS1) e proteína SIV nucleoproteína (NP); a..

Peptídeo de fusão compreendendo um novo acoplamento de um domínio com o silenciamento aptamer pequena molécula de peptídeo, é andrógeno inibidor do receptor, útil para tratar câncer de próstata e hiperplasia prostática benigna

Peptídeo de fusão (I) que compreende um acoplamento de um domínio com o silenciamento aptamer pequena molécula de peptídeo, para a inibição do receptor de andrógeno, é novo. - ATIVIDADE: citostáticos. - MECANISMO DE AÇÃO: An ..

Nematóide de cisto plantas transgênicas resistentes a

Composições e métodos para proporcionar resistência nematóide de cisto são fornecidos. Um aspecto fornece plantas transgênicas ou células compreendendo um ácido nucléico inibitório específico para um ou mais nematod cisto ..

SÍNTESE DESIGN, E FUNCIONAL DE CARACTERIZAÇÃO ROTTLERIN análogos

Um método de síntese de análogos rottlerin é descrito. Os métodos de síntese descritos são o primeiro método conhecido de sintetizar análogos de rottlerin comercialmente disponíveis materiais para produzir c..

Uso de methanobactin

A invenção fornece composições compreendendo e métodos que empregam methanobactin, bem como sequências sintetase methanobactin.

Células de rim tronco derivadas E MÉTODOS PARA SUA DIFERENCIAÇÃO DE ISOLAMENTO, E USO

A invenção refere-se geralmente a métodos para isolamento e cultura de células de rim-tronco, células isoladas pelos métodos e usos terapêuticos para essas células.

CÉLULAS-TRONCO adultas multipotentes E MÉTODOS PARA ISOLAMENTO

A invenção fornece células-tronco isoladas de não-embrionárias de origem que podem ser mantidas em cultura no estado indiferenciado ou diferenciado para formar células de vários tipos de tecido. Também provid ..

Análise dos padrões cerebrais usando medidas temporais

Um conjunto de dados do cérebro que representam uma série de tempo de atividade neurofisiológica adquiridos por sensores dispostos espacialmente distribuídos para detectar sinalização neural do cérebro (como pelo uso de magnetoencep ..

Aptâmeros DNA

A presente invenção refere ao diagnóstico rápido de contaminação por Salmonella usando aptâmeros DNA.

Biorreator High Throughput

Um sistema de biorreator de fluxo contínuo que inclui um biorreator, uma câmara de preparação opcional pós biorreator, um classificador de célula, e uma câmara de preparação opcional de pré-biorreator em um circuito fechado, use ..

Inibidores seletivos da QUINASES N-TERMINAL C-JUN

Composições e métodos para tratar, prevenir ou melhorar um ou mais sintomas, distúrbios ou condições associadas com especial c-Jun N-terminal quinase (s) (JNKs) atividade são fornecidos. Co..

ANTI-flavivírus TERAPÊUTICO

A presente invenção refere-se a anti-flavivírus compostos, incluindo lycorine e seus derivados, e seu uso no tratamento de um sujeito infectado por um flavivirus. A presente invenção também se refere ..

Recombinação homóloga em células progenitoras adultas multipotentes

A invenção refere-se a métodos de alterar a expressão gênica por recombinação homóloga em uma célula progenitora adultas multipotentes (CMAP). Em particular, métodos de produção de um MAPC recombinante, de corre ..

EXPANSÃO-ASSOCIADOS REPEAT NUCLEOTÍDEO polipeptídeos E USOS DOS MESMOS

Polipeptídeos isolados que são endogenamente expressa das expansões de repetição de nucleotídeos são divulgados. Em alguns casos, incluem os polipeptídeos repete polipeptídeo. Em alguns casos, a REPEA polipeptídeo ..

Neurotrofinas E USOS DOS MESMOS

A neurotrofina polipeptídeo, e um seu fragmento biologicamente ativo, são descritos. Além disso, os métodos são revelados, que incluem o fornecimento de uma composição que compreende a neurotrofina polipeptídeo para um sub ..

MODIFICAÇÃO DNA TAL efetoras-MEDIADA

Materiais e métodos relacionados a gene targeting (por exemplo, com a transcrição do gene alvo ativador-como nucleases efetoras, "Talens") são fornecidos.

INFLAMAÇÃO REDUÇÃO meio da terapia celular

A invenção fornece métodos para o tratamento de condições patológicas associadas com um componente indesejável inflamatórias, incluindo a do enxerto-versus-hospedeiro da doença. A invenção geralmente é direcionada para ..

Polipeptídeos Haemophilus parasuis e métodos de uso

A presente invenção fornece polipeptídeos isolados tendo atividade permease oligopeptídeos e uma seqüência de aminoácidos que tem pelo menos 80% de identidade com um polipeptídeo Haemophilus parasuis Oppa. Também ..

Decelularização E RECELLULARIZATION APARELHOS E SISTEMAS QUE CONTÉM O MESMO

A invenção aqui descrito fornece sistemas e aparelhos para um initialpreparation de um órgão ou tecido de andaime compreendendo uma matriz extracelular, e recellularization subseqüente do sca ..

TRATAMENTO DE DOENÇAS CAUSADAS POR BACTÉRIAS exotoxinas

Fornecidos são de alta afinidade do receptor de células T regiões variáveis que são úteis para tratar doenças causadas por superantígenos incluindo dermatite atópica, pneumonia e cicatrização retardada. A variável ..

Detecção de diferenças seqüência de ácido nucléico e usando a reação de detecção ligase com arrays endereçável

A presente invenção descreve um método para identificar um ou mais de uma pluralidade de seqüências diferentes por uma ou mais mudanças de base única, inserções, exclusões ou translocações em uma pluralidade o..

GERAÇÃO MAPC do tecido pulmonar

A presente invenção refere-se a métodos de melhorar a função no tecido pulmonar através da administração de uma população de células progenitoras adultas multipotentes ("MAPCs") ou progênie diferenciada do mesmo.

MODIFICADOS vitamina K-dependente polipeptídeos

A invenção fornece vitamina K-dependente polipeptídeos com afinidade de ligação da membrana reforçada. Estes polipeptídeos podem ser usados para modular a formação de coágulos em mamíferos. Métodos de coágulo formato de modulação ..

Stem Cell e Agregados métodos para fazer e usar

A invenção é direcionada a composições de agregados celulares e métodos para fabricar e usar os agregados celulares, onde os agregados compõem as células que não são células embrionárias popa, mas pode difere ..

MODIFICADOS vitamina K-dependente polipeptídeos

Marcadores moleculares para Identificação de fenótipos gorda e magra EM GALINHAS

A invenção fornece métodos moleculares de frangos de triagem para determinar aqueles mais propensos a ter um fenótipo magra ou gorda, identificando a presença de pelo menos um polimorfismo genético no materi ..

Hidrogéis NOVEL E USOS DOS MESMOS

A presente invenção proporciona novos hidrogéis e métodos de fazer e usar tais hidrogéis. A presente invenção proporciona hidrogéis que podem ser formadas pela auto-montagem de peptídeos em solução ...

Hidrogel PEPTIDE INJETÁVEL BETA-hairpin QUE MATA meticilina aureus resistente à meticilina

Um peptídeo compreendendo a seqüência VKVKVRVKVDPPTKVKVRVKV-NH2 forma um hidrogel que tem a capacidade de corte fino e recuperar. O hidrogel, antes e depois corte fino, é capaz de matar ..

Identificação de fenótipos gorda e magra Em Frangos utilizando marcadores moleculares

A presente invenção fornece métodos de frangos de triagem para determinar aqueles mais propensos a ter um fenótipo magra ou gorda. A invenção também fornece métodos de frangos de triagem para identificar uma pol ..

ENTREGA DE hidrogéis como sprays

Um método para a entrega de hidrogéis folha-beta peptide a uma superfície-alvo, corte fino e borrifar o hidrogel peptídeo na superfície é fornecida. Os hidrogéis beta folhas peptídeo pode ser aplicada ..

FERTILIDADE REFORÇO DE USAR carreadores lipídicos e moléculas bioativas

A invenção refere-se a uma composição e método para aumentar a fertilização.Aprimoramento de fertilização é obtida através de uma eficaz entregar moléculas bioativas com uma âncora de lipídios (GPI-linked prote ..

Fragmentos Perlecan como Biomarcadores de Lise Estroma óssea

Um método para a detecção de um fluido corporal de perlecan fragmentos de polipeptídeos que são biomarcadores de metástase do tumor, e anticorpos para detectar estes fragmentos são descritos. Um kit de imunoensaio para ..

DIFFUSION MACROMOLECULAR e libertação da auto-montagem hidrogéis B hairpin peptídeo

Um hidrogel para a liberação tardia de uma macromolécula aniônico, onde o hidrogel compreende a macromolécula aniônicos, 150 mM NaCl, e um peptídeo selecionado do grupo consistindo de SEQ ID NO: 1 throu ..

MÉTODOS E COMPOSIÇÕES PARA O DISPLAY de polipeptídeos NO PILI DE Bactérias Gram-Positivas

Fornecidos aqui métodos e composições para a exibição de polipeptídeos de interesse na ponta da pili de bactérias Gram-positivas. De acordo com a presente invenção, o polipeptídeo de i. interesse.

COATED QUANTUM DOTS E MÉTODOS DE FAZER E USAR MESMO

A divulgação atual fornece encarnações de uma nova classe de pontos hidroxilados quântica. Os pontos quânticos têm um casaco nela hidroxilados eliminados, e que serve para minimizar não-específicas celular ..

COMPOSIÇÕES imunogênica E MÉTODOS DE USO DOS MESMOS

Manifestações da divulgação abranger composições e métodos para gerar respostas imunes em um animal hospedeiro humano ou Manifestações das composições abrangem proteínas derivadas da superfície ..

Composições e métodos para gerar uma resposta imune

Nós desenvolvemos e DNA viral vetores que podem ser utilizados, isoladamente ou em combinação, como uma vacina contra uma cepa do HIV, subtipo, ou forma recombinante do HIV ou contra múltiplos subtipos do HIV, subtipos, ou ..

MODULAÇÃO DE CANAIS DE SÓDIO POR nicotinamida adenina dinucleotídeo

A presente invenção refere-se ao uso de oxidado nicotinamida adenina dinucleotídeo (NAD +) ou de sua forma reduzida, NADH, como moduladores dos canais de sódio. A presente invenção também se relaciona com o uso ..

MÉTODOS DE USAR produção de anticorpos monoclonais FUSION peptídeo-TRANSFERÊNCIA epítopo adotivos (F-PEAT) TECNOLOGIA

São divulgadas composições e métodos para relacionadas com anticorpos monoclonais específicos para a variação de um único aminoácido em um antígeno.

MÉTODOS PARA DETERMINAÇÃO DA ACTIVIDADE proteína fosfatase, e utiliza na previsão de consequências TERAPÊUTICO

Um aspecto da presente divulgação inclui métodos para determinação de uma proteína quinase ou atividade da fosfatase em uma amostra biológica, compreendendo: contatar em uma reação de uma mistura a. primeira amostra de teste.

BHC80 - COMPLEXOS histona e usos deles

Aqui previsto é a estrutura terciária de domínios da proteína BHC80, incluindo o domínio dedo PHD, como quando a proteína BHC80 é complexado com uma cauda sem modificações das histonas H3 na apresentação ..

Re-engenharia DANO endonuclease UV, composições e métodos

Fornecidos são métodos e composições para reduzir os danos causados à pele pela luz ultravioleta e outros agentes que causam distorção de DNA de fita dupla e métodos para reduzir danos a outros órgãos devido ..

PEPTÍDEO KETOAMIDES HETEROCÍCLICOS

Uma nova classe de peptídeos a-ketoamides útil para inibir seletivamente calpains, proteases cisteína seletivamente inibir, e geralmente inibindo todas as proteases de cisteína, tendo a fórmula M-AA2-A ..

PH-dependente antagonistas dos receptores NMDA

Bloqueadores dos receptores NMDA, incluindo pH-sensíveis bloqueadores dos receptores NMDA, são fornecidos como drogas neurprotective que são úteis em curso lesão cerebral traumática, epilepsia e outros eventos neurológicos tha ..

Agentes de imagem

Esta invenção fornece derivados do ácido amino útil na detecção e avaliação de tumores cerebrais e do corpo, incluindo (1S, 2S) anti-2-[18F] FACPC e (1R, 2R) anti-2-[18F] FACPC.

ALZHEIMER DOENÇA DE AGENTES DE IMAGEM

Esta invenção fornece compostos e métodos de depósitos de amilóide imagem usando compostos radioativos. Esta invenção também fornece um método de inibir a agregação de proteínas amilóides para formar ..

USO DE RANKL Para induzir diferenciação de células MICROFOLD (células M)

A diferenciação de microfold (M) células é importante para a imunidade da mucosa. A diferenciação das células M é desejável, como em situações em que uma resposta do hospedeiro a um antígeno é sub-ótima, o..

PURINA NUCLEOSÍDEO Prodrogas MonoPhosphate para tratamento de câncer e infecções virais

A presente invenção é dirigida a compostos, composições e métodos para tratar ou prevenir câncer e infecções virais, em particular, HIV, HCV, norovírus, Saporo vírus, o HSV-I, HSV-2, Dengue ..

9-AMINONOSCAPINE E SEU USO EM TRATAMENTO CÂNCER, INCLUINDO resistentes a drogas CÂNCERES

9-aminonoscapine, pró-fármacos dos mesmos, e sais farmaceuticamente aceitável, são divulgados. Composições farmacêuticas incluindo 9-aminonoscapine, e métodos de preparação e uso são ..

Aminoquinoleína DERIVADOS proteína de choque térmico 90 INIBIDORES, métodos de preparação MESMO, E MÉTODOS PARA SUA UTILIZAÇÃO

Novos tipos de chaperone molecular proteína de choque térmico 90 (Hsp90) inibidores e métodos para fazer essas classes são fornecidas aqui. Estes compostos são úteis no tratamento e prevenção do câncer e ..

Proteína de choque térmico 90 INIBIDORES, métodos de preparação MESMO, E MÉTODOS PARA SUA UTILIZAÇÃO

Novos tipos de chaperone molecular proteína de choque térmico 90 (Hsp90) inibidores são divulgados. Estes compostos são úteis no tratamento e prevenção do câncer e outras doenças relacionadas com Hsp90 e condição ..

BIOMARCADORES CÂNCER DE PRÓSTATA em predizer recorrência e potencial metastático

Aqui descritos são métodos para prever a recorrência, progressão e potencial metastático de um câncer de próstata em um assunto. Por exemplo, o método compreende a detecção de uma amostra de uma subj ..

Análogos TRIARYLMETHANE e sua utilização no tratamento de câncer

Compostos, composições farmacêuticas incluindo os compostos, e métodos de preparação e ao seu uso são divulgados. Os compostos são análogos trifenil metano. Os compostos e composições ca ..

Inibidores de enzimas NOX E MÉTODOS DE USO DOS MESMOS

Inibidores de enzimas Nox, como Noxl, NOX2 e NOX3, e métodos de fazer e usar tais compostos são descrever aqui.

Uso de inibidores de mTOR para melhorar as respostas das células T imunes

É divulgado aqui que o tratamento de um sujeito com um inibidor de mTOR aumenta antígeno-específicos respostas de células T imunes. Assim, aqui fornecido é um método de aumentar a um antígeno específico da célula T r..

HUMANA ANTI-PD-1, PD-L1, L2 E PD-ANTICORPOS E USOS ESSE

A presente invenção é baseada, em parte, na identificação de novos humana anti-PD-1, PD-L1, L2 e PD-anticorpos. Assim, a invenção refere-se a composições e métodos para o diagnóstico, pro ..

IMUNOTERAPIA resistente a medicamentos para tratamento de uma CÂNCER

A divulgação atual está geralmente relacionada a métodos para a combinação de quimioterapia e imunoterapia para o tratamento de um câncer. Os métodos também se relacionam para gerar uma imunização resistentes aos medicamentos citotóxicos ..

TUMOR COMPOSTOS IMAGING

A invenção fornece novos compostos de aminoácidos de uso na detecção e avaliação de tumores cerebrais e do corpo. Estes compostos combinam as propriedades vantajosas do ácido alfa-aminoisobutyric anal (AIB) ..

Obter respostas imune usando vírus recombinantes MVA EXPRESSANDO HIV ENV, GAG E ANITGENS POL

Métodos para eliciar benéfica respostas imunes contra o HIV através da administração a um sujeito um vírus MVA recombinantes expressando HIV env, gag, pol e antígenos são descritos. O MVA recombinante é admi ..

GAMBOGIC AMINE, um agonista TRKA SELETIVA COM ATIVIDADE neuroprotetor

Agonistas de molécula pequena, agonistas parciais e antagonistas para o receptor TRKA são descritos. Os compostos são aminas gambogic, onde o grupo ácido carboxílico de gambogic ácido (CO2H) foi repl ..

Avaliação da resposta do tumor a TERAPIA

Sistemas, métodos e produtos programa de computador identificar os dados biológicos primeiro de uma região de interesse em uma primeira imagem e calcular um histograma primeiro volume biológicos a partir dos dados biológicos em primeiro lugar. Secon ..

DWF4 Polinucleotídeos, Polipeptídeos e usos deles

A presente invenção refere-se a novela, polinucleotídeos isolados de plantas anãs.O dwf4 polinucleotídeos que codificam a totalidade ou uma parcela de, um DWF4 polipeptídicas, uma enzima citocromo P450 que medeiam ..

Imobilizando Uma entidade em uma orientação desejada EM UM MATERIAL DE APOIO

A presente invenção refere-se à identificação e seleção de moléculas que se ligam apego / imobilizar uma entidade com uma actividade detectável ou propriedade sobre um suporte em uma orientação que ..

BACTÉRIA RECOMBINANTE capazes de induzir uma resposta imune contra Streptococcus pneumoniae

A invenção abrange uma bactéria recombinante capaz de induzir uma resposta imune contra o Streptococcus pneumoniae, uma vacina compreendendo a bactéria, e métodos de usar a bactéria.

Anticorpos sintéticos

A presente invenção fornece métodos para detecção de anticorpos sintéticos, métodos para produção de anticorpos sintéticos, métodos para a identificação de ligantes, e métodos relacionados e reagentes.

Lectina ARTIFICIAL E USOS DOS MESMOS imita

As lectinas são importante classe de proteínas de ligação de açúcar envolvidos em uma variedade de fenômenos biológicos. Em alguns aspectos, a presente invenção refere-se ao processo de seleção e aplicação de alta ..

CÂNCER DE PRÓSTATA MARCADORES E USOS DOS MESMOS

A presente invenção fornece métodos para avaliar a probabilidade de um tumor de próstata em um assunto, ou para o monitoramento da eficácia do tratamento para câncer de próstata, que envolve a detecção de QSOX1 em pati ..

PÂNCREAS MARCADORES CÂNCER E USOS DOS MESMOS

A presente invenção fornece métodos e reagentes para avaliar a probabilidade de um sujeito ter um tumor no pâncreas, e para a eficácia de monitorização de tratamentos para tumores pancreáticos.

Anticorpos sintéticos

Métodos para detecção de anticorpos sintéticos, métodos para produção de anticorpos sintéticos, métodos para a identificação de ligantes, e métodos relacionados e reagentes.

SYNBODIES TO AKT1

O presente pedido fornece synbodies contra AKT1 diferentes em seqüência de aminoácidos, química conjugação, linker / andaime, ou meação adjunto. O synbodies são úteis para o diagnóstico e treatmen ..

MÉTODOS DE AVALIAÇÃO A RISCO DE CÂNCER DE PROGRESSÃO

Métodos e kits que usar a expressão de miRNA para prever o desenvolvimento de metástases cerebrais em não-pequenas células doentes de câncer de pulmão são divulgados.

BACTÉRIA RECOMBINANTE Edwardsiella

A presente invenção engloba uma bactéria Edwardsiella recombinante, e composições e métodos de uso dos mesmos.

UM SISTEMA Replicon DNA de alto nível de produção rápida de vacinas e THERAPEUTICS ANTICORPO MONOCLONAL EM PLANTAS

Vetores planta viral têm grande potencial na produção rápida de proteínas, mas não simples Aqui um sistema baseado em geminivírus para a produção de alto rendimento e rápida de complexos de proteínas oligoméricas, inclusive v..

FILMES MOLECULAR PARA SUPERFÍCIES DE IMPLANTES HYDROPHOBIC

Composições são divulgados contendo um gel viscoelástico solvatados poliméricas diluídas em uma solução aquosa condutora ionicamente que podem ser proveitosamente aplicado a qualquer superfície que é hidrofóbico para ac ..

MÉTODOS PARA IDENTIFICAR RISCO DE CÂNCER

Contidas neste documento são regiões de tecidos específicos diferencial metilados (T-DMRS) e as regiões relacionadas ao câncer diferencial metilados (C-DMRS) e métodos de uso dos mesmos. Em uma modalidade da invenção, ..

Métodos de tratamento de sarampo doenças infecciosas em mamíferos

A invenção prevê uma vacina contra o sarampo utilizando um códon-otimizados humanos polinucleotídeo que codifica um polipeptídeo vírus do sarampo, como HA ou proteína F. Opcionalmente, a vacina é administrada sagacidade ..

Cardíaca Células-Tronco

Células-tronco cardíacas podem ser isoladas a partir de biópsias endomiocárdicas.Tais células mediar regeneração cardíaca e melhorar a função cardíaca em um modelo de infarto do mouse. As células podem ser usadas para autólogo ..

Análise integrada de mama e colorretal

Genome-wide análise das mudanças no número de cópias na mama e tumores colorectal utilizado abordagens que pode detectar deleções homozigóticas e amplificações. O número de genes alterados por cópia grandes ..

Bioluminescência ensaio de rastreio IMAGING BASEADA e inibidores de ABCG2

A bioluminescência de imagens baseado em ensaio de alto rendimento para os inibidores de ABCG2 é descrito. Composições de inibidores da ABCG2 e métodos de usar ABCG2 inibidores também são descritos.

DNA INTEGRIDADE DO ENSAIO (DIA) PARA DIAGNÓSTICO câncer, usando espectroscopia de fluorescência confocal

A presente invenção refere, por exemplo, a um método para determinar a distribuição do tamanho das moléculas de DNA em uma amostra de células livres de ácido nucléico, que compreende o DNA rotulagem com um dy fluorescentes ..

MÉTODOS PARA FREPARATION E USO DE LINFÓCITOS MEDULA infiltrando (MILS)

A invenção fornece composições compreendendo medula activado infiltração de linfócitos, os métodos de geração de populações de lymphcytes medula infiltrando, usa da medula lymphocyt infiltrando ..

STAT3 antagonistas e seus usos como vacinas contra o câncer

A presente invenção refere-se a métodos para tratar e / ou prevenção do câncer.Em particular, a presente invenção se refere a métodos ex vivo imunoterápicos. Os métodos compreendem diminuindo Stat3 ..

Métodos para identificar risco de câncer

A presente invenção fornece métodos e kits para a identificação de um risco aumentado de desenvolver câncer em um indivíduo. Os métodos incluem análise de uma primeira amostra biológica, como uma amostra de sangue, fr ..

Adesiva biopolímero Imidated e hidrogel

Polímeros biologicamente compatível transportar uma imida e pode ser usado como adesivo, um hidrogel ou ambos. Um segundo polímero reativo biologicamente compatível com o polímero imidated pode ser usado com o mesmo ..

Reagentes e Métodos para Envolver único Clonotypic receptores de linfócitos

latforms compreendendo pelo menos uma molécula de linfócitos que afetam e pelo menos um complexo molecular que, quando ligado a um antígeno, envolve um receptor de linfócitos única clonotypic pode ser usado para induzir ..

Linhas de transgênicos Frog e Ensaios empregá-los

Rodopsina transgenes impulsionada pelos promotores rodopsina foram produzidas, algumas seqüências ligado a GFP de codificação como uma fusão construir. Quando os transgenes resultantes foram introduzidos no Xenopus laevis, o ph ..

Microarrays de binário sondas de ácidos nucléicos PARA DETECTAR analitos de Ácido Nucleico

É descrito um microarray de binário sondas de ácidos nucléicos para a detecção de um ou uma pluralidade de analitos de ácido nucléico em uma amostra complexa em um ensaio de vazão única alta com extraordinária específica ..

Várias fases, biodegradável e osteointegrative andaime composto para fixação biológica do tecido mole do osso músculo-esqueléticas

Métodos e aparelhos são fornecidos para a engenharia de tecidos músculo-esqueléticos. Por exemplo, um aparelho de andaime é fornecido que compreende microesferas de tamanhos selecionados e / ou composição. Os micros ..

Uma enzima DNA SPLIT para digitação POLIMORFISMO VISUAL de nucleotídeo único

Uma sonda que muda de cor na solução a presença de apenas uma das duas seqüências de DNA, que diferem por um único nucleotídeo, é relatado. A sonda consiste em duas Oligodesoxirribonucleotídeos, que f..

VINCULADOS PEPTIDE biossensores Fluorogênico

Biossensores, biosensores composições compreendendo, métodos de produção de biossensores, e métodos de usar biossensores são divulgados. Os biossensores compreendem um peptídeo fluorogen de ativação e um p. bloqueio.

MUTANTES DA PROTEÍNA DE P4 Haemophilus influenzae não tipável com atividade enzimática REDUZIDO

Uma proteína variante P4 que reduziu a atividade enzimática e que induz anticorpos para o tipo selvagem proteína P4 e / ou tem atividade bactericida contra o bom não tipáveis H. influenzae (NTHi) é útil como a..

Estereoquimicamente DEFINIDO dipeptídeo ÉSTERES DE agentes antivirais para tratamento ocular ENHANCED

Estereoquimicamente definido ésteres dipeptídeo de nucleosídeo-análogo agentes antivirais incluindo o aciclovir e ganciclovir são fornecidos. Alguns desses ésteres estereoquimicamente definido dipeptídeo são fundações ..

PLANTA DE PLATAFORMAS cromossomo artificial VIA TRUNCAMENTO telômero.

A invenção fornece plantas de engenharia minichromosomes gerado pelo truncamento mediada telômeros de cromossomos nativa. Estes minichromosomes são fielmente transmitidos de uma geração para a nex ..

ACICLOVIR peptídeo análogos

Derivados de éster de dipeptídeo e tripeptídeo de aciclovir e seus análogos são divulgadas, que são úteis para tratar infecções de herpes vírus. Também é descrito um método para preparar um agente terapêutico para ..

Genes Responsive seca em plantas e métodos de seu uso

Microarrays são empregadas para analisar transcrições de soja sob condições de estresse hídrico em ambos os tecidos da raiz e folhas na fase vegetativa. Novos genes responsivos à seca podem ser assim identificados e ma ..

CAFFOLD para o osso e reparar o tecido EM MAMÍFEROS

Um tecido de mamíferos andaime e método para fazer um tecido scaffold incluindo um corpo de andaime rígida de fibra de vidro biocompatível unidos e em alinhamento especial para definir canais abertos withi ..

Método para a detecção de metilação do DNA em células de câncer

A presente invenção proporciona um método de detecção de detecção de células malignas em amostras de um paciente ou uma amostra biológica. Especificamente, o método inventivo inclui as etapas de extração de um gen ..

ENSAIOS PARA DETECÇÃO DE GRAVIDEZ ASSOCIADAS Glicoproteínas

São divulgados métodos e composições para a detecção de gravidez em um animal, por meio de dosagem de atividade de peptidase de um ou mais Glicoproteínas Associated Gravidez (PAGs). Em certos aspectos, o método ..

Seleção Phage Display de Peptídeos Anti Fungal

Um método para a identificação de peptídeos tendo uma afinidade para a superfície de fungos é fornecido como um método para a identificação de peptídeos capazes de afetar o desenvolvimento de um fungo. ..

INIBIDORES NOVEL da transcriptase reversa RETROVIRAL

São divulgadas moléculas de ácido nucléico e métodos de seu uso, que têm uma estrutura específica, incluindo um domínio de dupla hélice e um domínio G-quadruplex fisicamente conectados por um domínio que linker ..

Modulando os níveis de RNA-proteínas de ligação para o tratamento de câncer de mama

A presente invenção refere-se a métodos de usar RNA-binding protein agentes de modulação para tratar de câncer, principalmente pacientes que são suscetíveis a ou b. diagnosticado com receptor de estrogênio negativo.

Auto-montagem de corpos multicelulares e métodos de produção A estrutura tridimensional BIOLÓGICA usando o mesmo

Estruturas e métodos de engenharia de tecidos inclui um corpo multicelular, incluindo uma pluralidade de células vivas. Uma pluralidade de corpos multicelulares podem ser dispostos em um padrão e permitiu a fusão t..

ANDAIMES COM OLIGOELEMENTO PARA REGENERAÇÃO DE TECIDOS DE MAMÍFEROS

Um andaime para implantação em um mamífero para facilitar o crescimento navio em reparo, regeneração e / ou proliferação de tecidos corporais, onde o andaime é baseado em um borato, silicato ou fosfato, g..

O crescimento dos vasos e direcionalidade CONTROLE EM MAMÍFEROS E MATERIAL Implantável

Um método para direcionar o crescimento dos vasos em direção a um site de sangue deficiente em um mamífero compreendendo implantação no mamífero em um conjunto de fibras de vidro para formar uma ponte vascular com uma primeira extremidade do va ..

ANDAIME PARA REGENERAÇÃO DE TECIDOS DE MAMÍFEROS

Um andaime tridimensional com poros interconectados para o reparo de tecido que compreende um corpo de andaime para o apoio estrutural do tecido andaime, onde o corpo de andaime compreende scaffold co corpo ..

MÉTODO PARA DESENVOLVER ALTA SOJA ácido oléico USAR técnicas convencionais de cruzamento SOJA

Divulgada é uma planta de soja com mutações no FAD2-1A e 1B FAD2. Além disso, a divulgação é direcionada para as sementes de plantas, disse com relações alteradas de gorduras monoinsaturadas e poliinsaturadas Em particul ..

SOJA fatores de transcrição e outros genes e MÉTODOS DE SEU USO

Expressão do gene é controlada no nível transcricional pelo grupo muito diverso de proteínas chamadas fatores de transcrição (TF). 5671 de soja (Glycine max) genes foram identificados e divulgada como ..

AUTISMO-ASSOCIADOS BIOMARCADORES E USOS DOS MESMOS

Biomarcadores para o autismo humanos são divulgados. Métodos para tratar, prevenir e diagnosticar o autismo humana e perturbações relacionadas com autismo também são divulgados.

USOS DE ANDAIME imunologicamente MODIFICADOS PARA TRANSPLANTE DE CÉLULAS DO TECIDO PREVASCULARIZATION

Esta invenção proporciona um método de fabricação e uso de uma porosa três dimensões cíclicas RGD-peptídeo modificado alginato andaime que pode ser carregado com diferentes tipos de células e / ou fatores de crescimento para a implan ..

Degradação enzimática da A2E e outros compostos BISRETINOID DE RPE lipofuscina

A presente invenção fornece métodos para reduzir a quantidade de lipofuscina compostos presentes em uma célula que compreende contatar a célula com uma quantidade de uma enzima suficiente para, direta ou indir ..

RECOMBINANTE HUMANA FOLÍCULO ESTIMULANTE ANTAGONISTAS HORMONAIS E MÉTODOS DE USO

Em uma modalidade da presente invenção é dirigida a um hormônio folículo estimulante humana recombinante (FSH) ter reduzido antagonista N-linked glicosilação. Em outras modalidades, o presente inventar ..

COMPOSIÇÕES DE PROTEÍNAS NOTCH humanizado FUSION e métodos de tratamento.

Esta invenção fornece uma proteína de fusão compreendendo um peptídeo sinal, um domínio extracelular do receptor Notch proteína humana e uma porção Fc de um anticorpo a elas vinculados. Esta invenção também provid ..

SISTEMAS E MÉTODOS para induzir PULSOS campo elétrico em um órgão do corpo

Sistemas e métodos para fornecer estimulação parâmetro controlável pulso magnético são descritas. Um aspecto é direcionado para um sistema de estimulação magnética para induzir electr aproximadamente rectangular ..

MÉTODOS PARA TRANSPLANTE indução de tolerância

Um método é fornecido para a prevenção da rejeição de um sistema imunológico de um sujeito destinatário de um tecido transplantado de um doador assunto sobre o assunto destinatário sem a necessidade de longo prazo adminis ..

GAB2 AMPLIAÇÃO EM MELANOMA

Fornecidos aqui métodos de detecção ou inibição do crescimento de melanoma com base em Gab2 expressão da proteína. Gab2 proteína foi encontrada para ser amplificado e / ou overexpressed em melanoma. Gab2 ex proteína ..

HERPES VIRUS PARA BACKBONE VACINA VIRAL E NELE vacina baseada

Um ácido desoxirribonucléico recombinante compreendendo um vírus simples do herpes humano (HSV) ácido desoxirribonucléico (DNA) com um DNA heteróloga integrado nele onde o DNA heteróloga codifica uma polype ..

IMPLANTES osteocondral, MÉTODOS ARTROPLASTIA, dispositivos e sistemas

Implantes para resurfacing ou reparar uma ou mais superfícies articulares da cartilagem de apoio de um organismo biológico incluem uma engenharia de tecidos e um substrato biocompatível poroso preso à engenharia de ..

Fibroblastos tronco derivadas

A presente invenção fornece métodos e composições relacionadas à produção de células-tronco, derivadas de fibroblastos indiferenciado, eo uso de tais células-tronco para tratamento de uma variedade o..

Método paralelo massivo para decodificação de DNA e RNA

Esta invenção fornece métodos para a fixação de um ácido nucléico para uma superfície sólida e para o seqüenciamento de ácidos nucléicos, detectando a identidade de cada nucleotídeo analógico após o análogo de nucleotídeo é i..

SISTEMAS E MÉTODOS DE SANGUE BASEADO EM TERAPIAS TENDO UM DISPOSITIVO DE CÂMBIO microfluídicos MEMBRANELESS

A presente invenção é dirigida a dispositivos, sistemas e métodos para remover materiais indesejáveis de um fluido de amostra pelo contato com um fluido segundo.O fluido da amostra flui como uma fina camada adjacente ..

ENSAIO PARA A DETERMINAÇÃO DE SAÚDE DE CÉLULAS T CD8 +

Um método de determinar se um sujeito CD8 + células-T funcionalmente reconhecer uma estrutura alvo HLA-E/Hsp60sp comppsmg a) entrar em contato com uma amostra do sujeito CD8 + células-T com um HLA-E wit + celular carregado ..

DISPOSITIVOS microbolhas, MÉTODOS E SISTEMAS

Um hidrogel de engenharia de tecidos scaffold ter microbolhas dispersas nele é divulgada. Além disso, um sistema de cultura de células, incluindo um controlador e atuador para aplicar carga de deformação dinâmica ..

SITE ligação do ligando do RAGE E USOS DOS MESMOS

O presente método prevê um peptídeo isolado tendo uma seqüência de aminoácidos correspondentes à seqüência de aminoácidos de uma V-domínio de um receptor para o produto final da glicação avançada (RAGE). O pr ..

MÉTODOS PERFIL UNIVERSAL metilação

Esta invenção fornece métodos de derivatizing um DNA double-stranded compreendendo contato com double-stranded DNA com um apagar methyltransf CpG e um analógico s-adenosilmetionina. Esta invenção também pr ..

Entrega de DNA ou RNA Via Junções Gap de células hospedeiras para células-alvo e um sistema de fornecimento baseados em células para Antisense ou siRNA

Um método de entrega de um oligonucleotídeo ou a um plasmídeo expressando um oligonucleotídeo em uma célula-alvo compreende a introdução de um oligonucleotídeo em uma célula doadora, particularmente uma célula-tronco, e contac ..

CÂNCER CÉLULAS-TRONCO, KITS, E MÉTODOS

A presente invenção fornece uma célula-tronco de câncer que tem, inter alia, as propriedades da divisão celular assimétrica, a capacidade de iniciar tumor, e competência metastático. Este cancro população de células-tronco ..

Camundongos transgênicos sobre-expressando receptor para produto final glicação avançada (RAGE) no cérebro e usa do mesmo

A presente invenção prevê um animal não-humano transgênico, cujas células contêm uma seqüência de DNA que compreende: (a) um promotor tecido nervoso específico, e (b) uma seqüência de DNA que codifica um receptor para ..

CONTROLE DE germinação de esporos

Fornecido é um método de germinação estimulante de um esporo de uma bactéria Gram-positivas. Também é fornecido um método de inibição da germinação de um esporo de uma bactéria Gram-positivas. Além disso provi ..

COMPENSADORES para bloqueio atrioventricular USAR um ácido nucléico ENCODING um canal de sódio ou proteína GAP JUNCTION

Um método de aumentar a velocidade de condução AV em um mamífero que pode ser no bloco de coração ou em risco de bloqueio cardíaco, fazendo com que, em um nó AV e / ou His com menos de spe condução normal ..

Método para doseamento de interação proteína-proteína

A invenção se refere a um método para determinar se um composto de teste, ou uma mistura de compostos, modula a interação entre duas proteínas de interesse.A determinação é possível através do uso ..

Métodos para prever o resultado da gravidez em um assunto por ensaio HCG

A presente invenção fornece um método de predizer o resultado da gravidez em um assunto por determinação do montante de uma gravidez precoce associada isoforma molecular de hCG em uma amostra. O presente inventar ..

Histona acetiltransferase ACTIVADORES E USOS DOS MESMOS

A invenção fornece um método de triagem de compostos que se ligam e modulam uma proteína histona acetiltransferase. A invenção ainda fornece métodos para o tratamento disorde neurodegenerativas ..

Ácidos nucléicos para a expressão da proteína inibindo hairless e métodos de utilização do mesmo

A presente invenção proporciona DNAzymes ribozimas e que, especificamente, deixar mRNA Protein calvo. A presente invenção também fornece oligonucleotídeos antisense que inibem especificamente translatio ..

Biorreator, dispositivos, sistemas e métodos

Divulgados são biorreator dispositivos, sistemas e métodos. Um sistema de biorreator pode incluir um ou mais módulos de biorreator que pode ser controlado individualmente e identificável. Um módulo de biorreator pode ser ..

SISTEMAS E MÉTODOS DE SANGUE BASEADO EM TERAPIAS TENDO UM DISPOSITIVO DE CÂMBIO microfluídicos MEMBRANELESS

Implantes médicos, PRÓTESES, PEÇAS E PRÓTESES, INSTRUMENTOS MÉDICO, dispositivos e invenções AUXILIAR feito de uma substância MAGNÉSIO HALOGENIDE-MODIFIED

O uso de uma substância de magnésio, cuja corrosividade é alterado como resultado da modificação com ehalogéneo, permite implantes médicos, próteses ou partes próteses e instrumentos médicos, equipamentos ..

SUBSTRATOS fluorogênico para fosfatases PROTEÍNA E ENSAIOS DE INCORPORAÇÃO os substratos

Fornecidas são uma classe de substratos da fosfatase fluorogênico proteína. Estes substratos fluorogênico compreende uma porção de carbamato tendo um grupo carbamato funcional diferente do hidrogênio ligado ao carba ..

Potencialização longo-tempo cíclico-GLUR6 análogos

Esta invenção revela CN2097-like composições que facilitam a indução de potenciação de longa duração (LTP). Em uma modalidade do método compreende induzindo potenciação de longa duração em um assunto por ..

INTEIN BASEADA FLUORESCENT BIO CIRCUITO PARA DETECÇÃO DE VITAMINA D

Esta invenção é direcionada a um intein biosensor baseado em vitamina D fluorescentes que com precisão e rapidez as medidas la ,25-hidroxivitamina D3.Medição em quantidades picomolar é anotado. Ref especial ..

DETECÇÃO DE curtas seqüências de RNA

Um ensaio para a detecção de seqüências curtas de RNA em uma amostra sintética ou clinicamente isoladas é aqui contidas. Particular referência é feita a detecção de patógenos RNA baseada, como H5 da gripe.

DETECÇÃO DE PRIMER SIMULTÂNEA QUANTITATIVA MULTIPLE de Clostridium difficile

Esta invenção compreende um oligonucleotídeo multiplex com capacidade de que é capaz de hibridação a pelo menos um dos tcdB C. difficile, a CTPD, ou genes cdtB, onde, em que o dito primário consiste de um s..

MÉTODOS DE DETECÇÃO DE FONTES DE CONTAMINAÇÃO microorganismo

Métodos de detecção de uma fonte de contaminação microbiana em uma amostra suspeita incluem a detecção de pelo menos um membro selecionado do grupo que consiste de uma sintase geosmina microbiana, um microbiana de 2 m ..

DISPOSITIVO E NÃO TÓXICO composições e métodos para permeabilização DE EMBRIÕES DROSOPHILA

A invenção fornece composições e métodos para embriões de insetos permeabilização, removendo a camada cerosa do shell usando uma solução contendo um terpeno cíclico não-tóxico e um Surfact non-toxic ..

Prever o risco hemostático

Destaque são os métodos para avaliar o risco hemostático, incluindo o risco de ACS.Tais métodos incluem a aquisição de sangue / plasma de composição com base em uma amostra biológica obtido a partir de um sujeito, determinando ..

MÉTODOS DE DETECÇÃO DE XIA fator e fator tecidual

A invenção fornece composições e métodos para a detecção de Fator XI ou fator tecidual (TF) de atividade em uma amostra com um anticorpo do ensaio de coagulação baseado prolongamento do tempo. O disposto invenção ..

A co-administração de um trombolítico e um anticorpo anti-CD18 no curso

Um método para melhorar os resultados clínicos em AVC isquêmico focal em um mamífero aumentando o fluxo sanguíneo cerebral e / ou reduzir o tamanho do infarto é descrito que envolve administrar uma amoun eficaz ..

MÉTODOS E PRODUTOS RELACIONADOS AO REGULAMENTO GSK3BETA

A invenção se refere a métodos e composições para a regulação da atividade GSK3 [beta]. A invenção fornece fosforilada GSK3 [beta] polipeptídeos e anticorpos que reconhecem tais polipeptídeos. ..

USO DE ANTICORPO ELISPOT células secretoras para avaliar as respostas ANTICORPO após a exposição ANTÍGENO

Divulgados são os métodos e kits para a detecção precoce da exposição ao antígeno, através da presença ou ausência de antígeno-anticorpos específicos.

BIDIMENSIONAL fotônicos ESTRUTURAS PARA bandgap ultra-sensibilidade biosensoriamento

A presente invenção refere-se a matrizes bidimensionais de cristal fotônico e seu uso em chips sensores biológicos, incluindo aqueles na forma de dispositivos microfluídicos. Métodos de fazer os dois Dimens ..

NUCLEICO compostos de ácido ENCADERNAÇÃO E MÉTODOS DE USO

A presente invenção refere-se a homo-e hetero-dímero compostos formados por um dissulfeto, tio sulfinil, ou vínculo de olefinas entre dois monômeros. Um método de fazer um composto homo ou hetero-dímero é também ..

USO DE NÃO-nucleofílica ADITIVOS PARA A REDUÇÃO DE ANOMALIAS EM SUPERFÍCIE MORFOLÓGICA ARRAYS PROBE

A presente invenção refere a um formulações e métodos para acoplamento de um reagente (ou precursor sonda) a uma superfície funcionalizada para fins de formação de um sensor de vestidos. Este método inclui a ..

NURR1 PROTEÍNA INTERAGINDO (NUIP)

Fornecidos aqui métodos de promover a atividade de Nurr1 em uma célula que compreende contatar a célula com NuIP ou um análogo ou fragmento do mesmo.Também são fornecidos métodos de tratamento ou prevenção ..

Não-andrógeno papéis dependente para receptor de andrógeno no cancro do fígado

São divulgadas composições e métodos para a atividade AR modulação, como a não-atividade androgênica AR dependente. Também são divulgadas composições e métodos para o diagnóstico de câncer de besta e para inhibitin ..

Medição automatizada da placenta

Um método para analisar a placenta e lâminas histológicas de tecido placentário compreendendo: selecionando uma amostra da placenta a ser analisado; obtenção de uma imagem digital da amostra da placenta, e realizar ..

Gene diferencialmente expressos na mama e do cancro de bexiga e polipeptídeos codificados

A presente invenção refere-se a um novo gene humano que é diferencialmente expressos em carcinoma humano. Mais especificamente, a presente invenção refere-se a métodos de tratamento ou prevenção de uma disorde ..

Detecção óptica E MONITORAMENTO DO CÂNCER USANDO UMA PROTEÍNA biomarcador

Um método de detecção e estadiamento pré-invasivas e invasivas do câncer cervical é divulgada. Um tecido do colo do útero é iluminado in vivo com uma luz incidente.Emissões espectrais do a. tecido cervical.

Nogo-receptores e métodos de uso

Divulgadas são composições relacionadas ao receptor Nogo (NGR) família, bem como fragmentos, quimeras e suas variantes. A invenção fornece polipeptídeos, ácidos nucléicos, vetores, syst expressão ..

MÉTODOS E COMPOSIÇÕES RELACIONADAS COM RESPOSTAS sinérgica de mutações em oncogenes

Divulgadas são composições e métodos relacionados a novos alvos para o tratamento do câncer.

Dispositivo de câmara de fluxo contínuo para a separação, concentração e / ou purificação de células

A presente invenção refere-se a métodos e aparelhos para a separação de células.Em particular, a invenção refere-se a separação de um tipo particular de célula de uma mistura de diferentes tipos de células com base ..

Alteradas Ospa de Borrelia burgdorferi

Contidas neste documento são polipeptídeos Ospa de Doença de Lyme-Borrelia causando apresentar alteração certos (s). Em uma modalidade, a alteração (s) aumentar a estabilidade conformacional da Ospa polypeptid ..

Rearranjo cromossômico

Materiais e métodos para a detecção e mapeamento de rearranjos cromossômicos em uma amostra biológica são fornecidos. Em geral, o ensaio envolve a síntese de ácido nucléico detectável rotulados e..

Helper-Virus Free Herpesvirus Partículas Amplicon e usos deles

A invenção apresenta livre de vírus helper novos métodos para a tomada de partículas amplicon herpesvirus que pode ser usado em imunoterapias, incluindo aqueles para o tratamento de qualquer número de doenças infecciosas e c..

FACTOR VIII recombinante tendo aumentado ESTABILIDADE.

A presente invenção diz respeito a um fator VIII recombinante que inclui uma ou mais mutações que resultam em maior estabilidade de ambos fator VIII e fator VIII.Métodos de fazer e usar o r..

DC-STAMP ANTICORPOS

Contidas neste documento são anticorpos que se ligam especificamente um epítopo de DC-STAMP. Especificamente, aqui fornecidas são anticorpos monoclonais que se ligam um epítopo de DC-STAMP, onde o epítopo compreende ª ..

TECNOLOGIA ULTRA-SOM PARA CONTROLAR A organização espacial de células e proteínas IN tecidos artificiais

A presente invenção é dirigida a métodos de induzir a organização espacial de células in vitro sistema de cultivo utilizando a tecnologia de ultra-som. A invenção é ainda dirigida a métodos de induzir ..

Espacialmente INHOMOGENOUSLY funcionalizados meios porosos E MÉTODO PARA USO EM remoção seletiva de contaminantes

Composições e métodos para a separação de double-stranded ácidos nucléicos de uma mistura de single-stranded ácidos nucléicos e / ou dNTPs e / ou enzimas. O método usa fu espacialmente inhomogenously ..

COMPOSIÇÕES E MÉTODOS PARA SINALIZAÇÃO INIBIÇÃO DE PROTEÍNAS G

Divulgadas são composições e métodos para tratar doenças associadas com a proteína G [beta] [gamma] atividade subunidade.

Modelo animal para osteoartrose e doença do disco intervertebral

Aqui previsto é um animal transgênico cujo genoma é composto por uma seqüência de ácido nucléico que codifica uma primeira fusão polipeptídeo, no qual o polipeptídeo de fusão compreende um recombinase Cre e uma liga mutação ..

INIBIDORES MLK E MÉTODOS DE USO

Fornecidas são compostos tendo um efeito inibitório sobre Quinases Lineage misto.Também são fornecidos composições farmacêuticas, métodos de preparar os compostos, intermediários sintéticos, e métodos de ..

PREVENÇÃO E TRATAMENTO SEPSE

Fornecidas são polipeptídeos compreendendo uma variante de proteína C ativada compreendendo uma ou mais substituições de aminoácidos selecionada do grupo consistindo de K146R, D172N, C212R, K146G, R147G, R177G e co ..

SOLÚVEL BAIXA DENSIDADE proteína receptora LIPOPROTEÍNA RELACIONADOS liga-se diretamente ao peptídeo beta-amilóide ALZHEIMER-

Um derivado solúvel do receptor de baixa densidade da lipoproteína relacionados proteína-1 (sLRP-1) liga-se diretamente à doença de Alzheimer-amilóide [beta] peptídeo (A [beta]). Esta ligação pode ser usado para detectar uma [beta] ou setembro ..

MELHORAR O efeito terapêutico da acupuntura com ADENOSINA

A presente invenção refere a um método de melhorar o efeito terapêutico da acupuntura em um assunto. O método envolve a administração de adenosina, um mimetric adenosina, um modulador de adenosina, a..

PRODUÇÃO DE Papilomavírus Humano capsídeo protéico e partículas semelhantes a vírus

A presente invenção é direcionada a um método de expressar o papilomavírus seqüência da proteína do capsídeo de codificação em uma célula usando um sistema de expressão sob condições que facilitem a expressão da prote ..

PSA E KLK2 como alvos terapêuticos e moléculas PSA inibição e KLK2

Aqui são divulgadas composições e métodos relacionados com antígeno prostático específico (PSA), KLK2 e receptor de andrógeno. Além disso são fornecidos métodos e composições para inibir a PSA e / ou acti KLK2 ..

Tiorredoxina Protein Interação (TXNIP) como regulador da Função Vascular

A presente invenção refere-se a testes de rastreio para a identificação de agentes que podem modificar a interação de proteínas que interagem thioredoxin (TXNEP) em thioredoxin (TRX) 5 preferência por inibidores ..

Crescimento de Fibroblastos FACTOR (FGF) análogos E USOS DOS MESMOS

A invenção refere-se novo peptídeo compreendendo FGF-P e métodos de uso dos mesmos.

Tratamento de doenças mielina com preparações de células OTIMIZADA

A divulgação diz respeito a oligodendrócitos-biased células progenitoras gliais e métodos de fazer, isolar, e usando essas células.

SUPRESSÃO DE TUMOR ATRAVÉS PLEXIN C1

São divulgadas composições e métodos relacionados com a Plexin C1 e diagnosticar, tratar e avaliar o tratamento para o câncer.

MÉTODOS DE TRATAMENTO B CELL-cânceres

A presente invenção é direcionada para métodos de causar maligno as células B malignas e tratamento de células-B. Estes métodos envolvem o uso de um inibidor de atividade do PKK, se ativa diretamente contra ..

Uso de inibidor de proteína tirosina como a genisteína no tratamento da retinopatia diabética ou inflamação ocular

Problema a ser resolvido: Para fornecer um método para o tratamento profilático e terapêutico da retinopatia diabética e um método para o tratamento profilático e terapêutico inflamação ocular. ; S..

ABLAÇÃO USINAGEM LASER BASE DE PADRÕES biomolécula em substratos

Um método para padronização uma ou mais biomoléculas em um substrato que inclui revestimento do substrato com um revestimento de um ou mais biomoléculas, a aplicação de um laser para o revestimento, e ablação de um po ..

COMPOSIÇÕES E MÉTODOS PARA EX VIVO DE ENTREGA DE ÁCIDO NUCLEICO HEPÁTICA

A invenção fornece composições e métodos para a entrega de ácidos nucléicos ao vivo ex fígado. O método inclui lenta, a infusão de baixa pressão do ácido nucléico para o fígado de forma eficiente tr ..

A NOVEL modelo in vitro HIV-1 LATENCY PARA AGENTES DE TRIAGEM DE REATIVAÇÃO HIV-1

Em um aspecto, a presente invenção fornece um isolado Bcl-2-transduzidas célula que compreende, integrado no genoma da célula, a transcrição competente vírus da imunodeficiência ou uma transcrição ..

DETECÇÃO E CLASSIFICAÇÃO DNA metilado USANDO UM nanopore SYNTHETIC

Fornecidos são métodos para detectar, caracterizar ou separando DNA com base na metilação. Populações heterogêneas DNA são separadas com base na metilação do DNA, fornecendo uma membrana tendo uma nanopor ..

ANNEXINA2 TARGET AS IMUNOLÓGICAS

AnnexinA2 (ANXA2), um membro da família anexina de cálcio dependentes de fosfolipídios, proteínas de ligação, é um de um painel de antígenos identificados reconhecido pelo soro pós-vacinação de pacientes que ..

CÉLULAS DE MANIFESTAÇÃO aumento da proteína compreendendo um ou mais fatores de liberação e métodos de uso

A invenção fornece células recombinantes ou recombinante células restritivas para superexpressão de uma ou mais proteínas compreendendo um ou mais fatores de liberação. A invenção também fornece métodos para produção ..

Fator Induzido por Hipóxia mitogênica

Descobrimos que FIZZ1/RELM [alpha] é induzível por hipóxia no pulmão. A expressão de hipóxia-upregulated FIZZ1/RELM [alpha] foi localizado na vasculatura pulmonar, células epiteliais brônquicas, e tipo ..

Leucina-rica repetir quinase (LRRK2) drosófila modelo para a doença de Parkinson: wildtype1 (WT1) e moscas mutantes G2019S

Mutações no quinase repetições ricas em leucina (LRRK2) causam gene de início tardio autossômica dominante doença de Parkinson (DP) com patologia pleiomorphic. Anteriormente, nós e outros descobriram que a expressão de mu ..

PEPTÍDEOS E USOS DOS MESMOS PARSTATIN

A invenção proporciona peptídeos parstatin, especialmente um peptídeo parstatin de mamíferos, incluindo aminoácidos 1-26 de parstatin comprimento total de mamíferos, de preferência um parstatin humana. A invenção fornecer ..

MÉTODOS DE tratamento de tumores cerebrais com anticorpos

A aplicação é direcionada para um método de tratamento de um tumor cerebral em um paciente que compreende sistemicamente administração de um anticorpo monoclonal.

MÚLTIPLOS degradáveis POLÍMEROS CATIÔNICOS

Polímeros biodegradáveis foram sintetizados que a auto-montagem com o DNA para formar partículas que são eficazes para a entrega do gene. Pequenas alterações às condições de síntese de polímeros, as condições de formulação de partícula, ..

ESPECTROSCOPIA MOLÉCULA ÚNICO PARA ANÁLISE DE CÉLULA-FREE BIOMARCADORES Ácido Nucleico

A presente invenção refere, por exemplo, a um método para a detecção de uma molécula de ácido nucléico de interesse em uma amostra de células de ácidos nucléicos, compreendendo fluorescente rotulagem do ácido nucléico mo ..

Amplificação ilha CpG metilados (MCA)

A presente invenção fornece um método para identificar um metilados de ácido nucléico contendo CpG entrando em contato com um ácido nucléico com uma endonuclease de restrição sensíveis a metilação, que cliva unmethy ..

CADEIA DE RECEPTOR CITOCINA

Problema a ser resolvido: Para fornecer um fragmento receptor tendo uma afinidade para IL-13, um método para produzir o mesmo, e tratar o uso do mesmo. ; SOLUÇÃO: A polinucleotídeo ter uma sequ específicas ..

CÂNCER STEM CELL padrões de expressão E COMPOSTOS DE CÉLULAS-TRONCO TARGET CÂNCER

Aqui descritos são alvos terapêuticos expressa em células-tronco cancerosas e métodos para o tratamento e diagnóstico do câncer, visando tais células com anticorpos, os compostos, o ácido nucléico, ou therap outros ..

SOCS-1 Metilação Gênica em Câncer

Métodos são fornecidos para a identificação de uma célula exibindo crescimento desregulado associados metilação silenciados transcrição de um supressor de sinalização de citocina (SOCS) / citocina indutível proteína SH2 ..

Anticorpos que se ligam especificamente Hedgehog Derivados Polipeptídeos

A presente invenção fornece dois polipeptídeos romance, referido como o "N" e "C" fragmentos de ouriço, ou N-terminal e C-terminal fragmentos, respectivamente, que são derivados após clea específicas ..

CO-POLÍMERO estabilizadores para DISPERSÕES hidrofluoroalcano

O uso de biodegradáveis e biocompatíveis ácido lático-base anfifílicos não iônico para estabilizar uma droga modelo (salbutamol base) dispersão no propulsor hidrofluoroalcano (HFA) é divulgado. O hav resultados ..

Células T ativadas

Fornecidas são composições compreendendo ativação de células T e células T ativadas armados com anticorpos dirigidos a antígenos bispecific câncer que são pouco responsivos aos aloantígenos, e métodos de usar ..

MÉTODO E COMPOSIÇÃO PARA A TECNOLOGIA TRANSDUÇÃO PROTEÍNA E SUAS APLICAÇÕES

Um método de transdução de proteína para entrega eficiente de proteínas exógenas em células de mamíferos é inventado, que tem a capacidade de segmentação diferentes compartimentos celulares e proteção contra ..

2,2-Bis (hidroximetil)-cyclopropylidenemethyl Purinas e Pirimidinas-Como Antivirais

Compostos que são ativos contra os vírus têm as seguintes fórmulas: onde B é uma purina ou pirimidina anel heterocíclico ou base. Em uma modalidade preferida, a purina incluem 6-aminopurina (aden..

GÊNERO-WIDE antígenos vacinais CLAMÍDIAS PEPTIDE

Peptídeos gerados a partir de uma biblioteca aleatória que estão vinculados por um anticorpo monoclonal para exoantígeno glicolipídeo clamídias (GLXA) e, assim, imitar este antígeno são divulgados. Peptídeos que correspondem a antig ..

Biomarcadores para métodos diagnósticos e terapêuticos

Eritrócitos ATP-lançamento moduladores e composição e métodos para seu uso como biomarcadores de processamento de glicose ou distúrbios vasculares, bem como métodos para triagem para identificar a moduladores; meth ..

Galectina-3 clivagem como um marcador de atividade de metaloproteinases da matriz no câncer

Fornecidos são os anticorpos diferencial reconhecendo as formas clivadas e não clivadas das metaloproteinases de matriz (MMP), e métodos de usar os anticorpos como marcadores de diagnóstico para a pres ..

Amidas TERAPÊUTICO

A invenção fornece compostos da fórmula: em que X, Y e Z são como definidos na especificação. Os compostos são eficazes agentes anti-tumor. A invenção também fornece comp farmacêutica ..

MODIFICADOS EGFR ectodomínio

Uma proteína que atenua EGFR e / ou membros da família EGFR compreende um EGFR modificada ectodomínio. A proteína inibe a sinalização através do EGFR e / ou membros da família EGFR. A proteína inclui uma porção o..

CYCLIC-GLUR6 análogos, MÉTODOS DE TRATAMENTO E UTILIZAÇÃO

Uma composição que é inibidor reversível de pelo menos um neurônio-específica de domínio PDZ estrutura que inclui no qual (5), R é um transportador molecular com ou sem um ácido amino linker; R1 está em leas ..

Híbrido 2-aminoterailin e compostos de piperazina aril-substituídos e sua utilização em alterar a atividade do SNC

Compostos contendo uma porção híbrida aminotetralin ou um análogo de cadeia heterocíclicos e / ou abrir suas ligados através de um grupo alquileno de um anel de arila substituídos sistema exibem porção piperidiene oi ..

POLIAMINAS útil como THERAPEUTICS anti-parasitários e anti-câncer E COMO INIBIDORES LISINA ESPECÍFICAS demetilase

Poliamina, poliamina / guanidino, e compostos de poliamina / biguanida são divulgados. Os compostos são úteis como tratamentos anti-câncer e anti-parasitários. Os compostos também são úteis como inibidores de t..

Método para identificar uma subpopulação de células de mamíferos com DISTINTIVOS PERFIS DE TRADUÇÃO ribossomo

A presente invenção geralmente refere-se a subpopulações de células de mamíferos com distintivo ribossomo perfis de translação, ou seja, atividades de translação. A presente invenção também refere-se a m..

Não-Natural Peptídeos como modelos para o desenvolvimento de antibióticos

Aqui descritos são métodos de rastreio um dos grampos RNA na subunidade ribossômica pequena de bactérias para identificar peptídeos que se ligam a ele. O alvo hairpin RNA pode ser o laço 970 (hélice aka ..

PARTÍCULAS DE ENGENHARIA porosa de THERAPEUTICS SOLÚVEL EM ÁGUA PARA FORMULAÇÕES PRESSURIZADO inalador dosimetrado

O assunto aqui divulgado refere-se a métodos para partículas porosas de engenharia da terapêutica solúvel em água, com estabilidade física melhorada e características do aerossol em hidrofluoroalcano ..

Distribuição homogênea da suspensão celular em material de suporte poroso para engenharia de tecidos com o uso do corpo moldado com abertura da câmara ter, compreende introduzir o material de suporte provid

O processo de distribuição homogênea de uma suspensão celular em um material de suporte poroso (3) para engenharia de tecidos sob usando um corpo moldado (1) com uma câmara (2) tendo uma abertura para receivi ..

PROCESSO PARA A PREPARAÇÃO DE COMPOSTO ciclodextrinas de mais de oito unidades de glicose

Um processo para a preparação de ciclodextrinas de anel grande (LR-CD) com um grau de polimerização (DP) de 9-21 a partir de amido é descrito. LR-CD são obtidos em um processo biocatalítico na b. altos rendimentos.

PROMOÇÃO DA FUNÇÃO CATALASE Peroxissômicos EM CÉLULAS

Os mecanismos moleculares da biogênese de peroxissomos começaram a surgir, em contraste, pouco se sabe sobre como as funções organela como envelhecem as células. Os inventores atual, caracterizado idade ..

Policlonal BISPECIFIC COMPOSIÇÕES ANTICORPO E MÉTODO DE USO

A invenção refere-se a composições e métodos para o tratamento de um hospedeiro infectado com um patógeno. A composição que compreende uma população de policlonal bispecific moléculas de ligação que pode ter como alvo e e..

COMPOSIÇÕES E MÉTODOS PARA DETECTAR e modulando a morte celular por um sistema de expressão TRADUÇÃO REGULAMENTADO GENE

A tecnologia se relaciona com uma cassete de ácido nucléico expressão compreendendo um elemento de codificação TR uma molécula de mRNA que é traduzido em células estressadas e / ou morrendo, e uma seqüência de nucleotídeos operavelmente lin ..

ANTI-CANCER THERAPEUTIC STRATEGY TO OVERCOME CANCER RESISTANCE AND TO ENABLE TAILORING TREATMENT TO PATIENTS

A gene construct comprising a programmed-cell-death executioner gene having a nuclear localization signal, a deleted signal peptide, an actin-resistant binding site, a promoter, and an activator. A me..

THERAPEUTIC COMPOSITIONS AND METHODS FOR DELIVERY OF ACTIVE AGENTS CLEAVABLY LINKED TO NANOPARTICLES

Various embodiments of the present invention pertain to therapeutic compositions that comprise: (1) an active agent (e.g., paclitaxel); and (2) a nanoparticle (e.g., gold nanoparticle). In such embodi..

METHODS OF FABRICATING ENHANCED TISSUE-ENGINEERED CARTILAGE

Compositions and methods for fabricating a tissue-engineered cartilage construct comprising: providing a cell sample comprising a plurality of chondrocytes; culturing the cell sample to produce a tiss..

SYSTEMS AND METHODS FOR MAGNETIC GUIDANCE AND PATTERNING OF CELLS AND MATERIALS

Systems and methods generally useful in medicine, cellular biology, nanotechnology, and cell culturing are discussed. In particular, at least in some embodiments, systems and methods for magnetic guid..

SYSTEMS AND METHODS FOR PRODUCING PLASTID PROTEINS

Methods and systems that include a method comprising: providing a system comprising one or more plastid proteins comprising a signal sequence and one or more chloroplast processing enzymes; and allowi..

SPERMICIDAL AND MICROBICIDAL COMPOSITIONS

Provided herein are new spermicidal compositions that include one or more fluorous surfactants, e.g., non-ionic fluorous surfactants, anionic fluorous surfactants, cationic fluorous surfactants, and c..

BISPHOSPHONATE-PROSTATIC ACID PHOSPHATASE INHIBITOR CONJUGATES TO TREAT PROSTATE CANCER BONE METASTASIS

The present invention concerns conjugate compounds comprising a bisphosphonate covalently bonded to a prostatic acid phosphatase inhibitor and compositions comprising such conjugates. Methods for trea..

SERUM MARKERS ASSOCIATED WITH EARLY AND OTHER STAGES OF BREAST CANCER

Methods for identifying disease-specific markers, in particular breast cancer markers, by electrophoretically separating serum albumin complexes in a biological sample on a membrane are provided. Elec..

COMPOSITE BONE GRAFTS, PARTICULATE BONE-CALCIUM SULFATE CONSTRUCTS, AND METHODS OF TREATING JOINT INJURIES

A solid implantable bone construct (12) shaped like a cylinder, a cone, or a frustum, for anchoring ligament implants. The bone construct (12) can include a bone component and a biocompatible solid co..

ANTIBACTERIAL PEPTIDES ACTIVE IN SYSTEMIC INFECTIONS

Antimicrobial peptides of the formula are provided: X1-X2-PrO- X3- X4-PrO- Arg- Pro-Tyr-Leu-Pro- X5-Pro-Arg-Pro-Pro-Arg-Pro-Y, wherein X1 is a natural or non-natural amino acid having a free amino gro..

MANIPULATING SP1 ACTIVITY TO IMPROVE THERAPEUTIC CLONING

The observed over-expression of Sp1 target genes has inspired inventors to formulate a specific strategy for correcting many gene expression defects, and thus improve clone development. The invention ..

AN ASSAY FOR SCREENING/RANKING ANTIOXIDANTS BASED ON THEIR EFFECTS ON MEMBRANE STEROL LATERAL ORGANIZATION

A method of screening an antioxidant for potency and/or toxicity in vitro, the method includes contacting the antioxidant with a model system comprising a sterol superlattice formation capable of gene..

USE OF NIBP POLYPEPTIDES

Methods for regulating NF-?B activation in cells comprising introducing into the cell a vector comprising a nucleic acid sequence encoding a NIK and IKK2 Binding Protein (NIBP) polypeptide, wherein th..

TRIGGERABLY DISSOLVABLE HOLLOW FIBERS FOR CONTROLLED DELIVERY

Provided are tubular structures of a biocompatible, triggerably-dissolvable material such as cellulose or a copolymer having an LCST below physiological temperatures. The structures may be embedded wi..

BIOSENSORS AND RELATED METHODS

Provided herein are biosensors that comprise a biological signal source linked to a substrate by a peptide nucleic acid spacer and methods of use of the biosensor. In one embodiment, the biosensor is ..

MICRORNAS IN IDIOPATHIC PULMONARY FIBROSIS

The present invention relates to the discovery that certain microRNAs are differentially expressed in Idiopathic Pulmonary Fibrosis. The present invention provides for diagnostic methods, therapeutic ..

NITRO FATTY ACIDS AS REGIOMERS AND RELATED MIMETICS

Mimetics of nitro linoleic acid are potent agonists of PPAR-?, a receptor that regulates adipocyte differentiation, glucose homeostasis and insulin sensitivity. Thus, 10-LNO2 and 12-LN-NO2 are potent,..

POLYPEPTIDES AND USES THEREOF

The invention provides a polypeptide having a sequence comprising from 10 to 24 consecutive amino acids from residues 215-233 of the sequence of human cyclin B1 protein or homolog thereof, as well as ..

CYTOTOXIC T CELL DEFINED EGFR PEPTIDE AND AN OPTIMIZED DERIVATIVE PEPTIDE

The invention provides a polypeptide having a sequence of amino acids consisting of IXDFGLAKL (SEQ ID NO: 1), as well as a nucleic acid encoding the polypeptide, vector comprising the nucleic acid, ce..

NOVEL BIOSENSORS FOR LIVE CELL IMAGING OF INTRACELLULAR PROTEINS

This invention is related to the field of imaging intracellular protein processing. Fluorescent probes capable of changing color over time are used to identify and track the synthesis, trafficking, an..

TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX

Drug candidates for inhibition of HIV-I replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory activity w..

CANCER STEM CELL IMMORTALIZATION

The present invention relates to the preparation and use of immortalized cancer stem cells. The immortalized cancer stem cells of the invention may be used in assays to identify anti-cancer compounds ..

EARLY PROSTATE CANCER ANTIGEN-2: A NOVEL SERUM SPECIFIC MARKER FOR PROSTATE CANCER DETECTION

Early Prostate Cancer Antigen-2 (EPCA-2) is a prostate cancer biomarker, newly identified via proteomics-based examination of alterations in nuclear structure. EPCA-2 shows a higher overall specificit..

SUBSTANCE P AND ANALOGS THEREOF AS A CANCER IMMUNOGENIC COMPOSITION ADJUVANT

Disclosed herein are methods and compositions effective for treating, preventing, and ameliorating cancer that utilize Substance P or Substance P analogs and antigens. Also disclosed are methods for v..

METHODS OF LABELING BIOLOGICAL SAMPLES

Methods are provided for labeling specific oxidized proteins. Methods also are provided for determining the oxidation state of a cell. Such methods are useful as diagnostic, therapeutic and screening ..

ADIPOSE-DERIVED STEM CELLS AND LATTICES

The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and ..

CELL LINE

The invention provides a cell line complementing HSV ICP4, ICP27, and UL55 genes.

THERAPEUTIC AND DIAGNOSTIC CLONED MHC-UNRESTRICTED RECEPTOR SPECIFIC FOR THE MUC1 TUMOR ASSOCIATED ANTIGEN

The invention provides an isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC1 tumor antigen independently of an major histocompatibility compl..

ARTIFICIAL CELL CONSTRUCTS FOR INDUCING IMMUNOLOGICAL TOLERANCE

The present invention contemplates induction of immunological tolerance thereby providing permanent allograft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive agen..

HUMAN LEUKOCYTE ANTIGEN ALLELES ASSOCIATED WITH ADVANCED LUNG DISEASES

The present invention relates to methods and compositions that may be used to predict the risk of an individual, for example a smoker, for developing chronic obstructive pulmonary disease ("COPD"), em..

THERMORESPONSIVE, BIODEGRADABLE, ELASTOMERIC MATERIAL AND USES THEREFOR

Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers are non-toxic and typically have an LCST below 37 DEG C. Compositions comprising the copolymers c..

SMALL MOLECULE INHIBITORS OF DUSP6 AND USES THEREFOR

Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The compoun..

LINKED MYC-MAX SMALL MOLECULE INHIBITORS

Provided herein are compounds and compositions for interfering with the association of Myc and Max. These compounds and compositions are useful in methods for inhibiting growth or proliferation of a c..

BIOLOGIC SCAFFOLD FOR PREVENTION OF PULMONARY FIBROSIS

Provided herein are methods of preventing, lessening or treating pulmonary fibrosis in a subject. The methods comprise delivering an amount of a powdered extracellular matrix (ECM)-derived material to..

MUSCLE DERIVED CELLS (MDCS) FOR PROMOTING AND ENHANCING NERVE REPAIR AND REGENERATION

The present invention describes methods involving the use of muscle derived cells (MDCs), preferably obtained from skeletal muscle, to support the innervation and repair of damaged tissues and organs,..

FSTL-1 AS A BIOMAKER OF INFLAMMATION

The invention provides methods and kits for diagnosing severity of particular types of inflammatory diseases, such as rheumatic diseases, by assessing protein levels of follistatin-like protein 1 (FST..

Identification of markers in esophageal cancer

Methods for identifying expression of markers indicative of the presence of esophageal, a squamous cell cancer, a squamous cell cancer of the head and neck, colon cancer and melanoma are provided. Als..

BONE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS IN BIOCOMPATIBLE MATRIX, AND TREATMENTS THEREOF

The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e...

TARGETED NITROXIDE AGENTS

Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a..

Biomarkers For Prognosis of Pulmonary Diseases

The present invention relates to biomarkers that may be used to evaluate the prognoses of patients suffering from pulmonary diseases and assist in the determination of appropriate therapeutic regimens..

BIOERODIBLE WRAPS AND USES THEREFOR

A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun..

Porous Biomolecule-Containing Metal-Organic Frameworks

The present invention relates to compositions including porous biomolecule-containing metal-organic frameworks and methods for their preparation. The porous biomolecule-containing metal-organic framew..

OXYGEN DEPLETION DEVICES AND METHODS FOR REMOVING OXYGEN FROM RED BLOOD CELLS

An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within ..

ENGINEERED MICROPARTICLES FOR MACROMOLECULE DELIVERY

A method for making a modified release composition, comprising: selecting a desired active agent and polymer matrix for formulating into a modified release composition; assessing degradation effect on..

METHODS FOR EXPANDING REGULATORY T-CELLS

The present invention relates a method of expanding and enriching a regulatory T-cell population. Specifically, the invention relates to methods of expanding regulatory T-cells by contacting leukocyte..

CO-CRYSTAL OF ANTIBODY 11F8FAB FRAGMENT AND EGFR EXTRACELLULAR DOMAIN AND USES THEREOF

The present invention relates to co-crystals of antibody 11F8 Fab fragments and the complete extracellular domain of EGFR or isolated domain III of EGFR, and structural coordinates obtained from such ..

USE OF AN ANTIBODY AND A RARE-EARTH BASED CRYSTAL

[00152] The present invention provides compositions and methods for the detection of red blood cells antigens. The methods and compositions are based on antibodies, serving as primary antibodies or se..

COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF HIF-1 ALPHA

RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is als..

THE USE OF IL-27-P28 TO ANTAGONIZE IL-6 MEDIATED SIGNALING

Provided are methods increasing, or, alternatively, decreasing IL-6 and/or gpl30-mediated signaling in mammalian subjects using p28. Methods of preventing and/or treating autoimmune disorders, cancer,..

BIOMATERIALS FOR TISSUE REPLACEMENT

This invention relates to biomaterial compositions, methods and kits for producing hydrogels with tunable physico-chemical properties. Specifically, the invention relates to producing cellulosic hydro..

HYDROLYTICALLY DEGRADABLE POLYSACCHARIDE HYDROGELS

Provided are polysaccharide compositions capable of controllable hydrolytic degradation and suitable for controlled release of therapeutic agents. Also provided are methods for synthesizing such compo..

COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ANGIOGENESIS

RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these gene..

COMPOSITIONS COMPRISING HMW-MAA AND FRAGMENTS THEREOF, AND METHODS OF USE THEREOF

This invention provides recombinant polypeptides comprising listeriolysin fused to an antigen such as a fragment of a High Molecular Weight Melanoma- Associated Antigen (HMW- MAA), recombinant Listeri..

COMPOSITIONS AND METHODS FOR INHIBITING AN ONCOGENIC PROTEIN TO ENHANCE IMMUNOGENICITY

The present invention includes compositions and methods for inhibiting an oncogenic protein or its down-stream effector protein to suppress expression of a cell-surface protein involved in inhibiting ..

LIGAND-SPECIFIC INHIBITION OF ATTACHMENT OF IMMUNE CELLS TO IMPLANTABLE BIOMATERIALS

Methods for protecting biomater?als comprise attaching CD47 or Ig domain thereof to the surface of the biomaterial, thereby inhibiting or reducing immune cell attachment and/or immune cell-mediated da..

TRANSCRIPTOME TRANSFER PRODUCES CELLULAR PHENOTYPE CONVERSION

The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a phenot..

MODULATORS OF TDP-43 MEDIATED TOXICITY

Compositions and methods are disclosed for identifying agents useful for the treatment of proteinopathies.

MICRO-RNA BIOMARKER IN CANCER

This invention provides compositions and methods for predicting and improving a chemotherapy response to treat an ovarian cancer. In one embodiment, the invention provides compositions and methods for..

REGULATORS OF THE INTERFERON-ALPHA RECEPTOR 1 (IFNAR1) CHAIN OF THE INTERFERON RECEPTOR

The present invention includes compositions and methods for modulating a regulator of IFNARl. The invention includes inhibitors and activators of PERK, PTPlB, and/or PKD2 wherein inhibition, or activa..

SIMIAN ADENOVIRUS 41 AND USES THEREOF

Novel simian adenovirus 41 and two isolates thereof are described. Various uses of these isolates, including construction of a recombinant vector which comprises simian adenovirus 41 sequences and a h..

SIRNA COMPOSITIONS FOR INHIBITION OF HIF-1 ALPHA

Heterologous Protein Production Using The Twin Arginine Translocation Pathway

Provided are means for evaluating and identifying putative substrates of the twin arginine translocation (Tat) secretory pathway in Streptomyces and other bacterial species. Also provided, therefore, ..

SIMIAN SUBFAMILY B ADENOVIRUSES SADV-28,27,-29,-32,-33, AND -35 AND USES THEREOF.

A recombinant vector comprises simian adenovirus 28, simian adenovirus 27, simian adenovirus 32, simian adenovirus 33, and/or simian adenovirus 35 sequences and a heterologous gene under the control o..

SIMIAN SUBFAMILY E ADENOVIRUSES SADV-39, -25.2, -26, -30, -37, AND -38 AND USES THEREOF.

A recombinant vector comprises simian adenovirus SAdV-39, -25.2, -26, - 30, -37, and -38 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian..

Activation and Expansion of T-Cells Using An Engineered Multivalent Signaling Platform as a Research Tool

Provided are a system and methods for selectively inducing expansion of a population of T cells in the absence of exogenous growth factors, such as lymphokines, and accessory cells for research purpos..

CONTROLLED ADENO-ASSOCIATED VIRUS (AAV) DIVERSIFICATION AND LIBRARIES PREPARED THEREFROM

A method for the directed production of a combinatorial library of an altered protein coding sequence is described. The method involves predetermining at least two different nucleotide sequence fragme..

METHODS AND COMPOSITIONS FOR IN-VIVO ENZYME CAPTURE

The invention includes compositions, methods and kits for the in vivo identification of an enzyme that binds to a substrate. The invention comprises, in part, a photoreactive moiety to aid in identifi..

AMINOTHIENOPYRIDAZINE INHIBITORS OF TAU ASSEMBLY

The present invention is directed to methods of inhibiting a tauopathy in a patient by administration of a compound of formula (I): Novel aminothienopyridazine compounds are also described.

NOVEL MOLECULAR BEACONS

The invention provides novel compositions and methods for the detection of a target molecule. Specifically, the invention provides a bimolecular beacon composition comprising two nucleic acid molecule..

ARTIFICIAL MENISCAL IMPLANTS

Provided are three dimensional shaped porous, fibrous polymer scaffolds capable of mimicking the functional properties of native tissue of a knee meniscus, and methods for manufacturing and using said..

SINGLE DIASTEREOMERS OF 4-FLUOROGLUTAMINE AND METHODS FO THEIR PREPARATION AND USE

The present invention is directed single diasteromers of 4-fluoroglutamine having a diastereomeric excess of at least 80%. Methods of preparing the single diastereomers are also described, as well as ..

AMPHIPHILIC JANUS-DENDRIMERS

The invention concerns compounds of the formula: X-(Y)t wherein: X is Formula (X), each Y is the same or different and is Formula (Y) -O-[CH2-CH(OH)-CH2-O-]m-H; or -C(OR5)3; R1, R2, R3, R6, R7, R8, R9..

Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use

A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. M..

O-methylated rapamycin derivatives for alleviation and inhibition of lymphoproliferative disorders

The present invention relates to methods of alleviating and inhibiting a Iymphoproliferative disorder in a mammal, the method comprising administering one or more rapamycin derivatives (including rapa..

FN14/TRAIL FUSION PROTEINS

Fusion proteins which act on the TWEAK and TRAIL signaling axes are provided. The proteins are useful in the treatment or amelioration of autoimmune diseases, particularly multiple sclerosis, as well ..

Novel artificial antigen presenting cells and uses thefor

The invention relates to novel artificial antigen presenting cells (aAPCs). The aAPC comprises at least one stimulatory ligand and at least one costimulatory ligand where the ligands each specifically..

FUNCTION AND REGULATION OF ADAMTS-1

The present invention relates to ADAMTS-1 and uses thereof. The present invention also relates to fragments of ADAMTS-1 and methods of inhibiting cell growth and metastasis. The present invention also..

Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same

Fusion proteins and nucleic acid molecules encoding fusion proteins are disclosed. Fusion proteins comprising non-IL-15 signal peptide linked to IL-15 protein sequences and fusion proteins comprising ..

SMALLPOX DNA VACCINE AND THE ANTIGENS THEREIN THAT ELICIT AN IMMUNE RESPONSE

The present invention relates to DNA vaccines that are capable of generating a protective immune response in mammals against a pox virus, and comprises at least one DNA plasmid capable of expressing a..

Disc-Like Angle-Ply Structures for Intervertebral Disc Tissue Engineering and Replacement

Provided are implant scaffolds comprising angle-ply arrays of two or more layers of substantially aligned fiber, methods of making and using said scaffolds, and kits comprising such scaffolds.

Neprilysin Gene Polymorphism and Amyloid Beta Plaques in Traumatic Brain Injury

The invention relates to methods of diagnosing risk of amyloid [beta] deposition following traumatic brain injury. More particularly, the invention relates to the discovery of a specific single nucleo..

COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ICAM-1

RNA interference using small interfering RNAs which are specific for the ICAM-1 gene inhibits expression of this gene. Diseases which involve ICAM-1-mediated cell adhesion, such as inflammatory and au..

DNA VACCINES ENCODING HIV ACCESSORY PROTEINS

Improved vaccines and methods of using the same are disclosed. Immunosuppressive compositions for treating individuals who have autoimmune diseases or transplants and methods of using the same are dis..

COMPOSITIONS AND METHODS FOR REGULATING CYTOCHROME C-MEDIATED APOPTOSIS BY tRNA

The invention relates to the discovery that tRNA is a potent regulator of cell survival. tRNA regulates the interaction between cytochrome c and Apaf-1 and subsequently Apaf-1 oligomerization into an ..

GENERATION OF HYPERSTABLE mRNAs

Provided herein is a method for enhancing the stability of a mRNA molecule. Specifically, the invention provides methods of increasing stability or augmenting expression of mRNA or its products by ins..

NON-HEMOLYTIC LLO FUSION PROTEINS AND METHODS OF UTILIZING SAME

The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholestero..

MODIFIED ADENOVIRUS HEXON PROTEIN AND USES THEREOF

The present invention provides a method of altering the specificity of an adenovirus vector. The method involves providing an adenovirus having a capsid with a modified adenovirus hexon protein. The m..

SMNDELTA7 DEGRON: NOVEL COMPOSITIONS AND METHODS OF USE

The present invention includes an isolated nucleic acid comprising a nucleic acid sequence encoding a SMN?7 degron and the encoded polypeptide. The invention also includes inhibitors of SMN?7 degron. ..

METHOD OF INHIBITING BIOMATERIAL-INDUCED PROCOAGULANT ACTIVITY USING COMPLEMENT INHIBITORS

Methods for reducing or eliminating biomaterial-induced procoagulant activity in blood subjected to extracorporeal treatment that exposes the blood to the biomaterial are disclosed. The methods involv..

FOXP3 OLIGOMERIZATION AND INTERMOLECULAR INTERACTIONS

Methods of identifying immune response modulators are disclosed. Some methods comprise identifying chemical candidates that modulate oligomerization of FOXP3 and/or fragments thereof comprising the Zi..

Simian adenoviruses SAdV-36, -42.1, -42.2, AND -44 and uses thereof

An adenovirus is disclosed, having a capsid comprising a hexon protein of SAdV-42.1 or an amino acid sequence at least about 99% identical thereto, or a hybrid hexon protein. The capsid encapsidates a..

DETECTION OF NUCLEIC ACIDS USING A CANTILEVER SENSOR

Detection of miniscule amounts of nucleic acid is accomplished via binding of target nucleic acid to probe material, composed of nucleic acid, which is bound to a sensor configured to sense mass. The ..

ELECTROWETTING MICROARRAY PRINTING SYSTEM AND METHODS FOR BIOACTIVE TISSUE CONSTRUCT MANUFACTURING

Apparatuses and methods for manufacturing three-dimensional, bioactive, tissue scaffold fabrications with embedded cells and bioactive materials, such as growth factors, using biomimetic structure mod..

BIOADHESIVE HYDROGELS

A method of forming and the resulting bioadhesive hydrogel composition for repairing or supplementing a nucleus pulposus of an intervertebral disc comprises at least a first component, a second compon..

ENCAPSULATION OF MICROBUBBLES WITHIN THE AQUEOUS CORE OF MICROCAPSULES

The present invention includes a construct that comprises at least one microbubble encapsulated within the aqueous core of a microcapsule. The present invention also includes a pharmaceutical composit..

PLASMA TREATMENT FOR GROWTH FACTOR RELEASE FROM CELLS AND TISSUES

Aspects of the present invention are related to methods comprising contacting an endothelial cell in an endothelial cell population with a non-thermal plasma to release an angiogenic growth factor. Th..

FLOW-BASED ENHANCEMENT OF SPECIFICITY FOR LABEL-FREE BIOCHEMICAL ASSAYS

A label-free biochemical assay, in which label-free interrogation of a target-receptor layer is performed while the target-receptor layer is subjected to a relatively strong flow of an analyte-contain..

COMPOSITIONS AND METHODS FOR TREATING A DISORDER OR DEFECT IN SOFT TISSUE

The present invention encompasses methods and compositions for generating a biomimetic proteoglycan. The invention includes methods of treating a disease, disorder, or condition of soft tissue using a..

SMALL DIAMETER VASCULAR GRAFT PRODUCED BY A HYBRID METHOD

The present invention relates to a hybrid graft and methods of generating the hybrid graft. The hybrid graft comprises an exterior surface and a luminal surface. The luminal surface comprises a microp..

PHASE TRANSITIONING HYDROGELS

A method of forming and the resulting hydrogel composition comprising poly( vinyl alcohol) at a final concentration of about 20% (w/w) to about 65% (w/w) and polyethylene glycol at a final concentrati..

Self-assembled proteins and related methods and protein structures

The present invention provides user-directed construction of novel specific homo- and hetero-dimeric, and multimeric assemblages of proteins. The present invention is comprised of gene sequences that ..

METHODS OF MODULATING IMMUNE FUNCTION

Presented herein are therapeutic agents that modulate one or more immune functions and uses of such therapeutic agents in the prevention, treatment and management of diseases. In one aspect, the thera..

MEASUREMENT OF MITOCHONDRIAL MEMBRANE POTENTIAL TO ASSESS ORGAN DYSFUNCTION

The present invention relates to the field of organ transplantation. More specifically, the present invention provides methods for predicting organ function after transplantation. In certain embodimen..

PROGRAMMABLE MULTISPECTRAL ILLUMINATION SYSTEM FOR SURGERY AND VISUALIZATION OF LIGHT-SENSITIVE TISSUES

An observation system for viewing light-sensitive tissue includes an illumination system configured to illuminate the light-sensitive tissue, an imaging system configured to image at least a portion o..

BIOMARKERS FOR MYOCARDIAL ISCHEMIA

This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia;..

COMPOSITIONS AND METHODS FOR IMPLANTATION OF ADIPOSE TISSUE AND ADIPOSE TISSUE PRODUCTS

The invention provides compositions and methods for the preparation of biocompatible biomaterials from adipose tissue. Biocompatible biomaterials are cellular or acellular biomaterials. The invention ..

POTENT IMMUNOSUPPRESSIVE AGENTS, DERIVATIVES AND USES

Provided herein include compositions, all related stereoisomers as well as pharmaceutically acceptable salts provided as simplified analogs of pateamine A, in which the analogs generally are devoid of..

Method for detecting cellular proliferative disorders

A novel T-type calcium channel (CACNA1G) is provided, as are polynucleotides encoding the same. CACNA1G has been implicated in cellular proliferative disorders. More specifically, it has been observed..

INDUCTION OF THYROID IODIDE-HANDLING GENE EXPRESSION IN HUMAN CANCERS

Dual suppression of the MAP kinase and PI3K/Akt pathways showed synergistic or greatly enhanced anti-melanoma cell effects, compared to suppression of a single pathway, including the inhibition of cel..

BRAIN ENDOTHELIAL CELL EXPRESSION PATTERN

PROBLEM TO BE SOLVED: To provide new techniques for isolating brain endothelial cells (ECs) and evaluating gene expression patterns to gain a better understanding of brain tumor angiogenesis. ; SOLUTI..

Biological pacemaker

Disclosed are methods and systems for modulating electrical behavior of cardiac cells. Preferred methods include administering a polynucleotide or cell-based composition that can modulate cardiac cont..

SECRETED AND CELL SURFACE GENES EXPRESSED IN BENIGN AND MALIGNANT COLORECTAL TUMORS

Serial analysis of gene expression (SAGE) was used to identify transcripts encoding secreted or cell-surface proteins that were expressed in benign and malignant tumors of the colorectum. A total of 2..

USE OF BIOMARKERS FOR DETECTING OVARIAN CANCER

The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measure..

BIOMARKER FOR IDENTIFICATION OF MELANOMA TUMOR CELLS

This invention relates to use of neuropilin-2 as a novel biomarker and therapeutic target for melanoma. The presence of neuropilin-2 can be used as a biomarker for diagnosing and detecting individuals..

DETECTION OF HEAD AND NECK CANCER USING HYPERMETHYLATED GENE DETECTION

Methods and kits for detection of a cell proliferative disorder, such as head and neck cancer are provided utilizing analysis of the methylation state of targeted genes or regulatory regions of genes ..

SITE-SPECIFIC MODIFICATION OF PROTEINS

Methods and compositions for site-specific modification of amino acids, peptides, polypeptides and proteins are disclosed.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF OCULAR OXIDATIVE STRESS AND RETINITIS PIGMENTOSA

Oxidative damage contributes to cone cell death in retinitis pigmentosa and death of rods, cones, and retinal pigmented epithelial (RPE) cells in ocular oxidative stress related diseases including age..

CIRCULATING MUTANT DNA TO ASSESS TUMOR DYNAMICS

DNA containing somatic mutations is highly tumor specific and thus, in theory, can provide optimum markers. However, the number of circulating mutant gene fragments is small compared to the number of ..

BIOMARKERS FOR MELANOMA

The present invention relates to methods of determining melanoma status in a subject. The invention also relates to kits for determining melanoma status in a subject. The invention further relates to ..

LATERAL FLOW DEVICE FOR DIAGNOSING MICROBIAL INFECTIONS

Fungal infections are difficult to diagnose. The most common filamentous fungal infection, aspergillosis, carries with it a high mortality. Culture of the organism is difficult and obtaining samples, ..

HYDROGEL-GRAFTED DEGRADABLE NERVE GUIDES

The present invention is directed to the compositions and methods of preparing hydrogel-grafted nerve guides for peripheral nerve regeneration. Particularly, the present invention describes the nerve ..

COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER USING TISSUE-SPECIFIC ONCOLYTIC ADENOVIRUSES

The present invention includes the use of a nucleic acid sequence encoding an shRNA to target RNA interference against a cellular factor where such use can enhance oncolytic adenovius replication. The..

ALBUMIN-BOUND PROTEIN/PEPTIDE COMPLEX AS A BIOMARKER FOR DISEASE

Methods and kits for diagnosis and prognosis using biomarkers comprising albumin-bound protein/peptide complex (ABPPC).

PRODRUG ACTIVATION IN CANCER CELLS USING MOLECULAR SWITCHES

The present invention features a novel protein engineering strategy by combining the domains of two independent proteins into a molecular switch. The invention features polypeptides comprising a prodr..

METHODS FOR PROMOTING FUSION AND REPROGRAMMING OF SOMATIC CELLS

The invention features methods for reprogramming somatic cells by treating the cells with one or more agents to induce de-differentiation, in particular by targeting demethylase and methyltransferase ..

PATHWAYS UNDERLYING PANCREATIC TUMORIGENESIS AND AN HEREDITARY PANCREATIC CANCER GENE

There are currently few therapeutic options for patients with pancreatic cancers and new insights into the pathogenesis of this lethal disease are urgently needed. To this end, we performed a comprehe..

METHODS AND KITS FOR IDENTIFICATION OF ANTI-EXCITOTOXIC COMPOUNDS

The instant invention provides methods and kits for screening for anti-excitotoxic compounds which increase the total amount of EAAT-I protein or the surface amount of EAAT-I protein.

TARGET AND METHOD FOR INHIBITION OF BACTERIAL RNA POLYMERASE

Target and method for inhibition of bacterial RNA polymerase disclosed are targets and methods for specific binding and inhibition of RNAP from bacterial species.

METHODS FOR OBTAINING BIOACTIVE COMPOUNDS FROM PHYTOPLANKTON

Phytoplankton represent a potential source of bioactive compounds. The present disclosure provides, inter alia, methods for identifying glycerolipids and apoptosis- inducing sphingosine-like lipids fr..

GRAFT POLYMERS FOR ENHANCED INTRACELLULAR DELIVERY OF ANTISENSE MOLECULES

Innovative graft polymers designed for the efficient delivery of antisense molecules into biological cells and for maintaining the biological activity of these molecules while in serum and other aqueo..

PREPARATION AND USES OF POLYARYLATES

The present invention is directed to polyarylates comprising repeating units having the structure: as well as their preparation and use as cell growth substrates

HIGH MOLECULAR WEIGHT POLYMERS, DEVICES AND METHOD FOR MAKING AND USING SAME

Anhydride polymers that release active or activatable agent(s) have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The polymers a..

LITHIUM STIMULATION OF CORD BLOOD STEM CELL PROLIFERATION AND GROWTH FACTOR PRODUCTION.

The present invention provides methods for expanding human umbilical cord blood stem cells and methods for stimulating growth factor production by cord blood stem cells using an in vitro cell culture ..

TOPOISOMERASE-TARGETING AGENTS

The invention provides compounds of formula I or formula II: wherein: the bond represented by

Transgenic plants expressing L3 delta proteins are resistant to trichothecene fungal toxins

Disclosed are specific mutants of L3 and transgenic plants that produce them. The plants exhibit increased resistance to fungal toxins that target ribosomal L3 protein. Also disclosed are transgenic p..

Non-cytotoxic PAP mutants

Disclosed are PAP mutants that are less toxic than wild type PAP and that exhibit depurination activity. Also disclosed are transgenic plants that produce the PAP mutants, and methods for preparing th..

Soybean Oil Based Oxygen Carrying Emulsion for Massive Blood Loss

VivaSure is a new treatment for shock from massive blood loss. It is based on soybean oil and is therefore biodegradable. It refills lost vascular volume, protects from free radicals, absorbs toxins a..

TOPOSIOMERASE INHIBITORS

The invention provides compounds of formula (I): wherein A, B, W, Y, Z, R1, R3 and R4 have any of the meanings defined in the specification and their salts. The invention also provides pharmaceutical ..

SWITCH-REGION: TARGET AND METHOD FOR INHIBITION OF BACTERIAL RNA POLYMERASE

The invention provides a target and methods for specific binding and inhibition of RNA polymerase from bacterial species. The invention provides methods for identifying agents that bind to a bacterial..

MEDIA CONDITIONING FOR IMPROVING GENE DELIVERY EFFICIENCY TO DIFFERENTIATING EMBRYONIC STEM CELLS

The present invention provides systems and methods for improving the efficiency of a transient gene delivery system to differentiating embryonic stem (ES) cells by serum starving the targeted cells fo..

HIGH-THROUGHPUT BIOMARKER SEGMENTATION UTILIZING HIERARCHICAL NORMALIZED CUTS

A method and apparatus for obtaining segmented images of the stained regions may comprise quantifying the extent of the presence of staining of a biomarker in an original image of a sample, which may ..

MONOMERS AND PHASE-SEPARATED BIOCOMPATIBLE POLYMER COMPOSITIONS PREPARED THEREFROM FOR MEDICAL USES

The invention relates to novel monomers of Formula (I) useful for preparation of phase-separated biocompatible polymers or polymer compositions. These polymers or polymer compositions may be bioresorb..

SYNTHESIS OF CYCLIC DIGUANOSINE MONOPHOSPHATE AND THIOPHOSPHATE ANALOGS THEREOF

The invention provides methods for the synthesis of cyclic dinucleotides and thiophosphate analogs thereof as well as a new family of analogs of cyclic diguanosine monophosphate that includes a series..

STEROSPECIFIC CARBONYL REDUCTASES

Stereospecific carbonyl reductases SCR1, SCR2, and SCR3 are described herein as are nucleotide sequences that encode these reductases. These stereospecific carbonyl reductases have anti-Prelog selecti..

OREGANO AND MINT ANTI-INFLAMMATORY COMPOSITIONS AND METHODS

The present invention relates to bioactivity-guided isolation and identification of bioactive compounds from oregano and mint plants, in particular, rosmarinic acid, oleanolic acid and ursolic acid, a..

Interspecific cornus hybrid designated KF 111-1

An advanced generation interspecific hybrid of Cornus kousa and C. florida that is distinguished by its exceptionally high vigor, attractive foliage, very floriferous display of white floral bracts, h..

BIORESORBABLE POLYMERS SYNTHESIZED FROM MONOMER ANALOGS OF NATURAL METABOLITES

New bioresorbable polymers are synthesized from monomer analogs of natural metabolites In particular, polymers are polymerized from analogs of amino acids that contribute advantageous synthesis, proce..

Disease Resistant Transgenic Plants

Provided are transgenic plants, seed and plant parts which display increased resistance to fungal disease or mycotoxin. Also provided are methods of making transgenic plants with increased resistance ..

Methods for Obtaining Bioactive Compounds from Phytoplankton

COMBINATION THERAPY TO IMPROVE DRUG EFFICIENCY

The instant invention provides methods for increasing drug bioavailability and/or preventing multi-drug resistance through inhibition of ABCG2 protein by caffeine or caffeine analogs.

MODULAR TRIPLE-HELICAL COLLAGEN-LIKE PRODUCTS

Recombinant bacterial triple-helical collagen-like proteins comprising two or more repetitive sequences of Gly-Xaa-Yaa yielding high-stability polymeric constructs without the need for post-translatio..

Cytokines and Genes Differentially Affected by TNF Blockers

The present invention is directed to cytokines and genes that are differentially affected by TNF blockers and the use of these genes and cytokines to help asses the TB risks of new immunosuppressive t..

Proteins, Nucleic Acids Encoding the Same, and Associated Methods of Use

Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to th..

NOVEL HUMAN LYSOSOMAL PROTEIN AND METHODS OF ITS USE

The gene associated and causative of classical late infantile neuronal ceroid lipofuscinosis (LINCL), CLN2, has been identified and characterized. The translation product of this gene is a novel prote..

Labeled Biomolecular Compositions and Methods for the Production and Uses Thereof

Disclosed herein is a set of E. coli single-protein production (SPP) technologies with protein NMR (SPP-NMR) for (i) using isotope-enriched membrane proteins produced with the SPP system in screening ..

TYPE I INTERFERON ANTAGONISTS

Disclosed in certain embodiments is a method of preparing a Type 1 interferon antagonist comprising modifying a Type 1 interferon at the site of interaction with the interferon receptor subunit IFNAR-..

NOVEL TOXIN-ANTITOXIN SYSTEM

Disclosed in certain embodiments is a method of inhibiting cell function comprising inducing the expression of a mRNA interferase that cleaves mRNA at GCU.

Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids

A method of sorting mixtures of nucleic acid strands comprising hybridizing the strands to an array of immobilized oligonucleotides, each of which includes a constant segment adjacent to a variable se..

Salivary Bioassay for Early Detection of Bone Loss

The present invention is directed to methods to detect and diagnose osteoporosis and periodontal disease using salivary biomarkers.

METHODS AND COMPOSITIONS FOR TREATING CANCER

The present invention provides methods of treating cancer using 2-amino-6-trifluoromethoxybenzothiazole (riluzole). In one aspect, the present invention provides methods of reducing cancer cell growth..

NOVEL MODIFICATION OF IMMUNOMODULATORY PROTEIN

Methods of inhibiting annexin I induced apoptosis by contacting a cell population containing a TRPM7/ChaK1 kinase with an effective amount of a composition containing an inhibitor for the kinase.

A METHOD OF USING AN EXTRACELLULAR MATRIX TO ENHANCE CELL TRANSPLANT SURVIVAL AND DIFFERENTIATION

Provided is a matrix for promoting survival and differentiation of cells transplanted thereon, comprising a base matrix and a cell-made matrix thereon. Methods and means for making and using same are ..

TELOMERASE REVERSE TRANSCRIPTASE VARIANT

The present invention relates to nucleic and amino acid sequences of a novel variant of the telomerase reverse transcriptase. More particularly, the present invention is directed to a novel variant of..

TARGETING BACTERIAL SUICIDE PATHWAYS FOR THE DEVELOPMENT OF NOVEL ANTIBIOTICS

The invention provides methods for identifying an agent which prevents or partially prevents an antitoxin from forming a complex with its cognate toxin, comprising contacting a potential agent with a ..

THE USE OF PROTEIN S FUSION FOR PROTEIN SOLUBILIZATION

The invention provides vectors containing a multiple cloning site comprising a PrS tag or a PrS2 tag from Myxococcus xanthus. Methods are provided for enhancing solubility of a target protein using Pr..

TARGETING TUMOR CELLS WITH CHEMOTHERAPEUTIC AGENTS CONJUGATED TO MATRIPTASE ANTIBODIES

The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expres..

IMAGING INDIVIDUAL mRNA MOLECULES USING MULTIPLE SINGLY LABELED PROBES

A method for probing a target sequence of messenger ribonucleic acid molecules (mRNA's) in a fixed, permeabilized cell, said target sequence including at least 30 non- overlapping probe binding region..

COMPOSITIONS COMPRISING MG29 NUCLEIC ACIDS, POLYPEPTIDES AND ASSOCIATED METHODS OF USE

Disclosed herein are compositions and methods for treatment of muscle dysfunction (including sarcopenia) and other diseases involving skeletal musle, including age-related muscle dysfunction. In addit..

ANTI-SENSE MICRORNA EXPRESSION VECTORS

The present invention relates to an alternative strategy for expressing the antisense sequence of a miRNA. This system allows for continuous production of the antisense sequence and subsequently compl..

Immunotherapy for Unresectable Pancreatic Cancer

The present invention provides a novel cancer immunotherapy comprising a vaccination schedule of both intratumoral and systemic injections followed by peripheral boost injection. The immunotherapy can..

Multiplex Screening for Pathogenic Hypertrophic Cardiomyopathy Mutations

This invention relates to a new method of screening for hypertrophic cardiomyopathy. In certain embodiments, the invention comprises a method of screening for hypertrophic cardiomyopathy comprising de..

Cold Shock Protein Compositions and Methods and Kits for the Use Thereof

The present invention provides cold shock protein-containing compositions for improved DNA synthesis reactions with improved reactivity, methods for synthesizing DNA using such compositions, kits for ..

Compositions and methods for enzymatic detachment of bacterial and fungal biofilms

Isolated nucleic acid sequences and amino acid sequences for soluble -N-acetylglucosaminidase or active fragments or variants thereof which promote detachment of bacterial cells from a biofilm are pro..

TISSUE ENGINEERED FIBROCARTILAGE REPLACEMENT

Fibrocartilage implants characterized by circumferential fiber networks embedded in arcuate or torroidal scaffolds with orthogonal fiber networks embedded therein to prevent separation of the circumfe..

Chemoprevention of Colorectal Cancer by Mesalamine/Sulfasalazine

A method for preventing or treating colorectal cancer in a patient possessing human tropomyocin isoform TC22 is presented. Also presented is a method for evaluating TC22 expression reduction activity ..

PROTEINS EXPRESSED BY MYCOBACTERIUM TUBERCULOSIS AND NOT BY BCG AND THEIR USE AS VACCINES

The present invention is directed to proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as vaccines.

STRATEGY FOR HOMO- OR HETERO-DIMERIZATION OF VARIOUS PROTEINS IN SOLUTION AND IN CELL

The present invention describes a chimeric polypeptide comprising a first portion comprising a receptor domain, wherein the receptor domain comprises an intracellular region and a transmembrane region..

NOVEL COMPOUNDS FOR INHIBITING EEF2 KINASE ACTIVITY

The present invention discloses novel compounds for inhibiting eEF2 kinase and methods of use thereof.

E2F AS A TARGET FOR TREATMENT OF HORMONE REFRACTORY PROSTATE CANCER

The instant invention provides amino acid sequences competing with E2F for DNA binding. Methods of using said amino acid sequences for treatment of hormone-refractory prostate cancer are also provided..

STRUCTURE OF A PROTEIN PHOSPHATASE 2A HOLOENZYME: INSIGHTS INTO TAU DEPHOSPHORYLATION

Embodiments of the present invention relate to crystals and atomic coordinates for PP2A, as well as methods for using these atomic coordinates to prepare modulators of PP2A and inhibitors prepared usi..

DEMETHYLATION AND INACTIVATION OF PROTEIN PHOSPHATASE 2A

Embodiments of the present invention relate to atomic coordinates for PME-1 alone or in complex with PP2A, as well as methods for using these atomic coordinates to prepare inhibitors of PME-1 and/or P..

NANOPARTICLES FOR PHOTODYNAMIC THERAPY

Embodiments of the invention include nanoparticulate products of a flash nanoprecipitation process, the products comprising, in combination, pre-formed nanoparticles having properties of an upconversi..

IDENTIFICATION OF BACTERIAL AUTOINDUCER AND USE IN TREATING BACTERIAL PATHOGENICITY

A bacterial autoinducer, CAI-I, was purified and its structure identified. Methods for synthesis of the autoinducer and its analogues were elucidated. Methods of using the autoinducer or its analogues..

NANO-PARTICLE SURFACE MODIFICATION

Oxide, oxysulfide, halide or phosphate host particles with a self-assembled organo- phosphonate monolayer covalently bonded thereto. Methods for coating the host particles and use of rare earth ion-do..

MODULATORS OF PROTEIN PHOSPHATASE 2A AND PP2A METHYL ESTERASE

The disclosure relates to modulation of protein phosphorylation, including information derived from the structures and activities of the proteins designated protein phosphatase 2A (PP2A) and PP2A meth..

Nanochannel arrays and their preparation and use for high throughput macromolecular analysis

Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecu..

IAP BINDING COMPOUNDS

Compounds that bind cellular IAPs (inhibitor of apoptosis proteins) are disclosed. The compounds are mimetics of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABOLO, Hid, Grim an..

INHIBITORS OF MTOR KINASE AS ANTI-VIRAL AGENTS

The present invention provides methods and compositions for treating or preventing viral infections using modulators of host cell enzymes relating to mTOR. The invention also provides methods and comp..

SiRNA PHOSPHOLIPID CONJUGATE

siRNA-conjugated liposomes and micelles, methods of making such conjugates, and methods of using such conjugates, such as for the delivery of siRNA to cells to reduce expression of target polypeptides..

STEROIDAL ANTI-HORMONE HYBRIDS

Disclosed are novel compounds and compositions for inhibition of androgen and estrogen receptor signaling, methods for inhibiting androgen signaling, methods for inhibiting estrogen signaling, methods..

MIXED MICELLES INCLUDING AMPHIPATHIC CONJUGATES OF RNA AGENTS, AND USES THEREOF

Disclosed are improved pharmaceutical formulations for the delivery of RNA interference agents, such as antisense RNA, micro-RNA and siRNA. The formulations employ mixed micelles including amphipathic..

METHOD OF PREPARING ADENOSINE-RESISTANT ANTI-TUMOR T LYMPHOCYTES FOR ADOPTIVE IMMUNOTHERAPY

In the past, adoptive immunotherapy often failed because the transferred immune cells were inactive in vivo. This disclosure provides a method of producing immune cells that are highly active in vivo...

IMAGING NEUROLEPTIC COMPOUNDS

A method for identifying typical and atypical antipsychotics based on their ability to reduce neuronal/glial activity in specific brain regions upon dopaminergic neurotransmission is disclosed.

COLLAGEN FIBRILLAR CONSTRUCTION

Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engine..

POLYCYCLIC COMPOUNDS FOR USE IN TREATING OCULAR NEURODEGENERATIVE DISEASES

Described herein are various compounds for treatment of ocular neurodegenerative diseases, including but not limited to glaucoma and diabetic retinopathy. The compounds described herein can act to att..

METHODS OF TREATING FUNGAL INFECTIONS

Methods of identifying compounds that potentiate the activity of antifungal agents, potentiators identified by these methods, and methods of using potentiators are disclosed.

METHODS OF TARGETING CELLS FOR DIAGNOSIS AND THERAPY

Methods of making bispecific binding complexes and nanopolymers coupled to detection and/or therapeutic agents are disclosed. Also disclosed are methods of using such bispecific binding complexes and ..

SELF-ASSEMBLING MICELLE-LIKE NANOPARTICLES FOR SYSTEMIC GENE DELIVERY.

Nanoparticles containing nucleic acid and suitable for use as in vivo delivery agents for nucleic acids are provided. The nanoparticles use a covalent conjugate of a polycation such as polyethylenimin..

MODULATORS OF NUCLEAR RECEPTOR CO-REGULATORY PROTEIN BINDING

Biomarkers for Diabetes, Obesity, and/or Hypertension

Methods of identifying subjects having, or at risk of developing, diabetes, obesity, and/or hypertension are disclosed, as well as methods of identifying biomarkers for diabetes, obesity, and/or hyper..

Methods and Compounds for Modulating Cannabinoid Activity

Disclosed are compounds and compositions that inhibit the action of monoacylglycerol lipase (MGL) and fatty acid amide hydrolase (FAAH), methods of inhibiting MGL and FAAH, methods of modulating canna..

T CELL RECEPTOR-DEFICIENT T CELL COMPOSITIONS

The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one e..

NUTRACEUTICAL COMPOSITION AND METHODS FOR PREVENTING OR TREATING MULTIPLE SCLEROSIS

The present invention embraces nutraceutical compositions containing isolated Bacteroides fragilis capsular polysaccharide A for use in methods of preventing or treating multiple sclerosis.

MICRORNA-10 ANTAGONISTS AND MICRORNA-10 TARGETS FOR USE IN THE TREATMENT OF A GLIOMA

The present invention embraces microRNA-antagonists and activators of homeobox D10 protein; Zinc finger, MYND domain containing 11 protein; or RB1-inducible coiled-coil 1 protein for use in decreasing..

ATTENUATED URACIL AUXOTROPH OF AN APICOMPLEXAN AND USE THEREOF

Uracil auxotroph mutants of apicomplexans are provided which lack a functional carbamoyl phosphate synthase II (CPSII) enzyme. Also provided are T. gondii autoxtroph mutants which express exogenous an..

Compositions and methods for inhibiting the synthesis or expression of MMP-1

The present invention relates to the specific inhibition of matrix metalloproteinase 1 (MMP-1) using agents which inhibit the synthesis or expression of MMP-1. Such agents are useful for suppressing i..

Methods for diagnosing and treating neuroendocrine cancer

The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods fo..

CDDO-COMPOUNDS AND COMBINATION THERAPIES THEREOF

CDDO-compounds in combination with other chemotherapeutic agents induce and potentiate cytotoxicity and apoptosis in cancer cell. One class of chemotherapeutic agents include retinoids. Cancer therapi..

COMPOSITIONS AND METHODS FOR INHIBITING THE INTERACTION BETWEEN CFTR AND CAL

The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides..

SELECTION OF CELLULOLYTIC MICROBES WITH HIGH GROWTH RATES

Methods for obtaining cellulolytic microbes with high growth rates are disclosed. For example, C. thermocellum colonies with growth rates higher than 0.17 hr " 1 have been obtained by the present meth..

COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF PANCREATIC DUCTAL CANCER

The present invention includes compositions and methods for diagnosing and treating pancreatic cancer. These compositions and methods are based on the finding that 14-3-3s protein is secreted from pan..

MOLECULAR SIGNATURES FOR DIAGNOSING SCLERODERMA

The present invention features methods for classifying, determining severity, and predicting clinical endpoints of scleroderma based upon the expression of selected biomarker genes.

PREVENTION OR TREATMENT OF IMMUNE-RELEVANT DISEASE BY MODIFICATION OF MICROFLORAL POPULATIONS

The present invention is a method for preventing or treating an immune -relevant disease by modulating commensal microbiota populations via antibiotics, exogenous microbiota and/or probiotics.

BIOACTIVE MOLECULES PRODUCED BY PROBIOTIC BACTERIA AND METHODS FOR ISOLATING AND USING THE SAME

The present invention is a method for isolating bioactive molecules secreted by probiotic bacteria such as Lactobacillus rhamnosus, and methods for using such bioactive molecules to decrease replicati..

Bis-carbazole DNA intercalating agents for antitumor therapy

The present invention is a DNA intercalating agent represented by the structure Y-Z-Y, wherein Y is an anti-tumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, containing at ..

MICRORNA BIOMARKERS FOR HUMAN BREAST AND LUNG CANCER

The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.

METHOD FOR IDENTIFYING AN AGENT THAT INHIBITS CANDIDA ALBICANS -MEDIATED HOST CELL DIFFERENTIATION

The present invention features a method for identifying an agent that inhibits Candida albicans- mediated differentiation of keratinocytes. Agents identified by the screening assay of the invention fi..

CAVEOLIN 1-REPORTER PROTEIN KNOCK-IN MOUSE

The present invention embraces a transgenic mouse whose genome harbors a nucleic acid molecule encoding caveolin-1 fused in-frame with a reporter. To control expression of the Cavl-reporter, the nucle..

Microrna-21 antagonists and its target PDCD4 for use in the treatment of a glioma

The present invention embraces microRNA-21 antagonists and activators of Programmed Cell Death 4 for use in decreasing glial tumor cell proliferation and treating glioma.

CELL CULTURE HYDROGEL WITH pH INDICATOR

The invention provides devices, compositions and methods for maintaining conditions in a cell culture and for measurement of conditions in the cell culture. In particular, the invention provides hydro..

COMPOSITIONS AND METHODS FOR TREATING CANCER WITH DACARBAZINE NANOEMULSIONS

A uniform microfluidized nanoemulsion is disclosed containing an anti-cancer agent, such as dacarbazine. The microfluidized nanoemulsion improves the combination's cell membrane permeability by at lea..

SYNERGETIC FUNCTIONALIZED SPIRAL-IN-TUBULAR BONE SCAFFOLDS

An integrated scaffold for bone tissue engineering has a tubular outer shell and a spiral scaffold made of a porous sheet. The spiral scaffold is formed such that the porous sheet defines a series of ..

STRUCTURAL/BIOLOGICAL IMPLANT SYSTEM

A structural/biological implant and method of use. The implant being utilized as a single or multiple staged system that is designed to encourage new alveolar bone growth with or without the need to o..

BIOSENSOR FOR CONTINUOUS MONITORING OF METABOLITES AND PROTEINS AND METHODS OF MANUFACTURE THEREOF

A biosensor comprises a substrate; a reference electrode; a working electrode; a counter electrode; and a plurality of permeability adjusting spacers. The reference electrode, the working electrode an..

METHODS OF INHIBITING VASCULAR PERMEABILITY AND APOPTOSIS

Agonists of vascular endothelial sphingosine-1-phosphate receptors are described. Compounds such as FTY720 can be phosphorylated by sphingosine kinase-2 into the phosphorylated forms which serve as sp..

DIFFERENTIATION OF HUMAN EMBRYONIC AND INDUCED PLURIPOTENT STEM CELLS

The invention relates to culture systems, methods, and conditions that allow pluripotent undifferentiated hESCs or iPSCs to progressively and uniformly differentiate into cells of the chondrogenic lin..

FLUORINATED LIPIDS AND METHODS OF USE

The invention provides methods and compounds for delivering agents to cells. The compounds can include a fluorinated lipid, a linker, and an agent for delivery to a cell.

POLYMERIC MICROSPHERES

The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell with ..

METHODS AND COMPOSITIONS FOR MODULATING MEMBRANE POTENTIAL TO INFLUENCE CELL BEHAVIOR

The present invention provides methods for controlling proliferation, differentiation, and/or migration of cells by modulating membrane potential through an endogenously expressed channel protein. The..

MEASUREMENT OF BIOLOGICAL TARGETS

An integrated imaging system, e.g., a microsystem, for detecting activity of a biological target, for example, in response to a stimulus, includes an array of pixels arranged on a substrate, each pixe..

SMAD PROTEINS CONTROL DROSHA-MEDIATED MIRNA MATURATION

The invention, in some aspects, relates to compositions and methods useful for modulating expression of miRNAs that are regulated by the TGF-ss/BMP signaling pathway. In some aspects, the invention re..

ANTI-APOPTOTIC AGENTS AND USES THEREOF

The invention generally relates to the use of parasite-derived neurotrophic factor (PDNF), or a fragment of PDNF, to reduce cell apoptosis. The PDNF or PDNF fragment is provided in the cytoplasm of a ..

SILK BIOMATERIAL AND METHOD OF USE THEREOF

The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such..

CATIONIC CONTRAST AGENTS AND METHODS OF USE THEREOF

The present invention provides compounds useful as contrast agents, such as for the CT imaging of cartilage tissue. The contrast agents are generally iodinated organic molecules that are positively ch..

ENGINEERED ENZYMATICALLY ACTIVE BACTERIOPHAGE AND METHODS FOR DISPERSING BIOFILMS

The present invention is directed to engineered enzymatically active bacteriophages that are both capable of killing the bacteria by lysis and dispersing the bacterial biofilm because they have been a..

NANOCHANNEL-BASED SENSOR SYSTEM FOR USE IN DETECTING CHEMICAL OR BIOLOGICAL SPECIES

A sensor system for detecting a chemical or biological species includes a sensing element and a bias and measurement circuit. The sensing element includes nanochannels, each having an outer surface fu..

ALIEN SEQUENCES

The present invention provides sequences and reagents for preparing microarrays with internal controls. Specifically, the present invention defines and provides sequences that are not present in the h..

METHOD FOR BACTERIAL LYSIS

The present invention is directed to a microfluidic device for lysis of cells, such as bacteria and microorganisms. In particular, the present invention relates to microfluidic devices and methods of ..

HIGH MAGNIFICATION SPECTRAL REFLECTANCE BIOSENSING WITH DISCRETE LIGHT SOURCES

A spectral reflectance imaging device for detecting biomolecular targets includes an illumination source that illuminates a substrate with a plurality of separate wavelengths of incoherent light. The ..

BACTERIOPHAGES EXPRESSING ANTIMICROBIAL PEPTIDES AND USES THEREOF

The present invention is generally related to engineered bacteriophages expressing antimicrobial peptides or lytic enymes or fragments thereof for targeting a broad spectum of bacterial hosts, and for..

NUCLEIC ACID SUPPORTED PROTEIN COMPLEMENTATION

The present invention is directed to novel methods for in vitro and in vivo detection of target nucleic acid molecules, including DNA and RNA targets, as well as nucleic acid analogues. The present in..

ISOLATION OF RNA

Disclosed herein are methods for purification of RNA from a sample. The method involves preparing the sample in a solution of lysis buffer, depositing it into a first end of a lysis straw such that th..

SEQUENCE PRESERVED DNA CONVERSION

Described herein are inexpensive high throughput methods to convert a target single stranded DNA (ssDNA) such that each nucleotide (or base) adenine (A), thymine (T), guanine (G) and cytosine (C) is c..

NUCLEIC ACID CLONING

The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be eas..

BACTERIOPHAGES EXPRESSING AMYLOID PEPTIDES AND USES THEREOF

The present invention generally relates to engineered bacteriophages which express amyloid peptides for the modulation (e.g. increase or decrease) of protein aggregates and amyloid formation. In some ..

BIOREACTIVE AGENTS

This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, ..

ANTIMICROBIAL IONIC LIQUIDS

Certain aspects of the present invention relate to compositions, formulations, and use of ionic liquids as antimicrobial agent (e.g. as antibacterial and/or antifungal agents). In certain embodiments,..

MELANOMA BIOMARKER AND METHODS OF USES

The present invention relates to the use of TROY, also called tumor necrosis factor receptor superfamily, member 19 (TNFRSF19) also called toxicity and JNK inducer (TAJ), in diagnosis and therapy of n..

LABEL-FREE SENSING OF PNA-DNA COMPLEXES USING NANOPORES

Embodiments disclosed herein relate to a method of detecting specific DNA sequences and the application of this method in the detection of pathogens, viruses, drug-resistant pathogens, genomic variati..

CHROMOSOME THERAPY

The present invention features compositions and methods for introducing, into cells, nucleic acids whose expression results in chromosomal silencing. The nucleic acids are targeted to specific chromos..

NUCLEIC ACID SILENCING AGENT-PROTEIN CONJUGATES AND USE THEREOF FOR TREATING HCV-RELATED DISORDERS

A method of using a complex or a molecule comprising a targeting moiety to deliver a second molecule effectively to HCV or to a cell being infected or having the potential to be infected by HCV, resul..

TRYPTOPHAN AS A FUNCTIONAL REPLACEMENT FOR ADP-RIBOSE-ARGININE IN RECOMBINANT PROTEINS

A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one ..

STABILIZED LIPOSOME COMPOSITIONS AND RELATED METHODS OF USE

Liposome compositions and related methods of preparation which can comprise one or a plurality of biopolymer components.

MEASURING TISSUE OXYGENATION

Methods and systems for calculating tissue oxygenation, e.g., oxygen saturation, in a target tissue are disclosed. In some embodiments, the methods include: (a) directing incident radiation to a targe..

TOLL-LIKE RECEPTOR-BASED BIOSENSORS

Compositions and methods for detecting Toll-like receptor binding to ligands and test compounds are disclosed herein.

INTERLEUKIN 6 AND TUMOR NECROSIS FACTOR ALPHA AS BIOMARKERS OF JNK INHIBITION

Biomarkers for JNK inhibition are described that can be used for monitoring effectiveness of JNK inhibitors and monitoring treatment with JNK inhibitors.

ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS

Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are de..

METHODS AND COMPOSITIONS TO REDUCE OXIDATIVE STRESS

The invention relates to therapeutic applications for compositions that reduce the level of oxidative stress on cells in vivo or in vitro. The invention describes methods for improving the therapeutic..

Toll-Like Receptor 9 Modulators

TLR9 is localized to endoplasmic reticulum and upon stimulation with a TLR9 ligand, is transported to a tubular lysosomal compartment as is CpG-DNA. Furthermore, it is shown that TLR9 and CpG-DNA dire..

METHODS FOR MICROBIAL PRODUCTION OF TERPENOIDS

The invention relates to recombinant expression of terpenoid synthase enzymes and geranylgeranyl diphosphate synthase (GGPPS) enzymes in cells and the production of diterpenoids.

Methods and compositions for enhancing the efficacy and specificity of RNAi

A method of enhancing the efficacy of an siRNA duplex, or promoting entry of an antisense strand of an siRNA duplex into a RISC complex, the siRNA duplex comprising the antisense strand and a compleme..

MULTIPURPOSE MICROFLUIDIC DEVICE FOR MIMICKING A MICROENVIRONMENT WITHIN A TUMOR

The present application relates generally to a novel microfluidic device for the in it propagation of neoplastic cellagregates under conditions that mimic the physiological microenvironment found in t..

COMPLEMENT FACTOR H-BASED ASSAYS FOR SERUM BACTERICIDAL ACTIVITY AGAINST NEISSERIA MENINGITIDIS

Assays for detection of bactericidal anti-Neisserial antibodies using a factor H polypeptide having a human amino acid sequence that mediates binding to Neisserial factor H binding protein (fhBp) are ..

STAPHYLOCOCCUS DETECTION ASSAYS

Provided herein are methods, kits, and compositions related to nucleic acid detection that allow the detection and discrimination of various Staphylococcus species and types. In particular, provided h..

NUCLEIC ACID PROCESSING METHODS, KITS AND DEVICES

Biological samples containing nucleic acids, RNA and DNA, are freed from bound proteins by incubation with a chaotropic agent such as a guanidium salt, and the mixture is readied for further processin..

PRIMERS, PROBES AND METHODS FOR NUCLEIC ACID AMPLIFICATION

Homogenous detection during or following PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled primers and probes, improves reproducibility and quantif..

REAGENTS AND METHODS FOR PCR

Modified double-stranded oligonucleotides that have terminal regions on each of their strands, that have a hybrid length of 6-50 nucleotides long, that have a melting temperature Tm of at least 32 DEG..

Reagents and methods for improving reproducibility and reducing mispriming in PCR amplification

An additive for preventing mispriming in polymerase chain reaction (PCR) amplifications and assays comprising a hairpin oligonucleotide having a stem duplex greater than six nucleotides in length and ..

METHODS OF USING MIR-199A AS A MARKER AND SEQUENCES OF MIR-199A AS A THERAPEUTIC FOR CANCER

The invention relates to methods of measuring the level of expression of differentially expressed microRNAs (miRNAs), such as for example hsa-mir-199a, in a cancer cell as an indicator of the level of..

USE OF THE COMBINATION OF PHY906 AND A TYROSINE KINASE INHIBITOR AS A CANCER TREATMENT REGIMEN

This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of ..

ROCK INHIBITORS AND USES THEREOF

The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are compounds that inh..

METHODS AND COMPOSITIONS RELATED TO RIBOSWITCHES THAT CONTROL ALTERNATIVE SPLICING.

Disclosed are methods and compositions related to riboswitches that control alternative splicing.

AAV-MEDIATED DELIVERY OF DNA TO CELLS OF NERVOUS SYSTEM

PROBLEM TO BE SOLVED: To provide a method of delivering a DNA exogenous to both an adeno-associated virus (AAV) and a target cell of the mammalian nervous system. ; SOLUTION: The method includes the s..

A SNP MARKER OF BREAST AND OVARIAN CANCER RISK

The invention provides methods for predicting an increased risk or probability of developing breast or ovarian cancer in a patient based upon the patient's KRAS-Variant and BRCA status.

TISSUE ENGINEERING OF LUNG

The present invention relates to compositions comprising a decellularized tissue. The present invention also provides an engineered three dimensional lung tissue exhibiting characteristics of a natura..

NOVEL MARKERS FOR DETECTION OF COMPLICATIONS RESULTING FROM IN UTERO ENCOUNTERS

Described herein are biomarkers, such as protein biomarkers, which are diagnostic of and predictive for complications that result from an in utero encounter, such as an infection by the fetus, that ca..

COMPOSITIONS AND METHODS OF USE OF AN ONCOLYTIC VESICULAR STOMATITIS VIRUS

Oncolytic VSV viruses have been developed as a strategy for combating cancer. The present invention includes mutant VSV that have one or more mutations in the nucleic acid sequence encoding the viral ..

DETECTION, ISOLATION AND USES OF RENALASE (MONOAMINE OXIDASE C)

The present invention provides for the identification, isolation and uses of mammalian Monoamine Oxidase C (MAO-C), also known as renalase.

Identification of cancer protein biomarkers using proteomic techniques

The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discrimin..

Semaphorin 7A Plays a Critical Role in TGF-Beta1-Induced Pulmonary Fibrosis and Alveolar Destruction

The present invention provides methods of treating a subject diagnosed with, or at risk for developing, pathogenic fibrosis, particularly pulmonary fibrosis. The method of the invention comprises admi..

INHIBITORS OF RECEPTOR TYROSINE KINASES AND METHODS OF USE THEREOF.

The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V rece..

METHODS AND COMPOSITIONS RELATED TO RIBOSWITCHES THAT CONTROL ALTERNATIVE SPLICING AND RNA PROCESSING.

Disclosed are methods and compositions related to riboswitches that control alternative splicing.

RIBOSWITCHES AND METHODS AND COMPOSITIONS FOR USE OF AND WITH RIBOSWITCHES.

Riboswitches are targets for antibiotics and other small molecule therapies. Riboswitches and portions thereof can be used to regulate the expression or function of RNA molecules and other elements an..

METHYLATION BIOMARKERS AND METHODS OF USE

Disclosed are methods and compositions of assessing one or more statuses of a subject. Also disclosed are methods and compositions of identifying status biomarkers associated with a status of a subjec..

IDENTIFICATION OF CANCER PROTEIN BIOMARKER USING PROTEOME TECHNIQUE

PROBLEM TO BE SOLVED: To provide a testing method capable of being used in order to diagnose the cancer of an ovary in an initial stage or an advanced stage. ; SOLUTION: There are disclosed a method f..

INSTRUMENTS, METHODS AND SYSTEMS FOR HARVESTING AND IMPLANTING CARTILAGE MATERIALS

The present disclosure provides instruments and systems for accessing and removing hyaline cartilage from desired donor sites. The present disclosure also provides instruments/systems for implantation..

SINGLE NUCLEOTIDE POLYMORPHISMS IN BRCA1 AND CANCER RISK

The invention provides methods for identifying mutations, such as single nucleotide polymorphisms (SNPs), within breast and ovarian cancer associated genes that modify the binding efficacy of micro RN..

JNK3 MODULATOR AND METHOD FOR USING THE SAME

PROBLEM TO BE SOLVED: To provide a method for screening a molecule and compound reducing the expression or activity of the c-Jun NH2terminal kinase (JNK) group of a MAP kinase. ; SOLUTION: Th..

COMPOSITIONS AND METHODS FOR INHIBITING INFLAMMATION FROM AND REJECTION OF BIOMATERIALS AND OTHER METHODS

The present invention relates, inter alia, to methods and compositions for regulating the host response to biomaterials, including inhibiting inflammation from and rejection of biomaterials using sali..

METHODS OF REGULATING RENALASE (MONOAMINE OXIDASE C)

The present invention provides methods of using Monoamine Oxidase C (MAO-C), also known as renalase, as a therapeutic protein in its active and inactive forms. Administering inactive renalase protein ..

Regulation of oncogenes by microRNAs

Naturally occurring miRNAs that regulate human oncogenes and methods of use thereof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not ..

IMMUNIZATION TO REDUCE NEUROTOXICITY DURING TREATMENT WITH CYTOLYTIC VIRUSES

Methods for protecting the brain and other tissues from virus- associated toxicity are provided. Patients are treated with a first immunizing virus prior to administration of a second, therapeutic cyt..

TOLL-LIKE RECEPTOR 4 DEFICIENCY AND DOWNSTREAM EFFECTORS CAUSE PULMONARY EMPHYSEMA

The present invention provides compositions and methods for the detection, treatment, and prevention of emphysema/COPD. Compositions of the present invention comprise TLR4 activators, Nox3 inhibitors,..

Targeting TGF-beta as a Therapy for Alzheimer's Disease

The invention includes compositions and methods for enhancing peripheral macrophage A[beta] phagocytosis activity. The invention includes inhibiting a component of TGF-[beta] signaling pathway in peri..

Systems, Devices and Methods For Cartilage and Bone Grafting

Disclosed are systems, methods, devices and products to identify suitable donor sites for harvesting bone-cartilage grafts and to implant such bone-cartilage grafts. In some embodiments, a method incl..

SMALL MOLECULE INHIBITORS OF AUTOTAXIN AND METHODS OF USE

Autotaxin (ATX) is a prometastatic enzyme initially isolated from the conditioned media of human melanoma cells that stimulates a myriad of biological activities including angiogenesis and the promoti..

METHOD FOR THE DETERMINATION OF PHOSPHOLIPIDS IN AMNIOTIC FLUID SAMPLES

The present invention refers to a fast method for the determination of phospholipids in amniotic fluid samples by HPTLC (high performance thin layer chromatography). This innovative method presents hi..

BRAIDED CORRUGATED TEXTILE VASCULAR PROSTHESIS AND PROCESS OF PRODUCING SAME

The present invention relates to a braided corrugated vascular prosthesis with a textile structure consisting of at least two types of biocompatible fibres, of which one is absorbable by the human bod..

COMPOSITIONS COMPRISING ANTIOXIDANT AND MITOPROTECTIVE FLAVONOIDS WITH NEUROPROTECTIVE PROPERTIES

The present invention discloses compositions comprising phenolic compounds present in plant extracts with therapeutic activity against neuronal excitotoxicity, oxidative stress and mitochondrial dysfu..

ESTÉRASE THERMOPHILE DE THERMUS THERMOPHILUS

The invention relates to a thermophilic protein with esterase activity. Said protein, of the Thermus thermophilus organism, is expressed in recombinant yeasts and bacteria, in particular E.coli, K.lac..

Biphasic calcium phosphate and method for obtaining same from fish bones

The present invention relates to a biphasic calcium phosphate comprising between 5 and 40% by weight of beta-tricalcium phosphate; between 0.1 and 0.6% by weight of Mg; between 0.2 and 0.8% by weight ..

USE OF A CASEIN-DERIVED PEPTIDE AND COMPOSITIONS THEREOF AS ANTIHYPERTENSIVE

Use of a casein-derived peptide with antioxidant and ACE-inhibitory activity in vitro and antihypertensive activity in mammals, and compositions thereof. This peptide may be use as active ingredient i..

Trangenic mice used as model for human pathologies originating from stem cells

Transgenic non-human mammals that reproduce the human pathology that is of stem cell origin, for example, chromosomal anomalies associated with chronic myeloid leukaemia, B-cell acute lymphoblastic le..

CELL-CULTURE FLOW BIOREACTOR

Cell-culture flow bioreactor that comprises an incubator (1), the receptacle (14) of which, to which access is gained via a hermetically sealed door (13), is defined by thermally insulating walls, and..

LIPOSOMES COVERED WITH THE EXTRACELLULAR DOMAIN OF THE APO2L/TRAIL PROTEIN

The invention relates to the field of biotechnology and medicine. The invention specifically relates to a compound comprising a liposome covered or decorated at least with the extracellular domain of ..

SMART PACKAGING FOR DETECTING MICROORGANISMS

The present invention relates to novel smart packaging, designed using a novel material comprising a partially polar adsorbent solid base impregnated with a solution of vanillin, which allows the grow..

VECTORS AND USES OF THE MBOUMAR TRANSPOSON

The invention relates to the recombinant production of a naturally active transposase of Messor bouvieri, transposon Mboumar-derived genetic constructions necessary for transgenesis and mutagenesis, a..

NOVEL AMPEROMETRIC BIOSENSOR, PRODUCTION METHOD THEREFOR AND USE OF SAME

The invention relates to a novel amperometric biosensor, the production method therefor and use of same. The invention is based on a combination of the laccase enzyme and sonogel-carbon materials. The..

METHOD FOR ENHANCING THE EFFECTIVENESS OF BACTERIAL STRAINS

A method for enhancing the pathogenicity of bacterial strains of the genus Bacillus, which comprises exposing the strain to temperatures below ambient temperature or other situations of stress, a comp..

SINGLE-LABELLING AGENTS BASED ON VINYL SULPHONE

The invention relates to labelling agents containing a compound with a labelled molecule and a vinyl sulphone group. The invention also relates to the compounds, the method for obtaining same and the ..

COMPOUND OF SILICA-VINYLSULPHONE, SYNTHESIS AND USES OF THE SAME

Compound which comprises a medium of silica functionalized with vinylsulphone groups. In addition, the invention describes the method for production thereof and uses thereof as an immobilizer of biomo..

POROUS BIOTIN CARRIER, AND ASSOCIATED PRODUCTION METHODS AND USES

The invention relates to a compound comprising biotin joined to a porous carrier by means of a linker containing the group 1, 2, 3-triazole. The invention also relates to the method for obtaining said..

STRAIN CECT 7462 OF BACILLUS PUMILUS AND A METHOD FOR INCREASING THE ENTOMOPATHOGENIC EFFECTS THEREOF

The invention relates to a novel bacterial strain of Bacillus pumilus (CECT 7462 or B. pumilus TCC). Said strain can be treated with exposure to low temperatures in order to increase the entomopathoge..

ANTIBODIES FOR TREATING CANCER

The invention relates to the use of an antibody or a fragment thereof, specific against substance P, for the manufacture of a medicament for therapeutic treatment of a cancer expressing NK1 receptor a..

GENOME SEQUENCES OF PRIMERS AND A PROBE FOR THE QUANTIFICATION OF PORCINE ADENOVIRUSES (PAdV)

The invention relates to a sensitive test for the detection of porcine adenoviruses in environmental samples, water and food. Specifically, the invention relates to a quantitative tool intended for th..

CIS BICYCLIC COMPLEXES OF PLATINUM (II) HAVING ANTICANCER ACTIVITY

The invention relates to compounds having formula (I), wherein: the broken line represents a single or double bond; X is N, O, S, or -(CH2)n-; n is an integer between 1 and 3; R1 is a radical selected..

NOVEL CHEMOTHERAPEUTIC AGENTS FOR CANCER TREATMENT

The invention relates to compounds having formula (15), shown below, in which R1 is H or I, R2 is a radical selected from (C1-C16)-alkyl, phenyl and benzyl, R3 is a (C2-C4)-alkyl group and the configu..

NOVEL CHEMOTHERAPEUTIC AGENTS FOR TREATING CANCER

The compounds of formula (I) where: R1, R2, R3 and R4 are independently H, or a radical selected from hydroxyl; -OR; and -OCOR; where R is a radical selected from (C1-C4)-alkyl, phenyl, -(CH2)n-phenyl..

CRANIAL IMPLANT

An Implant, such as a cranial implant (3), for attachment to a defect (2) in a bone structure (1) having an edge (4) is described. The implant comprises a direction of extension and a rim (5) extendin..

USE OF GLYCOSAMINOGLYCAN FOR RESTORING GLYCOCALYX

The invention is directed to the use of glycosaminoglycans for restoring glycocalyx functions or preventing glycocalyx damage. The effectiveness of glycosaminoglycans is directed in all pathologies wh..

In vitro method for predicting whether a compound is genotoxic in vivo.

The invention is in the field of genomics and it provides an in vitro method for predicting whether a compound is genotoxic in vivo. It provides a method that employs the analysis of expression profil..

HOMOGENEOUS, INTRINSIC RADIOPAQUE EMBOLIC PARTICLES

The invention is directed to embolic material comprising spherical, homogeneous and substantially non-porous radiopaque polymer particles based on at least one hydrophilic monomer and at least one rad..

Method for determining the primary site of cup

The invention relates to a method for the classification of cancer using a specific multi-class tumor classifier comprising specific sets of genes for the interpretation of expression data obtained fr..

PEPTIDE LIGANDS FOR TARGETING TO THE BLOOD-BRAIN BARRIER

The present invention relates to peptides comprising defined amino acid sequences, compositions comprising said peptides and a pharmaceutically acceptable substance, use of said peptides as a central ..

HIGH THROUGHPUT METHOD AND SYSTEM FOR IN VIVO SCREENING

Provided is a method and system for screening chemical compounds or compositions, wherein replicating entities are introduced into the yolk of an (un)fertilized egg or embryo. The method may be extend..

A BIOLOGICAL MICROFLUIDICS CHIP AND RELATED METHODS

A biological microfluidics chip (100) comprising a substrate (102), a microfluidic inlet port (104) defining an opening in a surface of the substrate (102), and a microfluidic outlet port (106) defini..

Novel mRNA splice variant of the doublecortin-like kinase gene and its use in cancer diagnosis and therapy

Methods for treating neuroblastoma in a subject are provided. The methods include administering to the subject nucleic acid that is capable of causing a significant reduction of the amount of doubleco..

A CELL CULTIVATION RECEPTACLE AND RELATED APPARATUSES

A cell cultivation receptacle (10) comprises a recess layer (11) having formed therein a downwardly extending recess (12) defining an opening (13) on an upper side of the recess layer (11). The recess..

METHODS FOR IMMOBILIZING MICROVESICLES, MEANS AND METHODS FOR DETECTING THEM, AND USES THEREOF

The invention provides a method for immobilizing microvesicles to a coated surface using a laminar flow. Further provided are a chip mould for the preparation of microfluidic chips suitable for use in..

FUTURE CARDIAC EVENT BIOMARKERS

The present invention relates to the identification of chemokine biomarkers predictive of future acute coronary syndromes including unstable angina pectoris (UAP). The present invention also identifie..

Novel Cross-Linkers For Obtaining Structure Information On Molecule Complexes

The present invention describes a novel cross-linker, a method for preparing one or more cross-linked biomolecules, biomolecular complexes of two or more biomolecules, a method for preparing cross-lin..

SYNUCLEINOPATHIES

Present inventions demonstrates that NHE-1 inhibiting carbonylguanidine derivatives inhibit a-synuclein toxicity. Such compounds can be used in the treatment or prevention of synucleinopathies, such a..

MUTANT AOX 1 PROMOTERS

A mutant Pichia pastoris alcohol oxidase 1 (AOXl) promoter of the wild type Pichia pastoris AOXl promoter (SEQ ID No. 1) comprising at least one mutation selected from the group consisting of : a) a t..

Biomarker for osteoarthritis and/or other ageing-related diseases, and use thereof

The invention relates to the identification of a biomarker whose abundance in bodily fluids is changed in subjects with osteoarthritis and/or other ageing-related diseases. The biomarker has applicati..

METHOD FOR THE PRODUCTION OF RECOMBINANT PROTEINS BY GREEN MICROALGAE

The present invention relates to a method for the production of recombinant proteins by algal cells, which are fresh water unicellular green microalgae belonging to the order of Sphaeropleales. The pr..

BIOMARKER FOR OSTEOARTHRITIS AND/OR OTHER AGEING-RELATED DISEASES, AND USE THEREOF.

The invention relates to the identification of abiomarker whose abundance in biologicalsamplesis changed in subjects with osteoarthritis and/or other ageing-related diseases. Thebiomarker hasapplicati..

APTAMERS DIRECTED AGAINST THE MATRIX PROTEIN-1 OF TYPE A INFLUENZA VIRUSES AND USES THEREOF

The present invention relates to nucleic acids that bind specifically to the matrix protein- 1 of type A influenza viruses and uses thereof for detecting such viruses in a sample of interest. More par..

HIV-REV-MULTIMERIZATION INHIBITING NANOBODIES

The present invention relates to an anti-HIV-Rev antibody. More specifically, the invention relates to a nanobody that is able to inhibit the multimerization of the Revprotein, and by this, it inhibit..

ENHANCING THE T-CELLS STIMULATORY CAPACITY OF HUMAN ANTIGEN PRESENTING CELLS AND THEIR USE IN VACCINATION

With the current invention, we provide new methods of enhancing the T-cell stimulatory capacity of human dendritic cells (DCs) and their use in cancer vaccination. The method comprises the introductio..

PLANT GROWTH PROMOTING PROTEIN COMPLEX

The present invention relates to a plant growth promoting protein complex. More specifically, the invention relates to the use of specific proteins from the Anaphase Promoting Complex/Cyclosome for in..

INHIBITORS OF F18+ E COLI BINDING

The present invention relates to blood group A/B/H determinant on Type 1 Core glycosphingolipids chains as recognition point for the FedF protein of F18-fimbriated Enterotoxigenic and verotoxinogenic ..

INCORPORATION OF THERMO-RESISTANT AND/OR PRESSURE-RESISTANT ORGANISMS IN MATERIALS

The present application relates to methods for producing materials having viable micro-organisms incorporated therein. More particularly, the materials are produced under high temperature and/or high ..

SUBSTITUTED 7-AZABICYCLO[2.2.1]HEPTYL DERIVATIVES USEFUL FOR MAKING PHARMACEUTICAL COMPOSITIONS

This invention provides 1-substituted-7-azabicyclo[2.2.1]heptyl derivatives, intermediates and methods for producing them, which are therapeutic agents useful for the prevention and treatment of centr..

CATIONIC LIPOSOMES FOR THE DELIVERY OF HIGH MOLECULAR WEIGHT COMPOUNDS

The present invention relates to a specific type of liposomes, denominated as SECosomes, made from a cationic lipid such as 1, 2-dioleoyl-3-trimethylammonium propane (DOTAP), a surfactant such as sodi..

METHODS AND COMPOSITIONS IN THE TREATMENT OF CORONAVIRUSES

The invention relates generally to the field of virology, and relates to the identification and characterization of the targets involved in the evasion strategy of viruses and to the use thereof in me..

LIVER-SPECIFIC NUCLEIC ACID REGULATORY ELEMENTS AND METHODS AND USE THEREOF

The present invention relates to nucleic acid regulatory elements that are able to enhance liver-specific expression of genes, methods employing these regulatory elements and uses of these elements. E..

METHODS AND SYSTEMS FOR CHANNEL SELECTION

A system and method are described for estimating a property of a neural or cardial source using inverse problem solving including a forward numerical model. The system comprises a selection means for ..

METHODS FOR PRODUCING SUBSTANTIALLY HOMOGENEOUS HYBRID OR COMPLEX N-GLYCANS IN METHYLOTROPHIC YEASTS

The present invention provides methods for effectively and efficiently converting methylotrophic yeast's heterogeneous high mannose-type N-glycosylation to mammalian-type N-glycosylation by disruption..

CELLS PRODUCING GLYCOPROTEINS HAVING ALTERED GLYCOSYLATION PATTERNS AND METHODS AND USE THEREOF

The present application relates to the field of glyco-engineering, more specifically to eukaryotic cells wherein both an endoglucosaminidase and a glycoprotein are present. These cells can be used to ..

MINICHROMOSOME MAINTENANCE COMPLEX INTERACTING PROTEIN INVOLVED IN CANCER

The present invention relates to a protein that is interacting with the minichromosome maintenance complex in eukaryotes. More specifically, the invention relates to the use of a protein, interacting ..

A PROTEOLYTIC PRODUCT OF HISTONE H2A AS A MARKER FOR CANCER

The present invention relates to proteolytic products of histone H2A. In particular, the present invention discloses a peptide having the amino acid sequence VTIAQGGVLPNIQAV which can be used to deter..

NOVEL IMMUNOTHERAPY STRATEGY

The present invention relates to polyacetal-carboxylic acids, more in particular chlorite-oxidized oxyamylose (COAM) for use as a medicine, more in particular for the treatment or prevention of cancer..

ACTIVATORS OF THE AUTOPHAGIC PATHWAY

By present invention it has been clearly demonstrated that polyamine compounds of the groups consisting of putrescine, spermine, spermidine, cholesteryl spermine, spermidine trihydrochloride, spermidi..

HSC SELF-RENEWAL

The invention is related to methods for culturing stem cells, more particularly hematopoietic stem cells (HSC). The invention relates to methods for HSC expansion and the use of factors to increase th..

FUNCTIONAL LAYERS OF BIOMOLECULES AND LIVING CELLS, AND A NOVEL SYSTEM TO PRODUCE SUCH

The present invention concerns a new process for depositing a thick compact layer of biomolecules for instance such a layer with thickness in the [mu]m scale and, for depositing a thick compact layer ..

USE OF NUCLEOSIDE ANALOGS AS ANTI-KOI HERPES VIRUS MOLECULES

The present invention relates to the use of substituted or unsubstituted bis(hydroxymethyl)-cycloprop-1'-ylmethyl nucleobase derivatives as active agents for the treatment or prevention of Koi Herpes ..

INSERTION SEQUENCE DETECTION PROTOCOL

The present invention relates to a novel microarray-based methodology, referred to as 'Sliding Window Hybridization' (SWH), for reliable and convenient detection of short nucleic acid sequences in gen..

HEPATOCELLULAR CARCINOMA

Present invention concerns a kit and an in vitro method, for evaluating a biological stage of an HCC tumour in an individual, based on a sample from the individual, comprising: deriving from the sampl..

NOVEL PHOSPHATE MODIFIED NUCLEOSIDES USEFUL AS SUBSTRATES FOR POLYMERASES AND AS ANTIVIRAL ANGENTS

This invention provides phosphate-modified nucleosides represented by the structural formula: wherein W is O or S, and wherein B, R1; R3 and R2. are s defined herein. These compounds are useful as sub..

INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES

This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neur..

STEM CELL AGGREGATES AND METHODS FOR MAKING AND USING

The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differen..

NEW ENDOLYSIN OBPGPLYS

The present invention relates to a polypeptide with an amino acid sequence according to SEQ ID NO: 1 and fragments or derivatives thereof. The present invention further relates to fusion proteins comp..

ANTIMICROBIAL AGENTS

The present invention relates to endolysin variants comprising an endolysin to which a peptide stretch with membrane or LPS disrupting activity is fused. Moreover, the present invention relates to nuc..

METHOD FOR INACTIVATING AT LEAST ONE PATHOGEN IN HUMAN BLOOD PLASMA SAMPLE

The present invention relates to a method for inactivating at least one pathogen of a human blood plasma sample, including: adiabatically compressing said sample, the temperature of said plasma being,..

ROCAGLAOL DERIVATIVES AS CARDIOPROTECTANT AGENTS AND AS ANTINEOPLASTIC AGENTS

The present invention discloses new rocaglaol derivatives and the use of rocaglaol derivatives to prevent or to limit the cardiotoxicity of an antineoplastic agent, in particular to prevent or to limi..

MECHANICALLY RESPONSIVE SUPPORTED POLYELECTROLYTE MULTILAYER FILMS

The invention concerns a mechanically responsive supported polyelectrolyte multilayer film, comprising: - an elastic substrate, on which are alternately coated: - at least one exponentially growing fi..

BIOLOGICALLY ACTIVE COMPOSITIONS, METHODS FOR PRODUCING THE SAME AND BIOLOGICAL APPLICATIONS

Use of a product from plants comprising extracts, fractions and/or molecules as G-protein coupled receptor (TGR5) specific agonist, having minimum effective concentration (EC50) of greater/equal to TG..

TOCOPHEROL DERIVATIVES WITH A LONG HYDROXYLATED CHAIN, WHICH CAN BE USED AS NEUROTROPHICS

La présente invention a pour objet tout composé isolé ou synthétique, et en particulier les composés de formule (I), provoquant la différentiation de cellules précurseurs d'oligodendrocytes, ai..

MONOCLONAL ANTI-CLAUDIN 1 ANTIBODIES FOR THE INHIBITION OF HEPATITIS C VIRUS INFECTION

The present invention provides monoclonal antibodies that specifically bind to the extracellular domain of human Claudin-1 on the cell surface, thereby inhibiting HCV entry into susceptible cells and ..

THIN-LAYER PHOTOBIOREACTOR WITH HIGH VOLUME PRODUCTIVITY

The invention relates to a photobioreactor (1) for the culture of cells, comprising a runoff substrate (2) having a surface inclined at an average slope along a direction of inclination (I-I) on which..

NOVEL MELANOMA ANTIGEN PEPTIDE AND USES THEREOF

The present invention relates to novel melanoma antigen peptides and specific T lymphocytes directed to said peptides and the use thereof for treating melanoma.

Method for making biochips

A method for immobilizing biological polymers such as DNA or proteins, on a solid support, by ionocovalent bond, for making biochips, and the resulting chips obtained by the method.

CELLULAR DIFFERENTIATION PROCESS AND ITS USE FOR BLOOD VESSEL BUILD-UP

The present invention relates to the use of specific oxygen concentrations for implementing a process of differenti-ation of stem, provided that said stem cells are not humanembryonic stemcells, and s..

MUTATED HYPERTHERMOPHILIC PHOSPHOTRIESTERASES AND USES THEREOF

A subject of the present invention is mutated hyperthermophilic phosphotriesterases (PTEs) possessing a lactonase activity, and their uses as bioscavengers within the context of the decontamination of..

THERAPEUTIC PEPTIDES AND METHOD

A polypeptide comprising one or more sequences derived from CDR2 or CDR3 of a TREM-1 protein, characterised by the ability to treat, ameliorate, or lessen the symptoms of sepsis, septic shock or sepsi..

Peptide useful as an antimicrobial agent has a defined sequence of 14 amino acids

Antimicrobial peptide (I) has a defined sequence of 14 amino acids. Peptide (I) with antimicrobial activity has the amino acid sequence Lys Lys Lys Lys Pro Leu Phe Gly Leu Phe Phe Gly Leu Phe. INDEPEN..

C4D/C4B STANDARD FOR QUANTITATIVE FLOW CYTOMETRY OF HUMORAL TRANSPLANT REJECTION

The invention concerns an internal standard used to quantitative analysis of the risk of humoral (i.e. vascular) transplant rejection. The internal standard consists of a stable composition of the C4d..

USE OF CENTRIFUGAL PARTITION CHROMATOGRAPHY FOR PURIFYING GALANTHAMINE

The invention concerns the use of centrifugal partition chromatography in displacement mode for implementing a process for purifying galanthamine or its derivatives, from a starting composition, conta..

METHODS AND SYSTEMS FOR EXPANDING AC133+ CELLS AND DIRECTING DIFFERENTIATION

The invention provides, among other things, methods and systems for expanding CDl 33+ cells. The invention further provides methods and systems for increasing the blood flow to an ischemic tissue in a..

METHOD OF IDENTIFYING MICRO-ORGANISMS AND THEIR SPECIES IN BLOOD CULTURE

The invention relates to a method of identifying micro-organisms and their species in a blood culture by mass-spectrometry and to a device for implementing such a method.

4S-IOTA-CARRAGEENAN SULFATASE AND USE THEREOF TO OBTAIN ALPHA-CARRAGEENAN

The present invention relates to 4S-iota-carrageenan sulfatase and to the use thereof for partially or totally converting the iota-carrageenan into iota-/alpha-carrageenan or alpha-carrageenan. The in..

METHOD FOR DETECTING A CIRCULARIZED DNA, AND USE OF SAID METHOD FOR DETECTING MUTATIONS

The present invention relates to a method for detecting a circularized single-stranded DNA by means of the isothermal hyperbranched rolling circle amplification technique, in which the primers used co..

LEPTIN ANTAGONISTS

The invention relates to synthetic leptin antagonists in which at least two amino acid residues of the sequence LDFI/S of the hydrophobic binding site at positions 39-42 of a leptin polypeptide sequen..

NUCLEIC ACID MOLECULES AND METHODS FOR EXCHANGING EXON(S) BY TRANSSPLICING

The present invention provides methods and compositions for generating novel nucleic acid molecules through targeted spliceosome mediated simple or double trans-splicing. The compositions of the inven..

A STIMULATABLE ASYMMETRICAL POLYMERSOME

The invention relates to a polymer vesicle with an asymmetrical unilamellar membrane, said membrane being constituted by two distinct layers, a layer (A) and a layer (B), said layers comprising respec..

NON-AUXOTROPHIC SELECTION MARKER

A non-auxotrophic selection marker located in a gene cluster encoding a metabolite for an organism, such as a fungus, lacking said marker is provided. The selection marker gene can be used to detect a..

METHOD FOR DETECTING PHOSPHOPANTETHEINYL TRANSFERASE ACTIVITY

The invention provides a method for detecting 4 -phosphopantetheinyl transferase (4 PPTase) activity, the method comprising the steps of: (a) immobilising a carrier protein domain or a functional frag..

A METHOD FOR SCREENING COMPOUNDS

A method of screening compounds or molecules comprising the steps of: translating a sequence encoding the amino acid sequence comprising SEQ ID No. 29 in a translation system in the presence of a test..

Modulation of tissue fatty acid composition of a host by human gut bacteria

The current invention provides use of a CLA - producing bacterium for the in vivo conversion in the gut of polyunsaturated fatty acids to CLA. The CLA-producing bacterium is selected from one or more ..

ORALLY ADMINISTERED BACTERIA AS VEHICLES FOR SYSTEMIC DELIVERY OF AGENTS

The current invention relates to the use of a bacterial species in the preparation of a composition adapted for oral administration for the delivery of an agent to a site in the body. The site in the ..

METHOD FOR OPENING TIGHT JUNCTIONS

The present invention is directed to a method and use of RNA interference (RNAi) for the transient, reversible and controlled opening of the tight junctions of the blood brain barrier and/or the blood..

CYTOKINES AS PROGNOSTIC MARKERS OF RESPIRATORY-TRACT INFECTION FOLLOWING MAJOR SURGERY

The invention relates to the use of a certain subset of cytokine markers as prognostic variables of infection status in an individual, and especially as prognostic markers of a patients developing sev..

A METHOD OF ESTIMATING SEPSIS RISK IN AN INDIVIDUAL WITH INFECTION

A method of estimating sepsis risk in an individual with infection comprises a step of assaying a biological sample from the individual for an IL-2 or IL-7 mRNA value, and correlating the mRNA value w..

RNAI IN BUDDING YEAST

The invention provides budding yeast that have a functional RNAi pathway. The invention provides RNAi pathway polypeptides derived from budding yeast that have an endogenous RNAi pathway. In some embo..

METHOD FOR PRODUCING POLYHYDROXYALKANOATE

A method for producing polyhydroxyalkanoate (PHA), comprising (i) culturing in a culture medium comprising terephthalic acid and/or a salt thereof and/or an ester thereof one or more bacterial strains..

PSEUDOMONAS PUTIDA STYRENE MONOOXYGENASE VARIANTS

The present invention provides isolated polynucleotides derived from Pseudomonas putida, and encoding polypeptides having styrene monooxygenase activity. The polynucleotides of the present invention a..

A METHOD FOR PREDICTING ATHLETIC PERFORMANCE POTENTIAL

A method and assay for predicting athletic performance potential of a subject, such as a thoroughbred race horse, comprising the steps of assaying a biological sample from a subject for the presence o..

A METHOD OF IMMOBILISING BIOLOGICAL MOLECULES TO A SUPPORT AND PRODUCTS THEREOF

A support comprising a substrate, wherein a surface of the substrate comprises functional amino or aldehyde groups, for the covalent binding of a biomolecule. The biomolecule may be a protein such as ..

ANTI-SIALIC ACID ANTIBODY MOLECULES

A method of generating and isolating a recombinant high affinity anti-sialic acid antibody molecule comprises the steps of immunising a host with an immunogen comprising a conjugate of sialic acid and..

A MULTI-WELL PLATE FOR BIOLOGICAL ASSAYS

A multi-well plate (1) for a biological assay comprising a plate frame (4) attached to a support substrate (7) through a gasket (5) wherein the plate frame (4) defines side walls for a plurality of we..

ISOTHERMAL AMPLIFICATION METHOD FOR DETECTION OF NUCLEIC ACID MUTATION

A method is provided for detection of a nucleic acid region in a biological sample, by use of an isothermal amplification reaction, such as loop-mediated isothermal amplification (LAMP). In particular..

CRYSTAL STRUCTURE OF A PLASMA MEMBRANE PROTON PUMP

The present invention relates to a crystal structure of a plasma membrane proton pump type ATPase. The invention further describes method for identification of modulators of ATPases as well as uses of..

SUBMERGED PERFUSION BIOREACTOR

The present invention discloses a device for biological purposes such as cell culturing, enzymatic reactions or filtering of fluid, which comprises a body having a first and a second surface, and wher..

COMPOSITIONS AND METHODS FOR TREATMENT AND DIAGNOSIS OF SYNUCLEINOPATHIES

A method of treating a neurodegenerative disorder is provided, wherein compound, which inhibits or down-regulates the expression of a gene selected from the group consisting of Gadd45a, Gadd45b, Gadd4..

TFF3 HYPOMETHYLATION AS A NOVEL BIOMARKER FOR PROSTATE CANCER

The present invention relates to a TFF3 gene as a marker of prostate cancer. The present invention thus relates to methods for diagnosing prostate cancer or predicting or prognosticating the disease o..

SELECTIVE EXOSITE INHIBITION OF PAPP-A ACTIVITY AGAINST IGFBP-4.

The present invention relates in one embodiment to PAPP-A exosite(s) interactors such as antibodies which bind to a region comprising LNR3 of PAPP-A and efficiently inhibit proteolysis of IGFBP-4, but..

BIOCOMPATIBLE MATERIALS FOR MAMMALIAN STEM CELL GROWTH AND DIFFERENTIATION

A biocompatible material, wherein at least a part of a surface of the biocompatible material is characterized by a micro or nano-meter scale topographical structure comprising a plurality of features ..

MODIFIED PEPTIDES AS POTENT INHIBITORS OF THE PSD-95/NMDA RECEPTOR INTERACTION

The present invention is directed to the provision of small molecule inhibitors of the PSD-95/NMDA receptor interaction, employing an undecapeptide corresponding to the C-terminal of the NMDA as a tem..

USE OF NOVEL BIOMARKERS FOR DETECTION OF TESTICULAR CARCINOMA IN SITU AND DERIVED CANCERS IN HUMAN SAMPLES

The present invention relates to methods and kits for identification of testicular carcinoma in situ (CIS), gonadoblastoma (a CIS-like pre-cancerous lesion found in dysgenetic gonads) and CIS-derived ..

DNA-BASED METHODS FOR CLONE-SPECIFIC IDENTIFICATION OF STAPHYLOCOCCUS AUREUS

MRSA CC398 is a clone of S. aureus that has recently emerged in pigs and other domestic animals worldwide. As any other MRSA, the clone displays high levels of antibiotic resistance and poses a seriou..

BIOSYNTHETIC ENGINEERING OF GLUCOSINOLATES

The invention provides methods and materials, such as newly characterised genes, and novel processes, for converting a host from a phenotype whereby the host is unable to carry out glucosinolate (GSL)..

Porcine polymorphisms and methods for detecting them

Identification of a pig as resistant or non-resistant to enterotoxigenic E. Coli (ETEC). Particularly, there is provided methods, probes and DNA molecules involved in identifying a pig as resistant or..

A NUCLEOTIDE VACCINE

The present invention relates to a vaccine comprising a nucleic acid construct such as a DNA construct especially a nucleic acid construct comprising sequences encoding invariant chain operatively lin..

Thermostable DNA polymerase of the archaeal ampullavirus ABV and its applications

The present invention is directed to the thermostable DNA polymerase protein of the archaeal ampullavirus ABV (Acidianus Bottle-shaped virus) and the nucleic acid encoding said DNA polymerase. The inv..

FLAVIN MONOOXYGENASES AND TRANSCRIPTION FACTORS INVOLVED IN GLUCOSINOLATE BIOSYNTHESIS

The invention provides methods and materials relating generally to plant derived flavin-containing monooxygenases (FMOs) capable of catalysing oxidation of a thio- to a sulphinyl- group during glucosi..

ANALYSING BREATH SAMPLES FOR VOLATILE ORGANIC COMPOUND

The invention describes the use of a biomarker pentylfuran to detect bacterial and/or fungal pathogens. Pentylfuran is released from certain pathogens and detected in the headspace gas of an in vitro ..

NITRIC OXIDE DONORS

The invention relates to novel NO donors which are targeted to the mitochondria. The NO donor compounds of the invention allow NO to be selectively provided to the mitochondria.

DETECTION OF VOLATILE COMPOUNDS AS MARKERS FOR MYCOBACTERIA TUBERCULOSIS

The invention relates to the use of biomarkers for identifying bacterial pathogens. In particular, the invention relates to the detection and identification of certain compounds as markers for mycobac..

ANTI-CANCER COMPOSITIONS CONTAINING A SHARK MEAT EXTRACT AND A MUSHROOM EXTRACT

The invention relates to anti-cancer compositions comprising synergistically effective amounts of an extract of shark meat and an extract of a mushroom, in particular, compositions containing a shark ..

FUSION POLYPEPTIDES AND USES THEREOF

The invention relates to fusion polypeptides comprising a polynucleotide-binding domain, such as a DNA-binding domain, and a ligase domain, such as a DNA ligase domain, methods for the production of s..

Immunogenic polypeptide isolated from mycobacterium avium subspecies paratuberculosis and uses thereof

The present invention relates to an immunogenic polypeptide isolated from Mycobacterium avium subspecies paratuberculosis and variants of the polypeptide. The polypeptide and variants may be used in v..

MEMBRANE PROTEIN EXPRESSION SYSTEM AND ITS APPLICATION IN DRUG SCREENING

PROBLEM TO BE SOLVED: To provide a convenient in vitro membrane protein expression system using an inhibitor of drug efflux pump proteins and heterologous cells for testing other drug resistance-relat..

Peptoid compounds

The invention relates to new peptoid compounds of formula (I), as well as their use in the treatment of bacterial infections, such as those caused by vancomycin resistant microorganisms, and to compos..

CRYSTAL STRUCTURE OF A BACTERIAL ENZYME AND USES THEREOF

The present invention is predicated, in part, on the determination of the crystal structure of Staphylococcus aureus biotin protein ligase. The present invention provides, among other things, the crys..

DUAL FUNCTIONING IONIC LIQUIDS AND SALTS THEREOF

Disclosed herein are ionic liquid compositions comprising active pharmaceutical, biological, and nutritional compounds, and methods of use. Further disclosed are compositions of matter including liqui..

A NEURAL ANALYSIS SYSTEM

A neural analysis system, including: a neural event extractor for generating Sp/Ap curve data and field potential data for background and initial response segments obtained from a person; a correlator..

NAVIGABLE SYSTEM FOR CATHETER BASED ENDOVASCULAR NEUROSURGERY

A navigable system for catheter based endovascular neurosurgery including: a micro-motor (3) including a piezoelectric actuator (5) mounted to a free end of a guidewire or micro-catheter (2), the piez..

TESTING DEVICE FOR IDENTIFYING ANTIGENS AND ANTIBODIES IN BIOFLUIDS

A testing device for identifying an antigen or antibody within a biofluid sample including: a substrate having a hydrophilic surface thereon; the surface including a collection zone, and at least one ..

Anti-angiogenic agents and methods of their use

The present invention relates to the use of sFRP-4 and functional variants thereof as anti-angiogenic agents. It relates to methods of treatment and screening methods using sFRP-4 and functional varia..

A COLLAGEN SCAFFOLD FOR CELL GROWTH AND A METHOD FOR PRODUCING SAME

A bioscaffold and method of manufacture is described. The bioscaffold comprised greater than 80% type I collagen fibers or bundles having a knitted structure providing tensile load strength. The metho..

METHOD FOR PREDICTING ENGRAFTMENT POTENTIAL

The invention relates to methods for the identification of proliferating stem cells in products for transplantation, and uses thereof. More specifically, the invention relates to methods for predictin..

CLASSIFICATION OF BIOLOGICAL SAMPLES USING SPECTROSCOPIC ANALYSIS

A method and system is described for rapidly classifying a sample of a biological fluid, comprising obtaining a spectrum of the biological fluid in response to excitation of the sample in a specified ..

INJECTABLE BIOMATERIALS

Injectable biomaterial compositions formed from tropoelastin for tissue repair and restoration. The compositions include a coalescence-controlling agent in the form of a polysaccharide or polysacchari..

THERAPEUTIC AND DIAGNOSTIC MOLECULES

The present invention relates to methods for modulating angiogenesis, comprising administering to a subject, or cells or tissue derived therefrom: (i) one or more miRNA, or precursors or variants ther..

A NOVEL REGULATOR OF CELLULAR SENESCENCE

Provided herein are methods for regulating whether a cell undergoes apoptosis or senescence, comprising modulating the level of expression an/or activity of SENEX in the cell, wherein increasing the e..

BIOCOMPATIBLE MATERIAL AND USES THEREOF

The present invention relates to a biocompatible ceramic material comprising Sr, Mg or Ba doped Hardystonite (Ca2ZnSi2O7 ), and a method for its synthetic preparation. The present invention also relat..

ENHANCEMENT OF MICROBIAL COLONIZATION OF THE GASTROINTESTINAL TRACT

PROBLEM TO BE SOLVED: To provide a composition not only transporting probiotic microorganism to the large bowel but also containing a medium functioning to promote the growth of microorganisms when ar..

Method of screening multiply transformed cells using bicistronic expression of fluorescent proteins

A method of screening multiply transformed/transfected cells to identify those cells expressing at least two peptides or proteins of interest. The method comprising: 1. Simultaneously or sequentially ..

A METHOD OF TRANSFECTION AND COMPOSITIONS THEREFOR

The present invention relates to the targeted delivery of molecules to cells expressing toll-like receptors (TLRs). Aspects of the invention provide compounds comprising a positively charged group lin..

AN ASSAY FOR MONITORING A NEUROLOGICAL CONDITION

The present invention relates generally to biomarkers of neurological conditions including monitoring disease progression and the clinical severity of symptoms. More particularly, the present inventio..

POLYSACCHARIDE SYNTHASES (H)

The present invention relates generally to polysaccharide synthases. More particularly, the present invention relates to (1,3; 1,4)-ss- D-glucan synthases. The present invention provides, among other ..

IMMUNOMODULATING COMPOSITIONS COMPRISING INTERLEUKIN 13 INHIBITORS AND USES THEREFOR

This invention relates generally to compositions and methods for modulating immune responses. More particularly, the present invention relates to the co-expression, co-location or co-presentation on h..

UDP-GALACTOPYRANOSE MUTASE FROM HAEMONCHUS CONTORTUS, AND RNAI AGENTS THAT INHIBIT IT

The invention relates to the cloning of the Haemonchus contortus UDP-galactopyranose mutase gene, which is homologous to the C elegans glf-1. Also disclosed is the use of RNAi agents targeting this en..

INHIBITION OF DEGRADATION OF EXTRACELLULAR MATRIX

This application realtes to a method of inhibiting the degradation of an extracellular matrix associated with islet beta cells, said method comprising contacting said extracellular matrix with an effe..

Generation of cartilage using magnetizable particles

There is described a method of magnetically manipulating a cell in vivo which comprises the association of a magnetizable particle with a cell. More particularly, there is described a method of magnet..

Whitened exine shells

A whitened exine shell haying a degree of whiteness (L*) of greater than 65 measured under D 65 illumination. The shell can be used as a delivery vehicle for an active substance, or as an antioxidant...

Method of obtaining exine shells of narurally occurring spores

A method for obtaining exine shells of naturally occurring spores directly from harvested biological material, the method comprising the steps of (a) treating the material with a mixture of an acid an..

Culture of Crypthecodinium cohnii and microorganisms derived therefrom

Crypthecodinium cohnii, or microorganisms derived from Crypthecodinium cohnii, are grown in a culture medium including propionic acid. The propionic acid increases the production of one or more of dry..

MICROTRENCH AND TUMOUR PROLIFERATION ASSAY

There is provided a cell culture microtrench being defined on or in a surface of a substrate, wherein the ratio of the width of the microtrench to the maximum length of the short axis of a cell type o..

PEPTIDES DERIVED FROM THE NEURAL-RESTRICTIVE SILENCER FACTOR REST AND USE THEREOF

The invention relates to peptides derived from neural-restrictive silencer factor which modulate expression of CD59 and thus affect antibody-mediated complement cytotoxicity in tumours.

VIBRATING MICROPLATE BIOSENSING FOR CHARACTERISING PROPERTIES OF BEHAVIOUR OF BIOLOGICAL CELLS

There is described a method of characterising a property or behaviour of at least one biological cell. The method comprises the steps of: providing a microplate; submerging at least one surface of the..

ACETIC ACID AND A BUFFER

The present invention relates to a composition comprising : a) 0.01-20% wt/wt acetic acid and b) a physiologically tolerable buffer capable of maintaining acetic acid at a pH in the range of 2-7; and ..

COMPOSITIONS AND METHODS OF USE OF STANDARDIZED MIXTURES

The present invention is directed to methods and compositions for evaluating nucleic acids, methods of preparing such compositions, and applications and business methods employing such compositions an..

METHODS AND COMPOSITIONS FOR IDENTIFYING BIOMARKERS USEFUL IN CHARACTERIZING BIOLOGICAL STATES

The present invention relates to methods, compositions, and kits for identifying biomarkers useful in characterizing biological states. In particular, the invention relates to methods and compositions..

BIOMARKER

Described are gastrointestinal cancer specific biomarkers comprising the nucleic acid sequence of the Engrailed-2 (EN2) gene or the amino acid sequence of the encoded EN2 protein. Also described are u..

BIOMARKER ER2 FOR GYNAECOLOGICAL CANCER

Described are gynaecological cancer specific biomarkers comprising the nucleic acid sequence of the Engrailed-2 (EN2) gene or the amino acid sequence of the encoded EN2 protein. Also described are use..

PEPTIDIC CONJUGATES COMPRISING POLYHISTIDINE SEQUENCE AND FREE CYSTEINE AND THEIR USES IN IMAGING

Bioconjugates for use in imaging are disclosed include a linker sequence fused to a polypeptide capable of binding a target in a biological system. The linker sequence is designed so that it is capabl..

MICELLAR COMPOSITIONS FOR USE IN BIOLOGICAL APPLICATIONS

This invention relates to a composition comprising a micelle for use in biological applications, the micelle comprising: a substantially water-insoluble conjugated polymer which exhibits luminescence ..

ELECTRICALLY CONDUCTIVE DNA POLYMER HYBRID AND METHOD OF MANUFACTURE

An electrically conductive DNA polymer hybrid, in particular a DNA polymer hybrid nanowire comprising a polymer having a first functional group that is complementary to a second functional group on a ..

MARKERS OF OOCYTE VIABILITY

There is disclosed a method of determining the potential of individual oocyte to develop into a viable embryo, which method comprises establishing the concentration of any one or more of the markers i..

SCAFFOLD

The present invention provides a polymeric scaffold containing an antibacterial photoactive drug and optionally comprising seeded cells such as stem cells. The invention also includes methods of using..

AN AGENT FOR TRANSPORTING NUCLEAR SPIN ORDER AND FOR MAGNETIC RESONANCE IMAGING

An agent for magnetic resonance studies, the agent comprising hyperpolarized 15N labelled N2O in solution or liquid 15N-N2O.

TISSUE ANALYSIS

The present invention provides a method of tissue analysis, disease modelling or drug development comprising the steps of providing a tissue sample comprising cells of at least two different cell type..

A METHOD OF DETECTING A SUBJECT AT RISK OF, OR HAVING, AN INDICATION ASSOCIATED WITH CORONARY ARTERY DISEASE

There are disclosed methods and biomarkers for detecting an indication associated with, or risk of, coronary artery disease In an embodiment, a method includes obtaining a sample including bone marrow..

FLUIDICS APPARATUS AND FLUIPICS SUBSTRATE

A fluidics apparatus is disclosed for manipulation of at least one fluid sample, typically in the form of a droplet. The apparatus has a substrate surface with a sample manipulation zone for location ..

METHODS CONCERNING PPAR DELTA AND ANTAGONISTS THEREOF

Non-human animals which overexpress PPARd or which express transgenic PPARd are useful as models for inflammatory skin conditions such as psoriasis. Test substances can be screened to assess their sui..

APPARATUS AND METHOD FOR THE DETECTION OF CELLS

An apparatus and method for in-vivo detection of magnetically labelled biological molecules or cells, located in a flowing medium in a human or animal body such as the blood stream (13). The apparatus..

BIOMOLECULE BINDING LIGANDS

The invention provides biomolecule binding ligands, collections of biomolecule binding ligands, and their use in the purification of biological mixtures and in the identification of ligands having an ..

SUPRAMOLECULAR HANDCUFFS IN POLYMERIC ARCHITECTURE

This invention pertains generally to supramolecular polymers comprising a polymeric molecule linked to a first CB[8] guest molecule and an attachment compound linked to a second CB[8] guest molecule, ..

Composite biomaterial formed by cooling a fluid composition on a porous solid and removing solidified crystals of the liquid carrier

A process for the preparation of a composite biomaterial comprising providing a first solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthe..

PROTEIN AGGREGATION PREDICTION SYSTEMS

We describe methods for identifying aggregation-prone regions in structured-that is folded-proteins. Embodiments of the method use a local propensity for aggregation (Ai) at an amino acid position, th..

AGENTS FOR DETECTING AND IMAGING CELL DEATH

This invention relates to molecular imaging agents comprising an S78C mutant synaptotagmin I C2A domain. These agents may be useful in detecting or assessing cell death in vitro and in vivo, for examp..

TRX1 Antibodies

Humanised antibodies, TRX1 include modified constant regions and light and heavy chain framework of human antibody and CDR regions derived from a mouse monoclonal antibody. TRX1 binds to an epitope of..

Galvanic micro-pump e.g. for generating small micro-flows in bio-technology, uses partitioning wall with high resistance for convective flow of electrolyte fluid

A galvanic micro pump has two electrodes (1,2) and at least one working chamber containing an electro-liquid and with each working chamber joined via an ion-conductive partitioning wall to a second ch..

Material layer and electro-surgery system for electrosurgical tissue fusion...

The invention relates to a biocompatible material layer for use as an intermediate layer between tissue surfaces to be fused with a fusion of body tissue. The layer of material is such that it causes ..

CELL SEPARATION DEVICE, CELL SEPARATION SYSTEM AND CELL SEPARATION METHOD

A cell separation device which can perform a continuous processing without bonding fluorescent molecules or magnetic particles to the surface of the cell membrane, a cell separation system, and a cell..

The reduction of redox-sensitive substances by bacteria of the genus Alteromonas or Shewanella

Bio-treatment of aqueous effluents, in particular to remove colour therefrom, is carried out in a Continuous Oscillatory-flow Baffle Reactor. Redox-sensitive substances are reduced by means of bacteri..

Automated Vitrification System

Market Opportunity Cryopreservation of biological materials by vitrification has made significant inroads in displacing the more conventional slow-freeze process. However, technicians must conduct a..

Laplace Pressure Trop for Microfluidic Droplet Formation from Asynchronous Sources and Different Inlets

Tech ID: 21232 Brief Description Researchers have developed a Laplace pressure trap that can fuse droplets from different inlets and fuse droplets generated at different frequencies. The device tr..

Device for High Efficiency Cell Encapsulation using Novel On-Demand Droplet Generation and Impedance-Based Detection

Tech ID: 21236 Brief Description Researchers have developed a novel microfluidic device that is capable of encapsulating cells at a very high efficiency. The device integrates impedance measuremen..

Colloidal Self-Assembly of Droplets for High Density Microfluidic Micro-Reactor Arrays with High Throughput Functionality

Tech ID: 21274 Brief Description Researchers have developed a simple method for the rapid self-assembly of predictable high density droplet-reactor arrays for high throughput microfluidic applicat..

Microfluidic Device using Dielectrophoresis Separation of Heterogeneous Cell Populations

Tech ID: 21272 / UC Case 2011-181-0 Brief Description Researchers have developed an automated microfluidic device that traps different cell populations in different chambers based on the cells’ ..

Facile Method for Modifying Retrovirus Envelopes to Purify Retroviruses and/or to Enhance Gene Delivers

Tech ID: 21217 Brief Description Researchers have developed a novel and convenient method to molecularly tune the exterior surface of retroviruses. The glycoproteins on the surface of viruses an..

High Strength Nanotechnology-based Inorganic Binder

A technology platform that permits the creation of inorganic solids with very high compressive strength, which permits the creation of light weight, fire resistant, mineral foam composites. These s..

Chitosan Green Tea Polyphenol Complex for Wound Healing

In recent years, oxidative stress has been implicated in a variety of degenerative process and diseases, including acute and chronic inflammatory conditions such as wound healing. Green tea polypheno..

Label-Free Protein Detection

Background Conventional methods to detect the presence or quantity of specific proteins or other molecules in biological samples rely on the use of target-specific probes such as antibodies, which c..

Superior Liquid Uptake Resins for Polymer-supported Synthesis (SLURPS)

Background Solid phase synthesis, or polymer-supported synthesis, is a technique for chemical transformations in which molecules are bound to a solid, such as a polymer bead, during the reaction and..

Cucumber Mosaic Virus Inducible Viral Amplicon (CMVIVA) Expression System

Tech ID: 11438 / UC Case 2006-640-0 Abstract A Chemically Inducible Cucumber Mosaic Virus Amplicon Expression System for Production of Recombinant Proteins in Plant-Based Systems Full Descript..

Cost-Efficient, Biodegradable Microspheres with Control of Diameter, Density, Color and Surface Chemistry

BACKGROUND: Currently commercialized microspheres for flow measurement and bioscience applications are manufactured via polymerization processes that are costly or impossible to customize and require ..

A New Method to Enhance Nerve Growth

BACKGROUND: Stroke and CNS injuries together cost Americans an estimated $75 billion a year in medical and rehabilitation expenses and lost productivity. Currently, there are no effective, clinicall..

Method to Diagnose Giant Cell Arteritis

BACKGROUND: Giant cell arteritis is an inflammatory disease that primarily affects arteries in the head and neck. In the U.S. alone, it is estimated that 200 per 100,000 people over the age of 50 deve..

End-Specific Antibody to Detect Apoptosis

BACKGROUND: Programmed cell death or apoptosis is a critical event in normal cellular differentiation and development as well as in degenerative diseases, cancer and aging. Currently, the most widel..

Expression and Purification of ATM Protein using Vaccinia Virus

BACKGROUND: Ataxia telangiectasia (AT) is a genetic recessive disorder involving a large range of symptoms including telangiectasia (dilation of blood vessels) on the eyes, face, and shoulders, ataxi..

New Factor involved in Lipid Disorders

BACKGROUND: Fat cells, or adipocytes, are a specialized cell type that synthesize and store fat (triglycerides) in periods of nutritional abundance, and hydrolyze these fats when needed to meet deman..

Diagnostic Test for Mutations in the AT Gene

Technique for Expressing any RNA in Curcular Form

Antisense mRNA and ribozymes (catalytic RNA) have great potential for controlling gene expression. A major road block remains: many linear anti-sense or ribozyme RNAs are unstable when expressed in l..

Glucanase Regulation of Plant Growth and Development

Hydrolysis of the polysaccharides that compose plant cell walls is critical to cell expansion, and is therefore a key process in governing the growth and development of plants. Specifically, beta-gluc..

Commercial Auxin Substitute

A University of California researcher has identified a low-cost, non-toxic compound that can be exogenously applied to plants as foliar sprays to annual vegetable and perennial tree crops under commer..

Multiplexing Protein Binding Microarrays for Genetic Analysis

BACKGROUND: Our ability to understand and practically benefit from the control logic encoded in the human genome is currently limited by a lack of accurate information regarding promoter regulation. G..

Safe and Potent Synthetic Lung Surfactant for Treating RDS and Acute Asthma

BACKGROUND: The use of lung surfactant dispersions, based on lipid and protein components extracted from animal lung tissue, has significantly reduced mortality and morbidity from respiratory distress..

Enzyme for Antimicrobial and Vaccine Development

Scientists at the University of California have shown that a specific enzyme is an essential regulator of Salmonella virulence. This enzyme is prevalent in many organisms including most enterobacteria..

Method and Probes for the Identification of Microbial Genes specifically induced during Host Infection

BACKGROUND: Pathogenic microbes express certain virulence properties only during the infection of a host. Attempts to identify these virulence factors and to develop methods to control infections by t..

Novel Antisense Agent

University of California scientists have synthesized novel oligonucleotide analogs for use in antisense and related applications. Unlike ordinary DNA and RNA strands, the U.C. analogs incorporate modi..

indian patent published " NANOGENESEQ CHIP DESIGN''

NANOGENESEQ has designed an innovative sequencing system design consisting of two key components: a) The Hardware component b) The Software component The hardware component of NANOGENESEQ sequencin..

Inexpensive, Sensitive, Rapid and Selective Detection of GHB (Gamma-Hydroxybutyrate)

Researchers at the University of California have invented a rapid, selective, sensitive, and inexpensive enzyme-based colorimetric assay for GHB that will provide means by which: * People can prote..

Use of Vanadium Bromoperoxidase as a Signal-Generating Enzyme for Chemiluminescent Systems: Test Kits and Analytical Methods

PATENT ABSTRACT: Aqueous compositions, test kits and methods can be used to detect hydrogen peroxide or vanadium bromoperoxidase by generating a chemiluminescent signal in the presence of the analy..

Tough, Self-Healing Silicone Materials

Siloxane- and organosiloxane-based materials (collectively termed "silicones") are ubiquitous in commercially available goods and high technology applications, often in the form of oils, rubbers, resi..

Initiators for Block-Copolypeptide Synthesis

BACKGROUND: Amino acid-N-carboxyanhydride (NCA) polymerizations employing conventional initiators (e.g. hexylamine or sodium methoxide) are plagued by chain-breaking transfer and termination reactions..

Moisture-Resistant Adhesive Polypeptides

BACKGROUND: Surgical tissue adhesives provide an alternative to suturing, packing, or stapling planes of tissue together. Use of adhesives for wound closure is desirable since adhesives can be very fa..

Edible Coating for Crispy Texture in Processed Food

University of California researchers have discovered that a sweet-corn extract can be used to modify the texture of processed foods to improve their crispiness. The extract may be applied as an edible..

Recombinant Prolactin Antagonist

The hormone prolactin (PRL) exerts various effects in a wide range of physiological processes. Research suggests that PRL may promote cellular proliferation in both breast cancer and prostate cancer c..

Identification of Sortase

BACKGROUND: Hospital-borne bacterial infections present a major challenge in patient care due to the rising number of strains resistant to multiple antibiotics in recent years. Gram-positive bacteria,..

Identification of Sortase

Detection of ATM Mutations and Polymorphisms with MEGA-SSCP

BACKGROUND: Ataxia telangiectasia is an autosomal recessive disorder characterized by progressive cerebellar degeneration, immunodeficiency, growth retardation, premature aging, chromosomal instabilit..

Phosphorylation of Histone H2B as a Marker for Cell Proliferation and Differentiation in Development and Disease

BACKGROUND: Determining the cell cycle state of human cells can provide an important method for early detection of cancerous growth, especially the detection of cells at the G2/M phase of beginning ce..

Chemokine and Peptide Derivatives for Would-Healing, Fibrotic Disease Treatment, and Tumor Supression

A University of California researcher has characterized an avian chemokine that acts both directly and as an agent for various growth factors in wound-healing. The gene that encodes this protein is an..

Vectors for the Recombinant Expression of Human Immunoglobulins

Monoclonal antibodies (mAbs) are an essential tool in numerous research, therapeutic, and diagnostic applications, as mAbs can be customized to bind a desired antigen. While this is highly advantageou..

Monoclonal Antibodies and Method for Detecting Dioxins and Dibenzofurans

Polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are toxic pollutants which pose persistent threats to both the human population and to the biosphere in general. Al..

Polypeptides and Antibodies Associated with HTLV

BACKGROUND: Human T-lymphotropic viruses (HTLV) are part of a family of retroviruses called oncogenic retrovirues. HTLVs were originally identified for their ability to infect human lymphocytes, part..

Tissue-Specific Gene Inactivation of Beta-1 Integrin

BACKGROUND: Beta-1 integrin is a critical member of the large family of integrin proteins necessary for cell-extracellular matrix adhesion and bi-directional signaling across the cell membrane. Conven..

High-Speed, High-Resolution Impedance Sensor

BACKGROUND: While there has been extensive work in developing radio-frequency probes for measuring proximal impedances in air, these probes have been limited to applications using good conductors as t..

Suspended Carbon Nanotubes as Mulecular Sensors

BACKGROUND: Relatively large surfaces areas and great sensitivity to environmental conditions make carbon nanotubes (CNTs) very promising candidates for sensing elements. However, all existing CNT sen..

Platform for Chemical and Biological Sensing by Surface Enhanced Raman Spectroscopy

BACKGROUND: Surface-Enhanced Raman Spectroscopy (SERS) is an optical analysis technique that can provide molecular identification and quantification by recording a spectrum that displays characterist..

Hybrid Energy Transfer for Nucleic Acid Detection

BACKGROUND: The need for efficient assays to detect DNA sequences is enormous and constantly growing. The recent increases in the number of sequenced genomes for bacterial and viral pathogens as well ..

Electronic Detection of Molecular Targets, Including Proteins, Oligonucleotides and other small Molecules

BACKGROUND: While many assays exist for the detection of DNA, RNA, proteins and other molecular targets, most sensors require sample purity and rigorous controls available only under ideal laboratory..

One-Step Manufacture of Nanowire Biosensors

Electrochemical biosensors based on nanotubes or nanowires could be widely used in diagnostic, research, and security applications. However, the problems associated with functionalizing and placing th..

Tunable, Full-Color Electroluminescent Array

BACKGROUND: A light-emitting diode (LED) is a semiconductor device that emits visible light when an electric current passes through it. Traditionally, LEDs were made with inorganic materials. However..

Oxide-Supported Metal Nanoparticle Catalyst

BACKGROUND: Gold nanoparticles, particularly with dimensions less than 10 nm, exhibit unexpectedly high catalytic activities toward different types of reactions, a property not revealed in bulk gold...

Novel Supramacromolecular Polymer Complexes Providing Controlled Nitric Oxide Release for Healing Wounds

Technology To overcome these deficiencies, UofToronto researchers have developed a novel, stable and biocompatible system for generating a durable release of NO. This technology is based ..

Nano-Composite Polymeric Membrane System for Drug Delivery

The Background Then human body has its own homeostatic mechanisms to regulate a variety of physiologic parameters within a certain range. In instances of disease, however, these parameters..

Readily Available Unprotected Amino Aldehydes

The Technology A new class of compounds, containing two functional groups, an aldehyde and an unprotected amine has been developed. This finding has solved a significant problem in complex a..

A Novel Proangiogenic Compound

Background Angiogenesis, the formation of new blood vessels from a preexisting vascular bed, plays a critical role in tissue growth and repair. Angiogenesis is regulated by a complex collaboration ..

Newly Described Peptide with Actin Stabilizing Activity

The Background The cellular cytoskeleton functions to maintain the spatial shape and volume of mammalian cells; it is crucial for functions such as locomotion (migration), endocytosis, and phagocyt..

Thermal Dependent Injectable Polymer Matrix

Technology The technology is a novel drug delivery polymer matrix comprising an inverse thermal gelling polymer with an anionic polymer. This polymer matrix is faster gelling than each of the s..

Novel Strains of Diabetic and Nude Rats

Background Currently, the BB rat is the only available strain that spontaneously develops Type 1 Diabetes. While the high cumulative incidence (>85% in males and females) of diabetes in BB rats, an..

PoLi Implant System for Targeted and Controlled Drug Delivery

Technology The PoLi Implant Systems have several advantages over other synthetic polymer drug delivery systems. They are made of natural, fully biocompatible and biodegradable materials. The co..

Canine Embryonic Stem Cells

Background The establishment of embryonic stem (ES) cell lines has brought great promise and opportunities for regenerative medicine and pharmaceutical research. Embryonic stem cells are derived fr..

Unique Treatment for Type 2 Diabetes and Islet Cell Transplantation

Background Deposition of islet amyloid polypeptide (IAPP or amylin) fibrils is associated with over 90% of cases of type 2 diabetes, and is present regardless of the obesity of the pat..

Bioreactor Suite ()

Abstract: A major drawback of conventional reactors has been gravity-induced sedimentation of the microcarrier beads. As cell density becomes greater, the beads require more stirring, resulting in hi..

METHOD FOR INHIBITING, ARRESTING AND POSSIBLY REVERSING NON-ENZYMATIC GLYCATION

Non-enzymatic glycation and cross-linking (Maillard reaction) are well known processes which accelerate the aging of key biological molecules. For example, non-enzymatic glycation of macromolecules su..

METHOD FOR INHIBITING, ARRESTING AND POSSIBLY REVERSING NON-ENZYMATIC GLYCATION IN DIABETIC PATIENTS

Non-enzymatic glycation and cross-linking (Maillard reaction) are well known processes that accelerate the aging of intracellular proteins and extracellular structural proteins such as collagen and el..

COMPOSITIONS AND METHODS FOR REGULATING RNA TRANSLATION VIA CD154 CA-DINUCLEOTIDE REPEAT

The expression of CD154 (CD40 ligand), a member of the Tumor Necrosis Factor gene family, by activated T lymphocytes is critical in the development of humoral and cell-mediated immunity. CD154 blockad..

method for IDENTIFYING AGENTS WHICH MODULATE gtpASE ACTIVITY INVOLVED IN INSULIN-STIMULATED glut4 TRANSLOCATION

Insulin treatment of fat and muscle cells causes a rapid increase in glucose transport. The basis for this effect is an increase of glucose transporters of the GLUT4 type at the cell surface. This tra..

Regulatory T Cell MEDIATOR PROTEINS and uses thereof

Regulatory T cells (Treg) play an important role in constant and inducible control of T cells responses in vitro and in vivo. Treg cell depletion results in the induction of autoimmune pathology and e..

Nucleic acid sequences encoding luciferase for expression in filamentous fungi

Bioluminescence is the light produced in certain organisms as a result of luciferase-mediated oxidation reactions. The luciferase genes, e.g., the genes from luminous beetle and, in particular the luc..

COMPOSITIONS AND METHODS FOR INHIBITING THE SYNTHESIS OR EXPRESSION OF MMP-1 FOR TREATING, PREVENTING, OR MANAGING

Overexpression of MMP-1 is associated with several pathological conditions, including the irreversible degradation of cartilage, tendon, and bone in arthritis and the degradation of collagens I and II..

COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING CANCER VIA MODULATING UBE1L AND/OR ISG15

Individuals with acute promyelocytic leukemia (APL)(FAB M3) express oncogenic promyelocytic leukemia (PML)/retinoic acid receptora (RARa). All-trans-retinoic acid (RA) treatment causes complete remiss..

NOVEL IMMUNOTHERAPY FOR OVARIAN CANCER

Dartmouth investigators and their colleagues at the University of Kansas have discovered a novel method for rescuing cytotoxic T lymphocytes from destruction by ovarian carcinoma cells in vitro using ..

A RELIABLE, NON-RADIOACTIVE METHOD FOR MONITORING ACCUMULATION OF CHOLESTEROL INSIDE MAMMALIAN CELLS AFTER LOADING WITH LOW DENSITY LIPOPROTEIN (LDL)

Agents identified as cholesterol inhibitors are useful in preventing and treating cardiovascular and neurodegenerative diseases associated with over accumulation of cholesterol in cells. These agents ..

IDENTIFICATION AND USES OF A NOVEL TRANSCRIPTIONAL ACTIVATOR THAT USES VISIBLE LIGHT AS ITS INDUCER

Dartmouth researchers are contributing to the rapidly emerging field of regulatable gene expression. Recent research at Dartmouth has identified a protein complex that activates gene expression in res..

USE OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) FOR TREATMENT OF NEUROPATHIC PAIN

Chronic pain is a dominant health problem. It is the most common reason to seek a physician's care with nearly 40 million office visits scheduled annually. Pain costs the U.S over $100 billion each ..

Novel Method of Monitoring Angiogenesis

Angiogenesis is the formation of new capillary blood vessels as outgrowths of pre-existing vessels. This tightly regulated process plays a vital role in many physiological processes, such as embryoge..

NOVEL USE OF ASPIRIN FOR COLON CANCER PREVENTION

The American Cancer Society estimates that colorectal cancer will be diagnosed in 147,000 Americans in 2003 and will cause 57,100 deaths, making it the second-leading cancer killer. A seven-ye..

DELINEATION OF A NOVEL PATHWAY THAT REGULATES HUMAN CD154 (CD40 LIGAND) GENE EXPRESSION

The expression of CD154 (CD40 ligand) by activated T lymphocytes plays a central role in humoral and cellular immunity. The fundamental importance of this protein in mounting an immune response has m..

METHODS OF DIAGNOSING, PROGNOSTICATING AND TREATING COLLAGENASE-1 RELATED DISEASES

Degradation of the extracellular matrix is part of the pathological process associated with many diseases: e.g., joint destruction in arthritis, invasion and metastasis in cancer, bone dissolution in..

COMPOSITIONS AND METHODS FOR TREATING AND IDENTIFYING THERAPEUTICS FOR CYSTIC FIBROSIS

Cystic fibrosis (CF) is one of the most common autosomal recessive diseases in the human population. CF as a disease typically involves several different epithelial tissues. However, the principal c..

POWERFUL RESEARCH TOOL FOR SCREENING AND TESTING OF CHOLESTEROL REDUCING COMPOUNDS

Accumulation of cholesteryl esters as cytoplasmic lipid droplets within cells of human aortic tissue is a characteristic feature of early lesions of atherosclerotic plaque. These cholesteryl esters a..

NEW TREATMENT FOR LOW BACK PAIN

Low back pain is a major clinical problem second only to the common cold in its financial and symptomatic impact on human suffering. It has been estimated that 20 percent of the adult population h..

IDENTIFICATION AND USES OF A DNA DIGESTING ENZYME POTENTIALLY INVOLVED IN THE PATHWAY OF APOPTOSIS AND CELL DEATH AND USEFUL IN CONDITIONS SUCH AS CYSTIC FIBROSIS

Dartmouth researchers are contributing to the rapidly emerging field of apoptosis, which describes a pathway of cell death that is essential for normal human development and that can, when aberrant, l..

DISCOVERY OF A NEW CLASS OF ANTITUMOR AGENTS

Dartmouth researchers have synthesized a novel class of antitumor agents. These potential new drugs were designed to bind more tightly to cancer cell DNA than many conventional anticancer drugs by a ..

ALTERNATIVE SPLICING OF THE MCL-1 GENE USEFUL IN CANCER THERAPY

MCL1 is a member of the BCL2 gene family which is involved in controlling cell viability and immortalization. Because of their ability to keep cells alive, these gene products can contribute to cance..

ANTI-MICROBIAL PROTEASE INHIBITOR

Human morbidity and mortality due to bacterial infections has become a problem of great concern due to the well-publicized dramatic increase in the frequency of infections caused by bacteria that are ..

A NOVEL METHOD TO ENHANCE THE ACTIVITY OF ROUTINELY USED ANTICANCER AGENTS

Dartmouth researchers have discovered a new methodology that can enhance the activity of routinely used anticancer agents. In particular, this method appears to be selective for tumors that are defec..

NOVEL HIGH-THROUGHPUT SCREENING ASSAY FOR IDENTIFICATION OF CHOLESTEROL INHIBITORS

Dartmouth scholars developed a high-throughput screen comprised of a cell-based assay for identification of chemical inhibitors which block internalization of plasma membrane cholesterol from entering..

METHODS FOR IMMUNIZATION OR TREATMENT OF HUMANS AND ANIMALS AGAINST VIRUSES (HIV INCLUDING), INFECTIOUS AGENTS, CANCER AND OTHER GENETICALLY TREATABLE MALADIES

Apicomplexan parasites are significant pathogens of humans and animals, and cause diseases such as toxoplasmosis, malaria, cryptosporidiosis, theileriosis, and many others. For these reasons various ..

Microwave Powered Sterile Access Port (MSC-22802)

Abstract: This technology was developed to provide a less expensive, easy-to-use method for eliminating potential contamination during transfer of materials into and from bioreactors or other sample ..

MODULATION OF CELL PROLIFERATION USING HYBRID POLYPEPTIDES

MODULATION OF CELL PROLIFERATION USING HYBRID POLYPEPTIDES TECHNOLOGY REVIEWPresent therapeutic strategies for cancers such as colon cancer often involve highly toxic treatments. Further, in many case..

Mouse Null for Pigment Epithelium-derived Factor (PEDF) (21077)

Investigators at Northwestern University created an animal model useful for analyzing the role of pigment epithelium derived factor (PEDF), an endogenous inhibitor of angiogenesis, in the onset and pr..

Bioreactor (Cartridge) for in vitro Pharmacokinetic/Pharmacodynamic System

Abstract (Set) JHU scientists have developed a special bioreactor (cartridge) that permits growth of protozoan parasites for studies on the pharmacokinetic/pharmacodynamic (PKJPD) relationships of ex..

Screening Method for Smith-Lemli-Opitz Syndrome

Using this method it is possible to determine, from a small blood sample taken from a newborn, whether there are abnormalities in the sterol content of the blood. The overabundance of certain sterols ..

Precision Genetic Regulatory Elements

New versions of the LacI repressor protein with increased DNA binding affinity. The lac repressor protein (LacI) is a genetic regulatory protein widely used to control the expression of cloned genes ..

Cloning and Expression of Ginkgo biloba Levopimaradiene Synthase

Ginkgo biloba leaf extracts have been used for centuries to treat cerebrovascular and cardiovascular diseases. Recently, the American Medical Association endorsed the Chinese herb as a viable alternat..

Diterpene Production in Recombinant Yeast

Through genetic modification of Saccharomyces cerevisiae and defined culture conditions, the production of diterpenes through fermentation has been achieved. This provides an opportunity to synthesize..

TGF-Beta Conjugated Growth Scaffolds

TGF-Beta Conjugated Growth Scaffolds can be used to increase the mechanical strength of the cultured tissues by increasing extracellular matrix production. As the growth factor remains on the scaffold..

Prefabricated Tissue Engineering Bone Plug for Bone Defect Repair

Composed of materials for engineering bone tissue, this plug may be inserted into a bone defect and then used to inject and hold in place polymeric materials that enhance bone regeneration. Other appl..

Encapsulation of Radioisotopes in Carbon Nanocages for BioMedical Applications

Abstract Encapsulation of Radioisotopes in Carbon Nanocages for BioMedical Applications Technology ID: #23017 Investigator: Prof. Boris Yakobson Delivery of radioactive isotopes to specific targ..

Non-Invasive Bone and Joint Damage Detection Device

Radiography is an important diagnostic tool in medicine but unfortunately suffers from certain limitations. X-ray detection equipment is not totally portable, cannot detect certain types of injuries a..

Development of a Novel Confocal Laser Scanning Microscope for Functional Recording of Fast Neuronal Activity

Dendrites of neurons in the central nervous system are the principal sites for excitatory synaptic input. These neuronal dendrites are known to possess active computational properties also. Currently,..

Alternating Recombination Method for Assembling DNA Fragments

A process for recombination assembly of a series of cloned DNA fragments into a large ordered arrangement. Potential uses of this technology include: . Analysis of function of large interrupted codi..

Abstract Method for Assembling PCR Fragments of DNA

A process for assembling a series of DNA fragments generated by PCR into an ordered circular arrangement for replication and genetic work in cells. The method uses the 3' overhangs created by excision..

Nitric Oxide-Producing Hydrogel Materials for Preventing Arterial Blockage

Endothelial cells, normally present as a monolayer in the arterial wall, are believed to play an important role in the regulation of smooth muscle cell proliferation in vivo. Endothelial cells are ser..

Metabolically-Enhanced Microbial Strain

The key element in this new technology is that metabolic energy which would normally be diverted away from biosynthetic processes is recaptured in the form of NADH. During fermentation with this strai..

Bacteriophage Genes as the Basis for New Antibiotics

Discovery of wide-spectrum bacteriocidal proteins creates new opportunities for (a) improving phage therapy and (b) identifying important bacterial drug targets and developing new antibiotics. These b..

MUC7 20-mer Peptide: Novel and Promising Antifungal and Antibacterial Therapeutic Agent

This invention encompasses peptide derivatives of a naturally occurring protein found within the human body. These peptides have been shown to posses potent antifungal and antibacterial activity compa..

Recombinant Baculovirus that Produces Human Topoisomerase I

Introduction Eukaryotic topoisomerase I (Topo I) is capable of relaxing both negatively and positively supercoiled DNA. The enzyme catalyzes changes in the superhelical state of duplex DNA by transien..

Cell line expressing functional alpha1D-adrenergic receptors

Introduction The alpha1D-adrenergic receptor (AR) is a major regulator of cardiovascular and central nervous system function. Targeting AR is thus of major interest to the pharmaceutical industry for ..

Selective Detection of Phosphoproteins

Introduction Mass spectrometry enrichment and detection of phosphoproteins is critical to cancer research and drug development, among many applications. In MALDI-TOF mass spectrometry, metal plates de..

Continuous Production of Microcellular Fibers

Introduction In microcellular plastic foams, inert gas is dissolved in thermoplastic under high pressure. The forced evacuation of this gas during processing creates pores (or cells) within the final ..

Microcellular Foaming of Cyclic Olefin Copolymer (COC)

Introduction Cyclic olefin copolymer (COC) is a commercially available thermoplastic. It possesses exceptional clarity in its natural form, similar to that of glass, and it has high moisture resistanc..

Keratinocytes Derived from Human Embryonic Stem Cells

Summary The investigator has discovered a method for isolating and propogating keratinocytes from human embryonic stem (ES) cells. Production of an isolated keratinocyte culture proceeded step-wise fr..

A Novel Class of HIV Therapeutics: Monoclonal Antibodies that Neutralize Previously Resistant HIV Primary Isolates

Summary Background: Molecular studies of the genomic organization of HIV-1 show that it encodes a number of genes common to all retroviruses, such as the gag, pol, and env genes. The env gene of HIV-1..

Small Molecule Transcriptional Activators: Lead Agents for Gene Therapy

Summary One difficulty that has been encountered with the use of transcriptional activation systems in gene therapy is that overexpression of transcriptional activators in cells typically inhibits gen..

PTP-NP, A New Member of the Receptor Protein Tyrosine Phosphatase Family, Implicated in Development of Nervous System and Pancreatic Endocrine Cells

Summary The Flanagan Lab discovered a new member of the protein tyrosine phosphatase (PTP) family, called PTP-NP (for neural and pancreatic). The regulation of protein tyrosine phosphorylation is an i..

A New p53 Cell-Based Assay

Summary Harvard researchers developed a reliable, high-throughput screening assay to identify activators and inhibitors of p53. This cell-based luminescence assay measures the level of a reporter gene..

Modular Conditional Knockout: Precise Temporal Control of Protein Degradation in Living Cells

Summary Polyubiquitinated proteins in eukaryotes are directed to the proteasome for degradation. It is generally accepted that proteasome-mediated proteolysis depends strictly upon ubiquitination, as ..

Novel Gadolinium nanoparticles for Magnetic Resonance Lymphatic Imaging

Introduction Gadolinium (Gd3+) is chelated with diethylenentriaminepentaacetyl (DTPA) to provide contrast in magnetic resonance (MR) imaging to identify pathogenic tissues. Unfortunately, the Gd3+-DTP..

Nanocellular Foaming of Ultra High Molecular Weight Polyethylene using Ultrasound

Introduction Ultra high molecular weight polyethylene (UHMWPE) is a thermoplastic consisting of molecules of incredibly long chains with molecular weights of several million. It has the highest impact..

Production of Palladium Nanostructures with Shape Selection by Adding Bromide

Introduction Single-crystal, one-dimensional nanostructures of palladium are attractive as interconnects for fabricating nanoscale electronic devices. Polycrystalline, mesoscopic wires made of palladi..

Copper Chloride-mediated Synthesis of Silver Nanowires

Introduction Owing to the high electrical and thermal conductivity of bulk silver, the synthesis of Ag nanowires has been and continues to be an area of active research. The properties and application..

Gold Vision

Introduction A neuron or group of neurons that senses or receives light within the eye is known as a photoreceptor. Damaged or diseased photoreceptors lead to impaired vision or blindness. Local stimu..

A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid Sample

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, especially for biosensors and environmental monitoring. One recent area of interest is p..

Platelet Clotting Force Array

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, such as point-of-care diagnostic devices. These microscale diagnostic platforms will ena..

Programmable Generation and Transport of Droplets on Microscale Surface Texture Ratchets

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications. Currently, many laboratory processes can be combined on a single chip commonly only mill..

Cell and Microparticle Separator Employing Patterned Grooves

Introduction Microscale enrichment and separation are important for various research, biomedical, and industrial uses. Conventional means for these processes typically require specific labels— eith..

Signal Amplification Method for SPR-based Chemical Detection

Introduction Surface plasma resonance (SPR) is a general spectroscopic method for sensing refractive index changes near the surface of a metal film. Its sensitivity to these changes provides a versati..

3-D Tissue Culture Chamber

Introduction Many of the seminal findings in cell and molecular biology have come from cultures of cells grown in two dimensions but the limitations of biology in just 2D are becoming clear. Cells in ..

Active Biomimetic Cilia Using Nanowires

Introduction Critical challenges in emerging bio-fluidic devices lie in bio-compatible transport of small sample volumes and bio-reaction enhancement without damaging biomolecules. In nature, biologic..

Purified Compositions of Stem Cell Derived Differentiating Cells

Introduction Stem cells have a capacity for both self-renewal and the generation of differentiated cell types. Embryonic Stem (ES) cells are derived from cultures of inner cell mass (ICM) cells, and h..

Chitosan/alginate hybrid scaffolds

Introduction For the past decade, a large number of natural and synthetic porous polymeric materials have been extensively studied for use as scaffolds for bone tissue engineering. Although these effo..

HLA Homozygous Cells

Introduction Although stem cells have great potential in regenerative medicine, they can only be used effectively in recipients that have the same histocompatibility type or the cells will be rejected..

Microfabricated Thermocouples for Microfluidics and Microreactors

Introduction Continued strong growth is projected within the biochip products and services marketplace worldwide. As the number and complexity of reactions and separations that are carried out using b..

PROFILED REGULATORY SITES USEFUL FOR GENE CONTROL

Introduction The invention provides methods for quantitative profiling of chromatin sensitivity to a DNA modifying agent. The invention also relates to methods for identifying regulatory sites in a ge..

METHODS AND COMPOSITIONS FOR DIAGNOSING HEPATOCELLULAR CARCINOMA

Introduction Currently, it is difficult to diagnose HCC. Methods employed generally rely on imaging techniques such as MRI, CT, and ultrasound and are of little use in detecting the disease in its ear..

CNS Tissue-selective Transgenic Animal Mouse Model

Introduction A central nervous system (CNS) specific knockout system has been unavailable thus far due to technical limitations. Recent advances have provided exciting data based on the use a liver-sp..

Scn1A knockout mouse-a genetic animal model for human epilepsy

Introduction Epilepsy is one of the most common neurological disorders. Its pathophysiology is poorly understood and the available pharmacotherapies are effective only in a fraction of patients with f..

BCRP expressing cell lines

Introduction The breast cancer resistance protein (BCRP) is an ATP-binding cassette efflux transporter originally identified by its ability to confer multidrug resistance in cancer cells. BCRP mediate..

Dact1 (Dpr1/Frodo1) Conditional Knockout Mice

Introduction Wnts are secreted signaling proteins important in development and disease in multicellular animals. These signaling proteins help regulate cell fate specification, cell morphology, cell p..

M1 Muscarinic Acetylcholine receptor Knockout Mice

Introduction Muscarinic acetylcholine receptors are members of the G protein-coupled receptor superfamily expressed in neurons, cardiomyocytes, smooth muscle, and a variety of epithelia. The M1 recept..

A Mouse Model for Osteoporosis

Introduction Osteoporosis, an age-related disease in which loss of bone mass causes skeletal deformities and fractures, affects nearly 20 million people in the US, mostly women. A major complication i..

Type III Adenylyl Cyclase Gene Knockout Mice

Introduction The olfactory sensory system has the remarkable capacity to detect and discriminate among a wide array of odorants and translate them into cognitive representations. Cyclic nucleotide–g..

Zinc Transporter-3 Knockout Mouse

Introduction The presence of histochemically reactive zinc within synaptic vesicles defines a subset of neurons that have been termed zinc-enriched (ZEN) neurons. Because ZEN neurons are prevalent thr..

PDL2-Ig Fusion Protein

Introduction T cell activation and tolerance are critically regulated by costimulatory molecules, especially those in the B7 and CD28 superfamilies. PD-1, a novel member of the CD28 family, is express..

B7-H-Ig Fusion Protein

Introduction T cell activation and differentiation require not only T cell receptor recognition of the antigen–MHC complex but also costimulation through the interaction of accessory molecules on AP..

Type I Adenylyl Cyclase Knockout Mouse

Introduction The type I adenylyl cyclase (I-AC) is neurospecific and expressed in areas of the brain that show long-term potentiation. This enzyme is thought to play an important role in the developme..

A Yeast Ligand Sensor

Introduction The yeast ligand sensor is a novel approach for the detection and quantification of ligandbinding, an issue of great interest in drug discovery and other areas. The approach is a protein-..

NPY-Deficient mice

Introduction NEUROPEPTIDE Y (NPY), a 36-amino-acid transmitter distributed throughout the nervous system, is thought to function as a central stimulator of feeding behaviour. NPY has also been implica..

SirT1 Conditional Knockout Mice

Introduction SirT1 is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase capable of modifying the activity of many transcription factors that have been implicated in the physiology and pa..

Thrombospondin 2-null mice

Introduction Thrombospondin 2 (TSP2), a matricellular protein with a primary role in modulating cell matrix interactions, has been implicated in tissue repair and foreign body responses. Technology de..

SV2B Knockout Mouse

Introduction Synaptic vesicle protein 2 (SV2) is a membrane glycoprotein found only in the secretory vesicles of neural and endocrine cells. It appears to be unique to vertebrates, suggesting that it ..

Cyclic nucleotide phosphodiesterase 7B (PDE7B)

Introduction Cyclic nucleotide phosphodiesterases (PDEs) are enzymes hydrolyzing the second messengers adenosine and guanosine 3',5'-cyclic monophosphates (cAMP and cGMP). The human genome encodes 21 ..

SV2A/B Double Knockout Mouse

Fluorescent Microglial Cell Lines

Introduction Microglial cells are the resident immune cells of the central nervous system. Upon brain damage, these cells are rapidly activated and transform from a resting state into activated microg..

A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid Sample

Ultrasound Target Vessel Occlusion using Microbubbles

Introduction Ultrasonography is a noninvasive medical imaging technique, which utilizes ultrasonic waves in order to visualize soft tissue within the body. Advances in this technology have led to a th..

Pre-Surgical Cauterization during Minimally Invasive Endoscopic Procedures Using Ultrasound

Introduction Surgery is an essential tool in the treatment of many pathologies. Hundreds of thousands of surgical procedures are performed each year that result in the full or partial removal of organ..

Platelet Clotting Force Array

Dynamic Characterization of Particles Using Flow Cytometry

Introduction Flow cytometry is an increasingly useful analytical technique that utilizes the scattering of laser light to interrogate a variety of microparticles, including microorganisms, cells, and ..

Tissue-Engineered Urinary Bladder Using Autologous Cells

Introduction There is a variety of reasons that a person’s bladder may fail or require removal, including bladder acontractility, cancer, and cystitis. Unfortunately, conventional artificial bladder..

Advanced Biomimetic Surfaces for Surface-Enhanced Raman Spectroscopy (SERS)

Introduction Raman spectroscopy characterizes molecules by their Raman scattering. As incoming light scatters off a molecule, most does so elastically, neither gaining nor losing energy, and this is k..

Respiratory Detection System (RDS)

Introduction Respiration rates are an important indicator of cellular and metabolic states in cells ranging from mammalian to bacterial, from individuals to large populations. Unfortunately, conventio..

Technique for Detecting Loose Arthroplasty Components

Introduction Due to traumatic injury, severe arthritis, and similar conditions, total joint replacement surgery (or arthroplasty) is becoming increasingly common. Despite the field’s maturity, howev..

Guided cell patterning on gold-silicon dioxide substrates by surface molecular engineering

Introduction Cellular patterning on silicon substrates is the basis for development of integrated cell-based biosensing devices, for which long term cell selectivity and biostability remain a major ch..

Ultrasonic Probe for Determination of Kidney Stone Size

Introduction Kidney stones are a common problem for men and women worldwide that can cause great pain and lead to complications, such as infection. Conventional treatments such as extracorporeal shock..

Controllable Transverse Rotation Adapter

Introduction The process of fitting prosthetic limbs to amputees can be a long process filled with trial and error, and it is exacerbated in lower limb amputees due to painful shear stress caused by t..

New biocompatible and biodegradable polymers

Introduction Porous biodegradable scaffolds are ideal materials on which, new tissue may be grown. These new tissues are used as graft material to replace damaged tissue removed during surgery. These ..

Fluid flow assisted dielectrophoretic alignment and sorting of dielectrophoretic alignment and sorting of

Introduction The accurate and precise sorting and deposition of nano/bio materials within a nano- or micro-environment is critical for the functionality of devices such as biochips. Fluid flow in a mi..

Clutter Rejection Filters for Doppler Optical Coherence Tomography

Introduction Doppler optical coherence tomography (DOCT) is a recently developed technology that can image blood flow with high special and temporal resolution. Technology description Researchers at t..

Flexible Fiber-Optic Scanning Multiphoton or Harmonic Miniature Imaging Probe

Introduction Endoscopes are increasingly involved in performing common surgical procedures and in diagnosing cancer and other medical conditions. New technologies can demonstrate significant cost savi..

Gold Vision

Tissue-Engineered Vascular Graft

Introduction Vascular disease affects approximately 10 million Americans and is a leading factor in heart disease, stroke and diabetes. Tissue engineering offers a way to address failing organ systems..

Dynamic Change of Focus for True 3-D, Scanned Retinal Displays

Introduction Generating true 3-D computer displays will enable the creation of more realistic and informative images, allowing improved functionality when relying on visual display data. Technology de..

Design of Surface Plasmon Biosensor Based on Self-Referencing and Digital Window System

Introduction Surface Plasmon resonance (SPR) has attracted strong attention as a biosensor in the past two decades because it can provide label-free, real-time detection with high sensitivity. Technol..

Biomaterial with Engineered Vascularization

Introduction Porous biomaterials allow the penetration of nascent networks of blood vessels. The advantage of these materials is that specific biological “training molecules” can be inserted in th..

Intracellular Delivery Vector

Introduction Some drugs require cellular uptake to be effective and methods to increase cellular uptake are desired to improve on the efficacy and reduce the side-effects of certain drugs. One way to ..

Thin-film Bioreactor

Introduction The large scale production of biological materials requires the use of bioreactors. Bioreactors can also be used in biologically mediated chemical conversions and waste management. Tradit..

Protein Microarray Fabrication with Novel Functionalization

Introduction Protein microarrays are enjoying increasing use in both research and diagnostic applications. One of the key challenges in protein microarray manufacture is the fixation of the protein or..

Targeted Gene Modification by Parvoviral Vectors

Introduction Though the development of integrating vectors based on eukaryotic viruses has made possible the efficient introduction of genes into mammalian chromosomes, there are many situations where..

A method for quantitative, proteome-wide analysis of protein phosphorylation

Introduction Protein phosphorylation is one of the most important regulatory events in cells. The state of activity of numerous enzymes and processes and the association of specific proteins into func..

Carbon Nanotubes by Electrospinning with a Polyelectrolyte and Vapor Deposition Polymerization

Introduction Ever since the discovery of carbon nanotubes they attracted a great deal of attention due to the myriad of possible applications, such as in fuel cells, lithium-ion batteries, and superca..

Carbon Nanotubes by Electrospinning with a Polyelectrolyte and Vapor Deposition Polymerization

Solution Processable n-Type polymers

Introduction Conjugated polymers and organic semiconductors promise great advances in electronics because of the benefits they offer over silicon, including being cheaper with less demanding manufactu..

Microporous Micromolding

Induction Ionization Interface for Mass Spectrometry

Mass spectrometry relates to the determination of the molecular weights of individual molecules by their conversion into ions in a vacuum and then subjecting them to an electric or magnetic field or b..

3-D Tissue Culture Chamber

EOS Vectors Select for Pluripotency During iPS Cell Reprogramming (RDLP# 605)

This invention relates to the creation of a novel stem cell expression cassette called EOS that restricts reporter expression to embryonic or induced pluripotent stem cells.

A Novel Catalyst Technology for the Polymerization of ?-Olefins

The Invention A novel catalyst technology for the polymerization of alpha -olefins was developed including several families of pre-catalysts based on early transition metal complexes of amine-phenola..

Increased Fungal Biomass for Bio Ethanol Production

The Invention Dr. Amir Sharon and his team from Tel Aviv University have developed a transformation-based approach through which fungi can be modified to be less sensitive to external conditions and ..

A Potential Target For Discovery and Development of Novel Antiviral Agents Against Porcine Endogenous Retrovirus

The Invention Researchers in Tel Aviv University have cloned and characterized Reverse Transcriptase (RT) of PERV-B - a variant that infects human cells and, hence, might infect human recipients of..

Self Assembled Peptide Hydrogel

The Invention A breakthrough Self Assembled Peptide Hydrogel (SAPH) has been developed by Professor Ehud Gazit and his team at Tel Aviv University. SAPH is a safe, self assembled, biocompatible, re..

Self Assembling Peptide Nanotubes

The Invention Aromatic dipeptides have been demonstrated to self-assemble into discrete nanotubes that are, upon design, either sensitive or resistant to enzymatic degradation. Such nanotubes are hom..

Edible Anti-Adhesion Material for the Treatment of Oral Bacterial

The Invention A high-molecular-weight, non dialyzable material (NDM) isolated from Cranberry juice, specifically inhibits adhesion and dissociates co-aggregates of oral bacteria. NDM act preferably o..

Edible Anti-Adhesion Material Derived From Cranberry for the Treatment of Helicobacter Pylori Infection

The Invention An edible, high-molecular-weight, non dialyzable material (NDM) isolated from Cranberry juice inhibits specific adhesion of H. Pylori to immobilized human mucus and to cultured gastric ..

Over-Expression of Membrane Proteins in Bacterial System

The Invention The invention provides for an increase in the expression of heterogeneous membrane proteins as well as crystallization ability. This is achieved by addition of hydrophilic alpha-helical..

Targeted filamentous bacteriophages as therapeutic agents

The Invention Targeted drug-carrying filamentous bacteriophages have been developed as a novel therapeutic approach for the treatment of infectious diseases and cancer. The phages are genetically-mod..

Novel baby bottle nipple that mimics breast feeding

The Invention A new nipple for baby bottles has been developed that mimics breast feeding. The structure of the new nipple is based on the functional architecture of the breast nipple anatomy, thus e..

Novel oral formulation of Insulin

The Invention Gagomers are novel particles (neither liposomes nor microspheres/nanospheres) composed of hyaluronan shell which is crossed linked to phospholipids and can be generated either as micr..

Collagen fibers from a soft coral

A novel source of collagen manifested as fibers derived from certain species of soft corals has been isolated. The New Collagen fibers are strong and flexible compared to commercial collagen. The fi..

NOVEL ANTIMICROBIAL PEPTIDES

BACKGROUND Ai2 Limited is a University of Manchester spinout company that aims to become a significant player in the global anti-infectives market. The company’s focus is on developing novel anti-mi..

CORTICOSTEROIDS WITH REDUCED SIDE EFFECTS

BACKGROUND Glucocorticoids (GCs) have been used therapeutically for many years to treat a range of inflammatory conditions as immunosuppressants and in the treatment of certain cancers. These compound..

OPTICIN A TREATMENT FOR CANCER AND ANGIOGENESIS

BACKGROUND Opticin is a protein present in the eye (in the vitreous humour) and was discovered at University of Manchester by Dr Paul Bishop. Uniquely Opticin has been found to exhibit both cytotoxic ..

A FUNCTIONAL FOOD WITH INDICATIONS FOR PEPTIC ULCERS

BACKGROUND 1 in 10 people are affected by peptic ulcers over the course of their lifetime. Incidence of the condition is set to increase as the population ages. Current treatment relies on combination..

NOVEL TISSUE MARKER FOR STRATIFYING

BACKGROUND Research at the University of Manchester has identified a new tissue marker with potential use in the stratification of breast cancer patient groups and improved targeting of treatment for ..

SPINAL DISC NUCLEUS REPLACEMENT

BACKGROUND In the last 10 years commercial interest in treatment of spinal degeneration in relation to back pain has increased with a large number of devices competing in a market estimated to be wort..

PRODUCTION OF NOVEL HUMAN COLLAGENS

BACKGROUND A powerful new platform technology for the production of human collagens is being developed in the Kadler Centre for Cell-Matrix Research within the Department of Life Sciences at the Unive..

eLUNSERS: A SOFTWARE TOOL FOR MONITORING THE SIDE-EFFECTS OF NEUROLEPTIC DRUGS

BACKGROUND Neuroleptics are the drugs of choice in the treatment of schizophrenia, bipolar mania and related disorders but suffer from troublesome side-effects such as drug induced parkinsonism, restl..

Collaboration/Licence Opportunity Size and Permeability Selective Encapsulation and Delivery of

BACKGROUND Although there is considerable research being carried out in the area of hollow sub-micron constructs for the purposes of encapsulation of useful therapeutic entities, most of the processes..

NOVEL ANTI-HELMINTHIC

BACKGROUND Gastrointestinal nematode infections are amongst the commonest infections of man and animals worldwide. Collectively 1 in 3 people on the planet are infected by at least one species and app..

EXCIPLEX ™ A HIGHLY SENSITIVE NUCLEIC ACID FLUORESCENT DETECTION SYSTEM

BACKGROUND Conventional fluorescent dyes used in nucleic acid detection methods suffer from a number of limitations. High backgrounds result in false positives and a reduction in sensitivity. The smal..

ENZYME TARGETTED THERAPEUTICS

BACKGROUND Enzymes, especially proteases play essential roles in disease specific processes and are valuable targets for therapeutic intervention. A number of methods of targeting enzymes have been us..

Kenaf plants with elevated fiber content

The Invention Transgenic Kenaf plants (Hibiscus cannabinus L.) have been developed by modifying the endogenous concentration of gibberellins using anti-sense technologies. These novel Kenaf plants h..

ZNF206: A Novel Regulator of Embryonic Stem Cell Self-Renewal and Pluripotency

Life Extension Through Neurofibromin Mitochondrial Regulation and Antioxidant Therapy for Neurofibromatosis-1 in Drosophila...

Background: Anti-oxidant and anti-aging compounds have been screen using other animal models. However, there was no clear understanding of the molecular basis for how the screening worked and the sys..

Mitochondrial DNA Variants Associated with Metabolic Syndrome

Background: Over the past 25 years, the Wallace's laboratory discovered that the variation in the maternally-inherited human mtDNA forms a single mtDNA tree in which the branches of the tree are regi..

Energy-Saving Technological Method for Long-Term Storage of Bio-Degradable Tissue

Background: Currently the critical storage of bio-degradable tissue for long periods of time is done at -70" C. This temperature does provide nearly unlimited storage time. Storage at -70' C is subst..

Photo-electric Device and Method for High Throughput Activation, Guidance and Poration of Targeted Cells with High Spatial Resolution

Background: In biomedical research, controlled modulation of physiological functions of various excitable cells such as skeletal, cardiac and neuronal cells is important. The information derived from..

Mouse Model of Cardiac and Muscle Disease and Cancer Caused by a Mitochondrial DNA Point Mutation

Background: It is becoming increasingly clear that mitochondrial DNA (mtDNA) base substitution mutations are a common cause of age-related degenerative diseases as well as cancer. However, no mouse m..

Integrated Biomedical Multimodality Imaging Probe - Optical Coherence Tomography/Ultrasound/Photoacoustics Imaging System

Background: In clinical applications for the examination of cardiovascular, cerebrovascular, leg and other vessels, ultrasound imaging (USI) and optical coherence tomography (OCT) are two of the most..

Method and System of Elasto-Optical Tomography for Breast Cancer Imaging

Background: Currently, X-ray mammography is the widely accepted method for the detection of changes in the breast that may be cancer. However, this screening technique lacks specificity to determine ..

Accurate Classification of MLH1/MSH2 Missense Mutations with MAPP-MMR

Background: During genetic testing of the human MLHl and MSH2 genes, missense variants are sometimes encountered. It is difficult to tell if these variants are benign or deleterious. Technology: T..

APE/REF-1 as a Drug Target for Acne and Development of Potential APE/REF-1 Inhibitors for Prevention and Therapy of Acne Vulgarsis

Background: Acne vulgarisis the most common skin disorder, and while it usually appears in adolescence, adults can get it too. The pathogenesis of acne is complex and multifactorial. According to the..

A Robust Reporter Ssystem to Identify Bone Morphogentic (BMP) Activity

Background: Bone Morphogentic Proteins (BMP)s are involved in various developmental processes, but are most famous for the activity to stimulate bone formation. Technology: Through phylogenetic fo..

Fiber Optic Probe and Method for Optical Trapping, Ablation, Excitation and Detection of Microscopic Objects

Background: Manipulation of microscopic objects by laser methods has been used since the 1970s. Both laser tweezers (used to hold microscopic objects in place) and optical scissors (used to conduct d..

Method and Apparatus for Performing Qualitative and Quantitative Analysis of Wounds Using Spatially Structured Illumination

Background: Use of instruments to assess etiology and status of chronic wounds is still in an embryonic state. Clinicians rely primarily on clinical features such as wound size, location, depth, and ..

Method to Develop Mutant Protein Library

Background: Current technologies used to develop novel protein and antibody libraries have been met with limited success. Specified and controlled distribution of mutations relative to the parent pro..

Novel Antenna Angiography Catheter

Background: Cardiac catheterization is typically performed with stiff-tipped catheters. In order to engage a blood vessel orifice, the stiff tip must be positioned at a precise location, and in the c..

Fast Lysis Cell Traps

Background: Chemical cytometry involves the use of high-sensitivity analytical tools, such as mass spectrometry, electrochemistry and capillary or microfluidic separation methods to characterize sing..

A Model of Heterogeneous Ventilation and Nitric Oxide Production in the Lungs

Background: Asthma is a pulmonary disorder characterized by chronic airway inflammation and airflow obstruction that is widespread, but variable in space and time. Although airflow obstruction is rou..

Novel Method Using Laser in Assays to Induce Mechanotransduction

Background: Mechanotransduction, the process by which cells convert mechanical stresses to a biochemical signal, influences many cell functions including cell motility and proliferation and also modu..

Ergonomic Tracheal Suction System

Background: Tracheal suction catheters used today by respiratory therapists have a number of drawbacks. First, the therapist operating the tracheal suction catheter is directly exposed to the patient..

Nanosecond Laser Cell Lysis in Microfluidic Devices

Background: To date, cell lysis in microfluidic devices for analytical purposes has been achieved using chemical, electrical, and optical means. Chemical cell lysis occurs on time scales of several t..

Methods of Manufacturing Microdevices in Laminates, Lead Frames, Packages, and Printed Circuit Boards

Background: Microelectrical-mechanical systems (MEMS) are miniature mechanical devices intended to perform non-electronic functions such as sensing or actuation. These devices are typically built fro..

Rescanning Laser Scanning Confocal Microscope

Background: The laser scanning confocal microscope (LSCM) is widely used as a confocal microscopy technique for imaging fluorescent objects in a manner that removes out of focus fluorescent light and..

Optimizing Sound to Suppress Tinnitus

Background: Tinnitus is the perception of sound in the absence of corresponding external sounds. Although known for its high-pitched ringing, tinnitus is an internal noise that varies in pitch and fr..

Construction of Single Molecule Electronic Devices, with Applications to Biosensing

Background: "Molecular Electronics" (ME) generally refers to a class of novel electronic devices in which the electronic response and function are entirely controlled by single molecules. In principl..

Prokineticin 2 and Prokineticin Receptor 2 as a Target to Treat Epilepsy and Seizures

Background: PK2 belongs to a family of secreted peptides that regulate diverse biological functions including serving as a regulatory molecule for circadian rhythms. The signaling of PK2 is mediated ..

Micromachined Passive Programmable Drug Delivery Systems

Background: The ability to deliver drugs locally to the site of need and over a prolonged period of time is important as a therapeutic method for many ailments and diseases. Many drugs are more effec..

Method and Apparatus for Performing Qualitative and Quantitative Analysis of Produce (Fruit, Vegetables) Using Spatially Structured Illumination

Background: The use of wide-field, broadband, spatially illuminated imaging of turbid media has the potential for simultaneous surface and sub-surface mapping of media structure, function and composi..

High Sensitivity Optical Coherence Tomography

Background: Optical coherence tomography (OCT) is a non-invasive sub-surface optical imaging modality with high axial resolution and high signal to noise ratio compared to other imaging modalities su..

A New Mouse Model of Sjogren's Syndrome

Background: Sjogren's Syndrome is a grave autoimmune disease in which destruction of the exocrine glands leads to severe dryness of the eyes and mouth, with additional systemic complications. The pat..

THE ARHGAP18 GENE AND SCHIZOPHRENIA

Background: Correlation of brain images and genotypes for diagnostics of neuropsychiatric disorders and drug discovery Technology: The invention includes general methods for identifying markers th..

Beta-Amyloid and Neurofibriallary Tangle Imaging Agents

Background: Positron emission tomography (PET) is a non-invasive test that helps doctors diagnose abnormalities, determine the extent of disease, prescribe treatment, and track progress. The patient ..

Dynamic Skin Cooling with Non-Toxic Cryogen with Minimal Global Warming Potential

Background: An important issue in laser treatment of cutaneous lesions is to protect the epidermis from thermal damage. This heating, which is primarily caused by light absorption in the melanosomes,..

Restoring Cough Using Microstimulators

Background: Respiratory complications are the most common cause of morbidity and mortality following spinal cord injury. Patients with such injuries often suffer a disruption in the neuromuscular cen..

Integrated Direct Electron Imaging Sensors

Background: Conventional charged particle imaging sensors use film and charged couple device (CCD). CCD has poor radiation tolerance and records images indirectly while the film is an analog recorder..

Gene Encoding CRAC Channel

Background: CRAC stands for Ca2+-Release Activated Ca2+. When Ca2+ from the endoplasmic reticulum (a major store of Ca2+) is depleted, a CRAC channel, is activated to slowly replenish the endoplasmic..

CAP/SORBS1 Gene and Diabetes

Background: Diabetes Mellitus (DM) is one of the leading causes of death in the United States (Bassett). The molecular defects underlying the development of most human Type 2 DM are not yet clear. Bu..

Flexible Endoscopic Tube

Background: In performing, through an anatomical channel inside the body, a diagnostic or surgical procedure, the surgeon or operator may need to rotate with precision the distal end inside the body,..

Intragastric Balloon for Treatment of Obesity

Background: The BioEnterics Intragastric Balloon System™ is a non-surgical, non-pharmaceutical alternative for the treatment of obesity. The balloon system is designed to provide loss therapy to re..

Microfluidic Device for Forming Monodisperse Lipoplexes

Background: The determinant factor for the successful applications of delivering drugs is to develop a non-viral and efficient carrier. Cationic lipid based liposomal carriers are the most attractive..

Technique to Characterize NIitric Oxide Exchange in the Lungs

Background: It has been reported that the concentration of Nitric oxide (NO) in the exhaled breath was substantially elevated in patients with asthma who were not treated with corticosteroids, sugges..

Methodology of Elasto-Mammography

Background: It has been well recognized that the tissue stiffness plays an important role for diagnosis of breast cancers, as tumors are stiffer than the surrounding breast tissues, and malignant tum..

Methodology of Elasto-Mammography

A Novel 7 Base Deletion in the Gene on Chromosome 21 for Diagnostic of Keratoconus

Background: Keratoconus is a noninflammatory progressive corneal thinning disorder leading to mixed myopic and irregular astigmatism and is implicated as a major cause of cornea transplants in the We..

Wafer Scale Glass Blowing

Background: Large scale confinement chambers have been created in the past using traditional glass-blowing techniques. However, conventional glass-blowing can only be used to create large components ..

An Integrated Microfluidic Platform with Lateral Dielectrophoresis (DEP) Based Cell/Particle Separation

Background: Most of the current techniques used for Dielectrophoresis separation use planar electrodes which sit at the bottom of the channel. With this design the electric field decreases dramatical..

Protein Nanocapsule for Drug Delivery

Technology: University of California researchers are investigating a protein scaffold system for molecular transport, namely, the E2 protein of Bacillus stearothermophilus in the pyruvate dehydrogena..

Hybrid Binding Proteins Against Pathological Protein Aggregates in the Central

Background: The pathological protein aggregates such as beta-amyloids, alpha-synuclein and prion protein deposits in the CNS can be removed by vaccination, i.e., immunization using specific antibodie..

Wafer-Level Micro-Glass Blowing

Generation of Stable Concentration Gradients in 2D and 3D Environments Using a Microfluidic Ladder Chamber

Background: In the chemical, biomedical, and pharmaceutical industries, it has become increasingly desirable to perform large numbers of chemical operations in a highly parallel fashion. For example,..

Development of Diagnostics and Therapeutics for Cornelia de Lange Syndrome

Background: Cornelia de Lange Syndrome (CdLS) is a moderately common multisystem birth defects disorder that poses severe medical and social challenges for affected children and their families. Diagn..

Methods and Reagents for Screening New Drugs and Treating Ion Pump Associated Disorders

Background: Sodium/potassium ATPases (Na+/K+-ATPases), a family of multi-subunit ion pumps, are the most important active transporters in animal cells. They are required for maintaining the electroch..

Fabrication of Renewable RNA Microarrays and Methods

Background: Numerous methods and devices are available to detect and/or quantify target DNA in a test sample. In almost all of these methods, detection and/or quantification are performed utilizing a..

A Microfluidic Device for Enabling the Controlled Growth of Cells and Methods Relating to Same

Background: In many neurodegenerative diseases and in spinal cord injury, axons and synapses are damaged; a cell culture model is useful for investigation into these areas of research. In typical cel..

Biomarker-Guided Prediction of Patient Adherence to Medications

Background: Adherence is one of the pivotal determinants of treatment outcomes for many medical disorders. It is estimated that 50% or more of patients with chronic conditions are noncompliant with m..

LEF-1 Internal Ribosome Entry Site

Background: Full length Lymphoid Enhancer Factor-1 (LEF-1) is a transcription factor that promotes cell growth via its interaction with the WNT signaling mediator beta-catenin. Truncated LEF-1 lacks ..

Purification of Laminin 5

Background: Lamin-5, a protein produced by skin, mammary and other epithelial cells, may be involved in the progression of cancer. Purified human laminin-5 is not commercially available, and we have ..

Microfluidic Production of Monodispersed Submicron EmulsionsThrough Filtration and Sorting of Satellite Drops

Background: In the past decade, droplets have been intensively used by the industries as an agent for drug preparations, for plastic polymerizations, and chemical processing. Recent advancements in m..

New Therapy to Inhibit Plasma Cells in Autoimmune Diseases

Background: In patients suffering from multiple sclerosis (MS) B cells, stimulated by axon antigens, infiltrate central nervous system. Technology: The inventors discovered a new class of antibodi..

Medical Spectroscopy

DOMAIN Aging of injuries on a victim’s body is an important aspect of forensic medicine. Currently, visual assessment and colorimetry based on empirical criteria are the most common techniques for t..

Diagnosis and prognosis of cancers in GI tract

DOMAIN Although the incidence of gastric carcinoma (tumour in stomach) is declining, this disease is still the second most frequent cause of cancer death worldwide. Gastric carcinomas are often not de..

Alginate - Drug Delivery System

DOMAIN The mucosal surfaces of the body (such as GI tract, respiratory tract, eye, and genitourinary tract) constitute the major target for drug and gene delivery. As such, mucous secretions can have ..

Rapid prediction of gene expression levels using spectroscopy

DOMAIN The study of gene expression in cells is increasingly being used to understand their biological function. The genes are up- and down-regulated by a complex protein regulatory network, which res..

A Microfabrication Process for Vertical Microelectrodes inside Polymer Microchannels

Background: For microfluidic applications, different electrodes inside the microfluidic channels may be patterned by metal evaporation methods such as thermal evaporation, electric beam evaporation, ..

Wall-Less Microfluidics with On-Site Magnetohydrodynamic (MHD) Pumps for Continuous Flow Control

Background: A disadvantage of closed microfluidic channels are that they are made from different materials. Also, most of the microchannels are fabricated from lithography techniques which require th..

Optimal selection of flurophores for bioimaging using hyperspectral cameras

DOMAIN In many situations it would be beneficial to have an instrument that can show In biology and medicine, fluorescent labelling is used to detect the location and concentration of various molecule..

Real time hyperspectral imaging

In many situations it would be beneficial to have an instrument that can show directly the spatial distribution of various chemical components in real time of a surface. Typical application areas are ..

Fiber optic bundle based optical coherence tomography

Background: Optical coherence tomography (OCT) has been used for high resolution optical imaging in many areas of medicine, especially ophthalmology. "Conventional wisdom" was that OCT could not be d..

ThirdEye – early detection of cerebral palsy (CP)

DOMAIN An early and accurate detection of cerebral palsy (CP) enables correct treatment at an early age to the infant at risk. Today’s methods for detecting CP are unable to establish a diagnosis un..

Methods and Compostions for the Treatment of Immune Disorders and Regulation of Cytokine and Growth Factor Signaling

Categories: Pharmaceuticals: Central Nervous System Disorders, Immune and Inflammatory Disorders Biotechnology: Assays, Diagnostics, Model Systems Background: Mgat5 is an enzyme that glycosylat..

MEMRI (manganese enhanced MRI)

DOMAIN Within an ageing population, ischemic heart disease (IHD) and secondary heart failure represent major challenges underlining a demand for diagnostic imaging to identify IHD in its different sta..

Phage-displayed Peptide Library with Affinity for Bacterial Elongation Factor Tu

Background: The highly abundant GTP binding protein elongation factor Tu (EF-Tu) fulfills multiple roles in bacterial protein biosynthesis. EF-Tu also binds other ligands, including four structurally..

High Density Micromachined Electrode Arrays Usable for Auditory Nerve Implants and Related Methods

Background: Auditory prostheses using microelectrode arrays suffer from a number of limitations. Issues that were not resolved are electrode size, the need for electrical wires to communicate with an..

Determining leakage through a heart valve

Determining the severity of a leakage through a heart valve is important. There are several parameters that are clinically interesting in this regard: the area of the lesion, the flow or flow rate thr..

Glycosylase enzymes

DOMAIN Glycosylases have found use in a number of methods aimed at analyzing DNA for the presence of altered nucleobases that could result from ionizing radiation or chemical oxidants, identifying mis..

Method and Apparatus of Using 3D Conductive Structures in Dielectrophoretic Separation Applications

Background: Researchers estimate that 80% of all machine failures are due to wear and that 1.3~1.6% of the GNP is lost to degradation of machinery due to friction-related wear. The abnormal abrasive ..

Rapid Bio-Molecules Detection by Adjacent Impedance Probing (AIP) Techniques

Background: Today, most detection schemes for DNA, proteins and other large biomolecules involve luminescent measurements using a variety of labels (i.e. fluorescent and/or chemiluminescent probes, p..

Fabrication of Suspended Carbon Micro and Nano-scale Structures

Recent attention has focused on high aspect ratio carbon micro-electromechanical (C-MEMS) because of the many applications possible, such as micro-electrodes in electromechanical sensors and miniaturi..

Method to Characterize Exhaled Nitric Oxide from the Airways Using a Sequence of Breathhold Maneuvers

Background: Exhaled nitric oxide (NO) arises from both airway and alveolar regions of the lungs, which provides an opportunity to characterize region-specific inflammation. Current methodologies rely..

Total Ankle Arthroplasty

Background: Total ankle arthroplasty (TAA) is the process of replacing a diseased ankle with a prosthetic ankle. Over the years there have been several efforts to provide a total ankle replacement sol..

Methods for Assessing the Temperature of Deep Tissue in vivo Using Non-ionizing Radiation

Background: Measuring temperature in tissue is highly relevant to treatments applied to tissue in which the tissue becomes heated. This includes methods that treat tissue with RF (Radio Frequency) su..

Microscope Immersion Fluid Applicator

Background: Microscopy is an important tool used by all researchers in the scientific community. Often, a microscope user will first scan the specimen with a low power dry objective and then wish to ..

A New Tandem-Affinity Tag for Two-Step Protein Purification under Fully Denaturing Conditions

Background: Preservation of posttranslational modifications during purification is crucial for successful mass spectrometric analyses of protein modifications. Current tandem-affinity purification st..

TRANSGENIC MOUSE MODEL FOR SCREENING ANALGESIC AGENTS

Background: UC Case No.: 2004-692 Patent Application Publication No.: WO/2006/017293 International Application No.: PCT/US2005/024697 This invention is an animal model and various cell-based mode..

New Polymeric Biomaterials

Technology: The invention is on new polymeric biomaterials. The new biomaterials were created by chemical synthesis with carbohydrates and amino acids as building blocks. The biopolymers have a speci..

Cell Encapsulation on a Microfluidic Platform

Background: Cell encapsulation is a highly useful tool in cell culturing, assay, and cell-based therapy applications. Encapsulation has traditionally been accomplished by extrusion through a nozzle, ..

A Diffusive Probe for Quantification of Optical Properties of Superficial Layers

Background: Diffuse optical spectroscopy (DOS) has been successfully employed for quantitative determination of in vivo optical properties and chromophore concentrations of deep tissues such as breas..

Use of Laser-Induced Fluorescence for Determination of Root Canal Pathology and Localization of Pathological Tissues to Facilitate Endodontic Therapy

Background: Currently endodontic therapy is based upon radiographic information and tactile feedback. Direct detection and localization of infected dentin and pupal tissue has not been possible. It h..

Nrf1 Deficient Mice as a Model for Liver Cancer and Non-Alcoholic Steatohepatitis

Background: Antioxidant and xenobiotic metabolizing enzymes are critical in the protection against chemically induced oxidative/electrophilic stress in cells that cause damage, DNA mutation, apoptosi..

Invention of New Dendritic Amphiphiles

Background: Amphiphilic compounds are of general interest in numerous disciplines in life sciences, especially in pharmacology and general chemistry, and numerous amphiphilic compounds are known in t..

Regulated Growth Factor Delivery for Nerve Regeneration

Background: Options for successful repair of peripheral nerves after traumatic injury remain suboptimal. Current strategies are limited to transfer of donor nerves from functional areas, with substan..

Automatic Detection and Diagnostics of Diabetic Retinopathy

Background: Diabetes is a condition that affects blood vessels throughout the body, particularly in the kidneys and eyes. Diabetic retinopathy is a complication of diabetes and is the leading cause o..

A Microfluidic Dynamic Vapor Control System

Background: Controlling the chemistry of small drops is troublesome owing to the difficulty in handling and metering small volumes. To change the chemistry of a 50nl drop by 10% would require adding ..

Polymeric Valves for Controlled Drug Delivery

Background: Biochips can be used in vitro or in vivo to deliver small, controlled amounts of chemicals or other molecules at controlled times and rates. Current delivery release mechanisms include el..

Methods for Treating Port Wine Stain Birth Marks, Hemangiomas and Other Conditions Caused By Aberrant Blood Vessels

Background: Cutaneous vascular lesions including port wine stains (PWS) and hemangiomas are frequently treated with laser and light devices. The pulsed dye laser (PDL) is the current standard means o..

Neuropeptide S (NPS) as a Treatment for Anxiety, Sleep Disorders, Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder, and Asthma

Background: Patent "WO02/31145" discloses a newly deorphanized GPCR system, Neuropeptide S (NPS), the endogenous ligand, and its cognate GPCR. However this patent does not detail the pharmacological ..

Method for Quantitative Digital Color Imaging of Objects

Background: In many disciplines, quantitative measurements of color are required to evaluate nondestructively the state of an object (e.g., quality of produce). This characterization is typically per..

High-Isolation Tunable MEMS Capacitive Switch

Background: For a typical MEMS switch, the resonant frequency is around 20 to 30 GHz which can not be employed by commercial wireless systems operating at a frequency band of 2 to 8 GHz. This resonan..

Reagents and Methods for Diagnosis of Attention Deficit Hyperactivity Disorder

Background: Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent disorder of early childhood. It affects an estimated 3-6% of elementary school children. ADHD consists of development..

Microfluidic Devices for Controlled Viscous Shearing and Formation of Amphiphilic Vesicles

Background: Amphiphilic vesicles are artificial cells with applications in drug delivery (including biomolecular nanomedicine such as DNA, peptides, proteins), combinatorial chemistry, nanoscale chem..

An Antibody-based Method for Reducing Ocular Inflammation Which Can Aid in Corneal Transplantation

HSV keratinitis is characterized, in part, by scarring of the eye as a result of HSV reactivation. To date, corneal transplantation is the standard treatment method. A significant obstacle preventing ..

A New Burr Design

Background: One of the great limitations in spine surgery is the difficulty with removing bone without damaging adjacent soft structures (such as the spinal cord, nerves, and durra). This difficulty ..

New Clinical Bymixer for Fast-Response, Adjustable Measurement of Mixed Expired Gas Fractions in the Anesthesia Circle Circuit

Background: The volume of O2 consumption (VO2) and the volume of CO2 production (VCO2) can give vital information about a patient under anesthesia. For example, monitoring VO2 can detect non-steady s..

Novel, Stand-alone, Closed Ventilating Circle Circuit with CO2 Absorption and Sensitive Spirometry Measures Pulmonary O2 Uptake During Anesthesia

High-Resolution X-Ray Crystal Structures of Tritrichomonas Foetus Inosine Monophosphate Dehydrogenase as Lead Compound for Structure-Based Drug Design

Background: Trichomoniasis is a venereal disease of cattle caused by a protozoan parasite, Tritrichomonas foetus. The disease has been reported worldwide with an estimated economic loss to the U.S. b..

A Polymeric Micro-Cantilever Resonator Array and Its Implications in Auditory Prostheses

Background: Ten percent of the general population suffers from hearing loss and that number rises to thirty five percent for people over sixty-five years of age. However, current digital hearing aids..

Selective Inhibition of Enzyme Isoforms of Nitric Oxide Synthetase

University of California, Irvine researchers have discovered a method to design and use selective inhibitors against a family of nitric oxide synthetase isoforms that control the production of nitric ..

Methods for Assessing the Condition of Bone In-Vivo Using Non-Ionizing Radiation

Background: The ability to assess the health and condition of bone tissue is important since bone tissue viability is closely linked to composition, structure, and physiology. Traditional methods for..

Vascularized Artificial Tissue

Background: There exists a need for thick artificial tissues to cover large tissue defects following trauma or surgical resection of tumor. The primary limitation in the design of these tissues as we..

hKCa3/KCNN3 Calcium Activated Potassium Channel: A Diagnostic Marker and Therapeutic Target for Heritable, Neurological and Psychiatric Diseases

University of California, Irvine researchers have discovered SKCa3-1b and SKCa3-1c, two novel isoform variants of the SK3 (also known as KCNN3) gene. The SK3 gene is located on human chromosome 1q21 i..

Novel Cytodiagnostic Markers For Cancer

Background: Cervical cancer is one of the leading causes of cancer-related death in women worldwide. Approximately 500,000 new cases are diagnosed each year and pre-cancerous abnormalities of the cer..

Wnt, Fz, and BMP-6 Receptors for the Treatment and Detection of Colon Cancer

Background: Ectopic activation of the Wnt signaling pathway leads to increased cellular growth and division in experimental organisms and mutations in the Wnt pathway. Wnt pathway genes are tightly l..

Platelet Aggregation Inhibitors

Thrombin is an enzyme in the blood that plays a key role in platelet formation during injury. While blood coagulation is essential for a surface wound, platelet activation underlies various pathologic..

ADP Glucose Receptor as a Target for Disorders Involving Platelet Aggregation

Background: Recently, activation of the P2Y12 G-protein coupled receptor (GPCRs) has been shown to be central to platelet aggregation. Drugs preventing platelet aggregation are being tested, but one ..

A New Process Of Adding Alkyl Groups To Organic Substrates Using TmI2(MeOCH2CH2OMe)3

Background: In the pharmaceutical industry, synthetic chemists often alkylate starting compounds to generate compounds that have more desirable properties. However, the current reagents used in this ..

Use Of Infectious And Pathogenic Clone Of A Lung Cancer-Inducing Retrovirus For Generation Of Therapeutic Reagents And Diagnostic Tests

Background: Jaagsiekte sheep retrovirus (JSRV) causes broncheolo-alveolar carcinoma in sheep and is a significant veterinary problem world-wide. Clinically and histopathologically, this disease has s..